7,199 research outputs found
Franco Bassi
No full textScheda sul progettista grafico Franco Bassi, di cui presso il Centro di Documentazione sul Progetto Grafico di Aiap (Associazione italiana design della comunicazione visiva) è conservato un piccolo fondo
Franco Bassi
No full textAggiornamento della scheda sul progettista grafico Franco Bassi, di cui presso il Centro di Documentazione sul Progetto Grafico di Aiap (Associazione italiana design della comunicazione visiva) è conservato un fondo archivistico
La struttura della "Guida"
No full textDescrizione della struttura della Guida agli interventi di recupero dell'edilizia diffusa nel parco nazionale delle Cinque Terre, scritto insieme a Stefano F. Muss
Recensione di "Leopardi: guida allo Zibaldone" (Roma, Carocci, 2016) di Franco D'Intino - Luca Maccioni
No full textRecensione del vol. di Franco D'Intino-Luca Maccioni, "Leopardi: guida allo Zibaldone", Roma, Carocci, 201
Made in Italy NYC
No full textMade in Italy NYC was an exclusive free exhibition with a related catalogue, celebrating the rich heritage of postwar Italian graphic design and its enduring relationship with the U.S.
Both the exhibition and the book feature original pieces by significant and influential Italian, Italian American, and American designers. All the materials are from the archives of AIAP, the Italian Association of Visual Communication Design.
The exhibition and book were supported by Fedrigoni & Monotype and organized by Bryan Edmondson, founder of SEA X Pentagram. Francesco E. Guida, the archives coordinator, has curated the selection with Lorenzo Grazzani and edited the book's contents. Featured work includes pieces by John Alcorn, Walter Ballmer, Giulio Cittato, Silvio Coppola, Mario Dagrada, George Giusti, Milton Glaser, Franco Grignani, Max Huber, Anita Klinz, Balilla Magistri, Armando Milani, Claudia Morgagni, Bruno Munari, Ferenc Pinter, Giovanni Pintori, Paul Rand, Sergio Ruffolo, Massimo Vignelli and Heinz Waibl.
One Art Space, 23 Warren St., New York
21-23 May 202
Leopardi: guida allo Zibaldone
No full textL'unica ricognizione critica integrale dello Zibaldone: genesi, struttura, lingua e stile, fonti, temiThe most authoritative monograph on Leopardi's Zibaldone: genesis, structure, language and style, sources, themes
Proceedings of the International Symposium on Scale Modeling (Napoli, 02-04 marzo 2022)
No full textThis volume contains the works presented at the ninth edition of the symposium on scale models, ISSM9. The symposium brought together 53 scientists from 8 different countries and 3 continents, from both Academia and Research Centers; they participated virtually or in person to present the latest developments and trends in scale application and progress in several engineering fields (mostly in continuum mechanics and fluid dynamics). During the symposium there were 4 keynote talks, its related abstracts are here enclosed too. The contents of the talks are about the state-of-the-art of similitude theory and scale modeling and they are useful for any researcher interested in similar topics
Ligand induced internalization of CD38 results in intracellular Ca2+ mobilization. role of NAD+ transport across cell membranes
No full textCD38, a transmembrane glycoprotein
widely expressed in vertebrate cells, is a bifunctional
ectoenzyme catalyzing the synthesis and hydrolysis of
cyclic ADP-ribose (cADPR). cADPR is a universal
second messenger that releases calcium from intracellular
stores. Since cADPR is generated by CD38 at
the outer surface of many cells, where it acts intracellularly,
increasing attention is paid to addressing
this topological paradox. Recently, we demonstrated
that CD38 is a catalytically active, unidirectional
transmembrane transporter of cADPR, which then
reaches its receptor-operated intracellular calcium
stores. Moreover, CD38 was reported to undergo a
selective and extensive internalization through non
clathrin-coated endocytotic vesicles upon incubating
CD381 cells with either NAD1 or thiol compounds:
these endocytotic vesicles can convert cytosolic NAD
into cADPR despite an asymmetric unfavorable orientation
that makes the active site of CD38 intravesicular.
Here we demonstrate that the cADPR-generating
activity of the endocytotic vesicles results in
remarkable and sustained increases of intracellular
free calcium concentration in different cells exposed
to either NAD1, or GSH, or N-acetylcysteine. This
effect of CD38-internalizing ligands on intracellular
calcium levels was found to involve a two-step mechanism:
1) influx of cytosolic NAD1 into the endocytotic
vesicles, mediated by a hitherto unrecognized
dinucleotide transport system that is saturable, bidirectional,
inhibitable by 8-N3-NAD1, and characterized
by poor dinucleotide specificity, low affinity,
and high efficiency; 2) intravesicular CD38-catalyzed
conversion of NAD1 to cADPR, followed by outpumping
of the cyclic nucleotide into the cytosol and
subsequent release of calcium from thapsigarginsensitive
stores. This unknown intracellular trafficking
of NAD1 and cADPR based on two distinctive
and specific transmembrane carriers for either nucleotide
can affect the intracellular calcium homeostasis
in CD381 cells.—Zocchi, E., Usai, C.,
Guida, L., Franco, L., Bruzzone, S., Passalacqua, M.,
De Flora, A. Ligand-induced internalization of CD38
results in intracellular Ca21 mobilization: role of
NAD1 transport across cell membranes. FASEB J. 13,
273–283 (1999
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