1,721,628 research outputs found
Recensione di Landero, Luis, Lluvia fina. Barcelona: Tusquets, (2019). pp. 272
No full textCitation Guarino, A. (2020). Review of Lluvia fina, by Landero, L. Rassegna iberistica, 43(113), 185-188
Riapertura della classe “Letteratura latino-americana” della BIBLIOTECA DELL’IILA Discorso del professore Augusto Guarino
Full text linkL’Annuario raccoglie una selezione delle principali attività istituzionali dell’IILA, sia in Italia
che negli altri paesi membri. Abbiamo deciso di non segnalare pedissequamente tutte le attività
realizzate, che comunque -tutte- appaiono nella nostra newsletter mensile, consultabile nel nuovo
sito internet www.iila.org, ma soltanto quelle più significative istituzionalmente
YB-1 protein is secreted as consequence of oxidative stress and induces G2/M phase block in receiving cells
No full textCell signalling is the complex network of connections between cells and inside the single cell. Protein trafficking is deeply involved in cell signalling. Different proteins are ordered in clusters of receptors of extracellular signals, transducers, sensors and biological response effectors. Together, they are arranged in molecular pathways that are required for the maintenance of cell homeostasis. Protein secretion is a relevant component of eukaryotic cell signalling. The prototype cold-shock Y-box binding protein 1 (YB- 1) is a multifunctional protein which regulates a variety of fundamental biological processes. Among them, cellular stress response and cell proliferation. Recently YB-1 has been found in human extracellular fluids and shown to be secreted by different cell types. My recent research activity was focused on YB-1 protein secretion to investigate on its role as a potential paracrine signal to elicit changes or responses in nearby cells, altering their behaviour. Low amounts of extracellular YB-1 are released by HEK293T cells in physiological condition. Interestingly, YB-1 secretion was enhanced following oxidative insults. In parallel, the assembly of YB-1 in stress granules (SGs), cytoplasmic foci where untranslated mRNAs are sorted or processed for re-initiation, degradation or packaging into mRNPs was verified.
Purified recombinant human YB-1 (rYB-1) and enriched frac- tions of YB-1 from HEK293T cell culture medium (CCM-YB-1) were produced. Both forms of YB-1 protein have anti-proliferative activity on different recipient cell lines, including HaCaT cells. In particular, inhibition of human keratinocytes proliferation by extracellular YB-1 was associated to a G2/M cell cycle arrest, induction of p21WAF and reduction of 'Np63D protein level. The obtained results suggest that sustained release of full length YB-1 protein, by stress stimuli acts as paracrine/autocrine signal stimulating
cell cycle arrest
El doble de todas las cosas. Estudios sobre Ramón Gómez de la Serna
No full textEssays about Ramón Gómez de la SernaEstudios sobre Ramón Gómez de la Sern
Elogio de una presencia incómoda. La obra de Ramón Gómez de la Serna entre interpretaciones y reverberaciones
No full textIl contributo fa il punto sullo stato attuale degli studio su Ramón Gómez de la Sern
Echi del “Lazarillo” in “Rinconete y Cortadillo” di Miguel de Cervantes
No full textIl contributo analizza l'influenza del Lazarillo de Tormes sulla novella Rinconete y Cortadillo di Miguel de Cervante
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