20,076 research outputs found
Republicopteron douseae Archibald & Gu & Mathewes 2022, new species
No full textRepublicopteron douseae new species (Figs. 5–7) Diagnosis. As for genus. Description. Holotype tegmen. As in diagnosis and the following. Darkly infuscate throughout wherever preserved (darkness differing among specimens presumably by preservation) with some light spots between veins, crossveins as in P. maculata, but not as many or as distinct (perhaps preservation?). ScP with eight accessory branches preserved, surely more in missing basal region; no stridulatory file detected on CuPb. Type specimens. Holotype. SR 00-04-06 part, no counterpart (Fig. 5), a well-preserved anterior basal-mid region of a tegmen, precostal region not preserved, with a fragmentary portion of a second wing closely associated and a beetle preserved between fragments; deposited in SR; collected by Cassie Douse at Republic locality B4131, May 1, 2000, labelled: Holotype, Republicopteron douseae Archibald, Gu, and Mathewes. Paratype 1: SRUI 09- 95 - 73, (Fig. 6), collected by Michael Santino at Republic exposure A0307, April 19, 2009; labelled Republicopteron douseae Archibald, Gu, and Mathewes Paratype 1. Paratype 2: SR 21-005-001, (Fig. 7), collected by Gregg Wilson at Republic exposure B4131, May 14, 2014; labelled Republicopteron douseae Archibald, Gu, and Mathewes Paratype 2. Locality and age. Republic, Washington, USA; Tom Thumb Tuff Member of the Klondike Mountain Formation exposures B4131, 51.18 0.09 Ma. old and A0307, 51.45 0.12 Ma. old, mid Ypresian. Etymology. The specific epithet is a patronym formed from the surname of Cassie Douse, collector and donor of the holotype.Published as part of Archibald, S. Bruce, Gu, Jun-Jie & Mathewes, Rolf W., 2022, The Palaeorehniidae (Orthoptera, Ensifera, " Zeuneropterinae "), and new taxa from the early Eocene Okanagan Highlands, western North America, pp. 559-572 in Zootaxa 5100 (4) on pages 568-569, DOI: 10.11646/zootaxa.5100.4.6, http://zenodo.org/record/622500
Republicopteron Archibald & Gu & Mathewes 2022, new genus
No full textRepublicopteron new genus (Figs. 5–7) Type and only species. Republicopteron douseae. Diagnosis. Tegmen of Republicopteron most easily separated from those of other Palaeorehniidae as in Table 1. Description. As in species description. Etymology. The genus name is a toponym referring to the town of Republic, Washington, and – opteron, from the Greek -pteron (πτερόν), meaning wing. Gender, neuter. Distribution and age. As for its only species, below.Published as part of Archibald, S. Bruce, Gu, Jun-Jie & Mathewes, Rolf W., 2022, The Palaeorehniidae (Orthoptera, Ensifera, " Zeuneropterinae "), and new taxa from the early Eocene Okanagan Highlands, western North America, pp. 559-572 in Zootaxa 5100 (4) on page 568, DOI: 10.11646/zootaxa.5100.4.6, http://zenodo.org/record/622500
Ypopteron Archibald & Gu & Mathewes 2022, new genus
No full textYpopteron new genus (Fig 4.) Diagnosis. Tegmen of Ypopteron most easily separated from those of other Palaeorehniidae as in Table 1. Type and only species. Y. nicola. Description. As for its only species, see below. Etymology. The genus name refers to the Ypresian age, and – opteron, from the Greek -pteron (πτερόν), meaning wing. Gender, neuter. Distribution and age. As for its only species, below.Published as part of Archibald, S. Bruce, Gu, Jun-Jie & Mathewes, Rolf W., 2022, The Palaeorehniidae (Orthoptera, Ensifera, " Zeuneropterinae "), and new taxa from the early Eocene Okanagan Highlands, western North America, pp. 559-572 in Zootaxa 5100 (4) on page 566, DOI: 10.11646/zootaxa.5100.4.6, http://zenodo.org/record/622500
Latedactylus Zheng & Cao & Gu 2023, gen. nov.
