1,722,118 research outputs found
Best available techniques (BATs) for oil spill response in the Mediterranean Sea: calm sea and presence of economic activities
No full textAn oil spill is the accidental or intentional discharge of petroleum products into the environment due to human activities. Although oil spills are actually just a little percent of the total world oil pollution problem, they represent the most visible form of it. The impact on the ecosystems can be severe as well as the impact on economic activities. Oil spill cleanup is a very difficult and expensive activity, and many techniques are available for it. In previous works, a methodology based on different kinds of criteria in order to come to the most satisfactory technique was proposed and the relative importance of each impact criterion on the basis of the Saaty’s Analytic Hierarchy Process (AHP) was also evaluated. After a review of the best available techniques (BATs) available for oil spill response, this work suggests criteria for BATs’ selection when oil spills occur in the Mediterranean Sea under well-defined circumstances: calm sea and presence of economic activities in the affected area. A group of experts with different specializations evaluated the alternative BATs by means of AHP method taking into account their respective advantages and disadvantages. © 2015, Springer-Verlag Berlin Heidelberg
Lipoprotein(a): from ancestral benefit to modern pathogen?
No full textWe review current concepts regarding the genetic, structural and metabolic features of lipoprotein(a), a major inherited cardiovascular pathogen. Although lipoprotein(a) is almost completely confined to a subset of primates, the hedgehog produces a lipoprotein(a)-like complex, which appears to have evolved independently from that of humans. The physiological role of lipoprotein(a) in humans is still unclear, and individuals with low or null concentrations of plasma lipoprotein(a) manifest no deficiency syndrome or disease. The integration of recent discoveries about the structure and metabolism of this unique lipoprotein particle has allowed the formulation of some hypotheses concerning the evolutionary advantages of synthesizing lipoprotein(a)-like particles
Migliori tecniche disponibili (BAT) per la prevenzione, il contenimento e la rimozione dei versamenti di prodotti petroliferi in mare
No full textBiochemical risk factors and patient's outcome: the case of lipoprotein(a)
No full textLipoprotein(a) (Lp(a)) is a genetic variant of low density lipoproteins and consists of the covalent association of the unique and enigmatic apolipoprotein(a) to apoliprotein B100. Despite the high degree of homology with low density lipoproteins, Lp(a) displays distinctive physicochemical properties, function and metabolism. The present article reviews the main biological and clinical evidences about the association between raised concentration of Lp(a) and athero-thrombotic diseases and provides tentative guidelines to improve the clinical usefulness of Lp(a) measurements
Doping e sport
No full textDoping is widely known as the use of banned substances and practices by athletes in an attempt to improve sporting performances. The term doping likely derives from 'dope', an ancient expression referred to a primitive alcoholic drink that was used as a stimulant in South African ceremonial dances; gradually, the term was extended and finally adopted his current significance. There are at least two essential reasons to support the fight against doping: the potential harmful effects on athletes and the depth corruption of the fair competition. An exhaustive list of banned substances and methods has been drawn by the International Olympic Committee and further accepted by other international Sport Authorities and Federations. This list, regularly updated, is basically divided into doping substances (stimulants, narcotic analgesics, anabolic agents, diuretics, peptide and glycoprotein hormones and analogues), doping methods (blood doping, pharmacological, chemical and physical manipulatio..
Lipoprotein(a): an emerging cardiovascular risk factor.
No full textLipoprotein(a) is a cholesterol-enriched lipoprotein, consisting of a covalent linkage joining the unique and highly polymorphic apolipoprotein(a) to apolipoprotein B100, the main protein moiety of low-density lipoproteins. Although the concentration of lipoprotein(a) in humans is mostly genetically determined, acquired disorders might influence synthesis and catabolism of the particle. Raised concentration of lipoprotein(a) has been acknowledged as a leading inherited risk factor for both premature and advanced atherosclerosis at different vascular sites. The strong structural homologies with plasminogen and low-density lipoproteins suggest that lipoprotein(a) might represent the ideal bridge between the fields of atherosclerosis and thrombosis in the pathogenesis of vascular occlusive disorders. Unfortunately, the exact mechanisms by which lipoprotein(a) promotes, accelerates, and complicates atherosclerosis are only partially understood. In some clinical settings, such as in patients at exceptionally low risk for cardiovascular disease, the potential regenerative and antineoplastic properties of lipoprotein(a) might paradoxically counterbalance its athero-thrombogenicity, as attested by the compatibility between raised plasma lipoprotein(a) levels and longevity
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