85 research outputs found
L'assordante silenzio nero e le ostentate rivendicazioni rosse: gli antitetici modelli comunicativi dei due terrorismi italiani
No full textThe author introduces a comparative examination among the antithetical communicative expressions of the two terrorist experiences, appeared in the second Italian postwar period: the "black carnages" and the "red paramilitary attacks". Starting from their inverse correlation among the "meaning" and the "meant" of the terrorist "sign", the author reconstruct the opposite languages communicated by these different typologies of attempts
Tampa Natives Show: Guest, Paul Guzzo, Author & \u3ci\u3eTribune\u3c/i\u3e History Writer, January 9, 2014
No full textYou\u27ll enjoy this great show with special guest, Paul Guzzo. Paul is an Author and history writer for the Tampa Tribune. Watch as Paul shares how he became involved in his search of Tampa\u27s past! He recently wrote and article about the Tampa Natives Show, which was published on January 1st, 2014
L’amministrazione dei beni degli enti ecclesiastici, tra diritto canonico e diritto dello Stato
No full textIn this article the author examines the normative discipline of the Ecclesiastical Bodies’ administration, between Canon law and Italian law. The subject is included in the perspective of Pope Francis’ reform, also as a deontological issue
Scelte tragiche. Criteri per il “Triage” dei pazienti Covid-19 che hanno bisogno di terapia intensiva
No full textIn the present paper, the Author stresses the point that far from being a state of emergency where law and legal principles are suspended, Triage is a legal question to be faced with formal criteria. Every form of consequentialist thinking adopting different kind of material criteria, such those embraced in the guidelines drawn up by national medical societies in order to manage the pandemic, by necessarily involving a discrimination against fragile patients is incompatible with the basic principle of fundamental equality of human lives. The Author particularly focuses on the German case, where for its special constitutional tradition this basic principle is strongly avowed
Prevalence of Fatigue in Head and Neck Cancer Survivors
No full textIntroduction: In head and neck cancer (HNC) patients, fatigue is present throughout the course of treatment and during follow-up. There are limited data about the prevalence and factors associated with fatigue in HNC survivors. The objectives of this study were to assess the prevalence of fatigue and its interference with daily life activities and examine the association between fatigue and gender, age, primary tumour site, Human Papillomavirus (HPV) status, previous oncologic therapy, and time since end of treatment. Methods: Consecutive locally advanced HNC patients having completed curative treatment at least 1 year earlier and free of disease were asked to fill in the Brief Fatigue Inventory (BFI) questionnaire. Fatigue was categorized according to BFI average score as absent (0), mild (>0 to 6 to ≤10). Results: From February 2015 to July 2016, 129 patients (median age = 60 years old; 67% male) were evaluated. Primary sites of cancer were oropharynx (46%, with 4/5 patients HPV positive), nasopharynx (22%), larynx/hypopharynx (14%), oral cavity (13%), and paranasal sinus or salivary gland (5%). Oncologic treatment was completed 12 to 96 months earlier (median = 34 months). Fatigue was reported as absent in 15% of the patients, mild in 67%, moderate in 11%, and severe in 7%. No association between BFI average score and the analyzed variables was identified. Discussion: Moderate and severe fatigue was reported in 18% of HNC survivors. Further research is needed to assess its causes and improve the management
Final Cut
No full textInfluenced by daily life, “Final Cut” captures an outlook on the modern city. Themes include bodily function, entertainment, and consumption. I had also been watching a lot of horror movies, namely, “Return of the Living Dead” (1985.) At the time they definitely played into my thought process too. Being alone in the city can have a creepy quality. You find yourself in public spaces oftentimes crowded places with strangers. We all watch these people and have the sense that some of them are watching us, so there’s a kind of spotlight on the individual
Ethylene-auxin crosstalk regulates postharvest fruit ripening process in apple
No full textThe ripening of climacteric fruits, such as apple, is represented by a series of genetically programmed events orchestrated by the action of several hormones. In this study, we investigated the existence of a hormonal crosstalk between ethylene and auxin during the post-harvest ripening of three internationally known apple cultivars: 'Golden Delicious', 'Granny Smith' and 'Fuji'. The normal climacteric ripening was impaired by the exogenous application of 1-methylcyclopropene (1-MCP) that affected the production of ethylene and the physiological behaviour of specific ethylene-related quality traits, such as fruit texture and the production of volatile organic compounds. The application of 1-MCP induced, moreover, a de-novo accumulation of auxin. The RNA-Seq wide-transcriptome analysis evidenced as the competition at the level of the ethylene receptors induced a cultivar-dependent transcriptional re-programming. The DEGs annotation carried out through the KEGG database identified as most genes were assigned to the plant hormone signaling transduction category, and specifically related to auxin and ethylene. The interplay between these two hormones was further assessed through a candidate gene analysis that highlighted a specific activation of GH3 and ILL genes, encoding key steps in the process of the auxin homeostasis mechanism. Our results showed that a compromised ethylene metabolism at the onset of the climacteric ripening in apple can stimulate, in a cultivar-dependent fashion, an initial de-novo synthesis and de-conjugation of auxin as a tentative to restore a normal ripening progression
TRPP2 dysfunction decreases ATP-evoked calcium, induces cell aggregation and stimulates proliferation in T lymphocytes
No full textBackground: Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage renal disease (ESRD) in adult patients. Other clinical manifestations of this pathology include hypertension, haematuria, abdominal pain, cardiovascular system alterations and intracranial aneurysms. ADPKD is linked to mutations in either PKD1 or PKD2 that codifies polycystin-1 (PC1) and polycystin-2 (PC2 or TRPP2), respectively. PC1 and TRPP2 are membrane proteins that function as receptor-channel elements able to regulate calcium homeostasis. The function of polycystins has been mainly studied in kidney cells; but the role of these proteins in T lymphocytes is not well defined. Methods: T lymphocytes were produced from ADPKD1 and ADPKD2 patients as well as from non-ADPKD subjects undergoing renal replacement therapy (RRT) and healthy controls. Protein expression and phosphorylation levels were analysed by western blotting, cell proliferation was calculated by direct counting using trypan blue assay and intracellular calcium concentration was measured by Fura-2 method. Results: PKD2 mutations lead to the significant reduction of TRPP2 expression in T lymphocytes derived from ADPKD patients. Furthermore, a smaller TRPP2 truncated protein in T lymphocytes of patients carrying the mutation R872X in PKD2 was also observed, suggesting that TRPP2 mutated proteins may be stably expressed. The silencing or mutation of PKD2 causes a strong reduction of ATP-evoked calcium in Jurkat cells and ADPKD2 T lymphocytes, respectively. Moreover, T lymphocytes derived from both ADPKD1 and ADPKD2 patients show increased cell proliferation, basal chemotaxis and cell aggregation compared with T lymphocytes from non-ADPKD subjects. Similarly to observations made in kidney cells, mutations in PKD1 and PKD2 dysregulate ERK, mTOR, NFkB and MIF pathways in T lymphocytes. Conclusions: Because the alteration of ERK, mTOR, NFkB and MIF signalling found in T lymphocytes of ADPKD patients may contribute to the development of interstitial inflammation promoting cyst growth and kidney failure (ESRD), the targeting of inflammasome proteins could be an intriguing option to delay the progression of ADPKD. © 2019 The Author(s)
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