No full textGenus <i>Latedactylus</i> gen. nov. <p>urn:lsid:zoobank.org:act: 086A00E3-AAD7-4E3D-8374-E5CFFE61772B</p> <p> <b>Diagnosis.</b> The second segment of cercus cylindrical, longer and distinctly slender than the first; metatibia without swimming plates; metatarsus about three times as long as apical spurs of metatibia; dorsal margin of metatibia with sparse denticles.</p> <p> <b>Etymology.</b> The genus name is taken from the Latin ‘late’ and ‘dactylus’, ‘late’ means wide, ‘dactylus’ is a suffix commonly used in the genus names of tridactylids.</p> <p> <b>Type Species.</b> <i>Latedactylus longapedi</i> <b>sp. nov.</b></p>Published as part of <i>Zheng, Chengjie, Cao, Chengquan & Gu, Jun-Jie, 2023, A new genus and a new species of pygmy mole cricket from mid-Cretaceous amber in North Myanmar (Orthoptera: Caelifera: Tridactyloidea), pp. 296-300 in Zootaxa 5339 (3)</i> on page 297, DOI: 10.11646/zootaxa.5339.3.7, <a href="http://zenodo.org/record/8309090">http://zenodo.org/record/8309090</a>
Ypopteron nicola Archibald & Gu & Mathewes 2022, new species
No full textYpopteron nicola new species (Fig. 4) Haglidae, Prophalangopsinae sp.: Archibald and Mathewes 2000: 1443, Fig. 3. Diagnosis. As for genus. Description. Holotype tegmen. As in diagnosis and: about 6.5 cm long as preserved (small portion of basalmost region missing); membrane apparently infuscate throughout; RA, RP branch distal branching of MA, MP; RP branching eight times, one branch branched again near margin; MA, MP branch at level of CuA joining CuPaα, distally parallel with branches of RP; CuA+CuPaα with five branches preserved, probably total; no stridulatory file detected on CuPb; simple crossveins throughout proximal posterior portion; zigzag intercalated crossveins forming pentagons in apical portion of overlapping wing between branches of RP. Type specimen. Holotype. Q-1010, part (no counterpart), two or more wings, two almost perfectly overlapping. The anterior regions (RA, stem of RP, ScA, SCP and precostal region) are missing or covered by portions of one or more wing(s); labelled Ypopteron nicola Archibald, Gu, and Mathewes, holotype; collected by Jurgen Mathewes, 1989; deposited in the collections of Simon Fraser University. Locality and age. Quilchena, British Columbia; Coldwater Beds; mid Ypresian, 51.5 ± 0.4 Ma. old. Etymology. The specific epithet refers to the Nicola Valley, where the Quilchena locality is located.Published as part of Archibald, S. Bruce, Gu, Jun-Jie & Mathewes, Rolf W., 2022, The Palaeorehniidae (Orthoptera, Ensifera, " Zeuneropterinae "), and new taxa from the early Eocene Okanagan Highlands, western North America, pp. 559-572 in Zootaxa 5100 (4) on pages 566-567, DOI: 10.11646/zootaxa.5100.4.6, http://zenodo.org/record/622500
Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
Full text linkOverexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common chromosomal translocations. t(8;21) is one of the most common AML-associated translocation and results in the AML1-ETO fusion protein. Overexpression of AML1-ETO in NIH3T3 cells leads to increased phosphorylation of Ser63 in c-Jun, which is generally JNK dependent. The role of the JNK signaling pathway for the functional properties of AML1-ETO is, however, unknown.
In the present study we found high expression levels of c-jun mRNA in t(8;21), t(15;17) or inv(16) positive patient cells by microarray analysis. Within t(8;21) positive patient samples, there was a correlation between AML1-ETO and c-jun mRNA expression levels. In myeloid U937 cells, c-jun mRNA and c-Jun protein expression levels increased upon induction of AML1-ETO. AML1-ETO transactivated the human c-jun promoter through the proximal AP-1 site via activating the JNK signaling pathway. JNK targets c-Jun and ATF-2, which also bind to the proximal AP-1 site in U937 cells, were also phosphorylated upon AML1-ETO induction. Furthermore, AML1-ETO induction increased the DNA binding capacity of c-Jun and ATF-2 to the proximal AP-1 site of the c-jun promoter, which might result in their enhanced transactivation capacities.
Interference with JNK and c-Jun activation by using JIP-1 or a JNK inhibitor reduced the transactivation capacity of AML1-ETO on the c-jun promoter and the pro-apoptotic function of AML1-ETO in U937 cells. AML1-ETO seems to activate the JNK signaling pathway by inducing the expression of a cytoplasmic factor, possibly G-CSF, because supernatant of AML1-ETO expressing cells was sufficient to induce phosphorylation of JNK and c-Jun in wildtype U937 cells.
