7,369 research outputs found
Data for: Improved modelling and critical analysis of future electrification pathways: the case of Tanzania
No full textSupplementary material accompanying the paper:Improved modelling and critical analysis of future electrification pathways: the case of TanzaniaMatteo V. Rocco, Elena Fumagalli, Chiara Vigone, Ambrogio Miserocchi, Emanuela ColomboDepartment of Energy, Politecnico di MilanoCopernicus Institute of Sustainable Development, Utrecht UniversityCorresponding author: Via Lambruschini 4, 21056 Milan, Italy. E-mail: [email protected]
William Barnes' s Poems in standard English, translated from the Italian
No full textIl terzo volume delle opere di William Barnes raccoglie le sue traduzioni letterarie da lingue europee e orientali. La parte italiana a cura di E. Di Rocco e E. Spandri comprende testi di Petrarca e Metastasio che vengono commentati in nota e introdotti da una prefazione
Premalignant and pre-invasive lesions of the breast
No full textPremalignant and pre-invasive lesions of the breast belong to a complex and heterogeneous group of lesions and represent a matter of remarkable interest from both clinical and biological standpoints. These frequent noninvasive alterations are related with an increased probability of breast cancer development. What is more, these breast abnormalities show extremely variable risks of progression toward invasive forms of disease. Indeed, while there are many histologically defined premalignant lesions in the breast, only a subset of them constitute true neoplastic precursors that will progress to invasive cancer. Disappointingly, it is currently not conceivable to identify a priori, with absolute certainty, which of these precursors will progress and which not. Therefore, classifying risk indicators, precursors, and non-obligate precursors of invasive breast cancer, and ultimately define robust protocols for their clinical management, is a hot topic in the multidisciplinary approach to breast cancer patients, that involves pathologists, radiologists, surgeons, and oncologists
Advances in Early Breast Cancer Risk Profiling: From Histopathology to Molecular Technologies
No full textEarly breast cancer (BC) is the definition applied to breast-confined tumors with or without
limited involvement of locoregional lymph nodes. While risk stratification is essential for guiding
clinical decisions, it can be a complex endeavor in these patients due to the absence of comprehensive
guidelines. Histopathological analysis and biomarker assessment play a pivotal role in defining
patient outcomes. Traditional histological criteria such as tumor size, lymph node involvement, histo-
logical type and grade, lymphovascular invasion, and immune cell infiltration are significant prog-
nostic indicators. In addition to the hormone receptor, HER2, and—in specific scenarios—BRCA1/2
testing, molecular subtyping through gene expression profiling provides valuable insights to tailor
clinical decision-making. The emergence of “omics” technologies, applicable to both tissue and liquid
biopsy samples, has broadened our arsenal for evaluating the risk of early BC. However, a pressing
need remains for standardized methodologies and integrated pathological models that encompass
multiple analytical dimensions. In this study, we provide a detailed examination of the existing
strategies for early BC risk stratification, intending to serve as a practical guide for histopathologists
and molecular pathologists
Trust breaks down in electronic contexts but can be repaired by some initial face-to-face contact
No full textLos Angele
Encuentros con Elena Poniatowska
No full textThe author analyzes testimonial literature from the perspective of female literature through his meeting with Elena Poniatowska. An analysis of reality vs. Fiction in Elena, Jesusa and Tinisima.El autor analiza, desde su encuentro con Elena Poniatowska, la vertiente de la literatura testimonial como literatura de mujeres. Un análisis interior de la relación entre realidad y ficción, entre Elena, Jesusa o Tinísima
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