This data demonstrates a novel mechanism of how AML1-ETO might exert positive effects on target gene expression and identifies the proto-oncogene c-jun as a common target gene in AML patient cells.Überexpression des Proto-Onkogens c-jun und konstitutive Aktivierung des Jun NH2-terminalen Kinase (JNK)-Signaltransduktionsweges sind wichtig für die leukämische Transformation in der Chronischen Myeloischen Leukämie. Die Expression von c-jun bei Akuter Myeloischer Leukämie (AML) mit den häufigsten reziproken Translokationen ist jedoch unbekannt. Bei einer der häufigsten AML Translokation t(8;21) wurde in Fibroblastenzellen gezeigt, daß das AML1-ETO-Fusionsgen die Phosphorylierung des Serin 63 in c-Jun erhöht. Die Rolle des JNK-Signalweges, der c-Jun am Serin 63 phosphorylieren kann, für die Funktion von AML1-ETO wurde bisher jedoch nicht untersucht. Weiterhin kann aktiviertes c-Jun durch eine positive Rückkoppelungsschleife über den c-jun Promotor zur Erhöhung der c-Jun Expression führen.
In der vorliegenden Arbeit konnten wir zeigen, daß AML Patientenzellen mit den häufigen Translokationen: t(8;21), t(15;17) oder inv(16) mehr c-jun mRNA besitzen im Vergleich zu Knochenmarkszellen gesunder Probanden. Weiterhin fanden wir eine hohe Korrelation zwischen der AML1-ETO und der c-jun mRNA bei t(8;21) positiven Patientenzellen. Induktion von AML1-ETO in der myeloischen U937 Zellinie erhöhte sowohl c-jun mRNA als auch c-Jun Proteinexpression. Damit konnten wir zeigen, daß AML1-ETO die Erhöhung der c-jun Expression bewirkt. Wir untersuchten den molekularen Mechanismus in U937 Zellen mittels transienter Transfektionen und fanden, daß AML1-ETO den c-jun Promotor durch die proximale AP-1 Seite transaktiviert. Diese Transaktivierung erfolgte indirekt über Aktivierung des JNK-Signaltransduktionsweges durch AML1-ETO. AML1-ETO-Induktion führte auch zur Phosphorylierung der JNK-Zielproteine c-Jun und ATF-2. Diese konnten im Gelretardierungsassay an die proximale AP-1 Seite des c-jun Promotors binden und wurden durch AML1-ETO-Induktion in ihrer Bindungsfähigkeit verstärkt. Deshalb nehmen wir an, daß die Transaktivierungskapazität des c-jun Promotors durch AML1-ETO über die Aktivierung des JNK-Signalweges läuft
Two new species of Elcaninae (Orthoptera, Elcanidae) recorded from the Early Cretaceous China
No full textTian, He, Ren, Dong, Gu, Jun-Jie (2022): Two new species of Elcaninae (Orthoptera, Elcanidae) recorded from the Early Cretaceous China. Zootaxa 5128 (4): 589-596, DOI: https://doi.org/10.11646/zootaxa.5128.4.
sj-docx-1-ict-10.1177_15347354241237973 – Supplemental material for Clinical Efficacy and Gut Microbiota Regulating-Related Effect of Si-Jun-Zi Decoction in Postoperative Non-Small Cell Lung Cancer Patients: A Prospective Observational Study
No full textSupplemental material, sj-docx-1-ict-10.1177_15347354241237973 for Clinical Efficacy and Gut Microbiota Regulating-Related Effect of Si-Jun-Zi Decoction in Postoperative Non-Small Cell Lung Cancer Patients: A Prospective Observational Study by Yiyun He, Ao Qi, Yifeng Gu, Congmeng Zhang, Yichao Wang, Wenxiao Yang, Ling Bi, Yabin Gong, Lijing Jiao and Ling Xu in Integrative Cancer Therapies</p
FIGURE 1 in Two new species of Elcaninae (Orthoptera, Elcanidae) recorded from the Early Cretaceous China
No full textFIGURE 1. Location diagram of Huangbanjigou village, Beipiao City, Liaoning Province, ● represent locality of fossils.Published as part of Tian, He, Ren, Dong & Gu, Jun-Jie, 2022, Two new species of Elcaninae (Orthoptera, Elcanidae) recorded from the Early Cretaceous China, pp. 589-596 in Zootaxa 5128 (4) on page 590, DOI: 10.11646/zootaxa.5128.4.8, http://zenodo.org/record/648010
A exceptionally-preserved new species of Barchaboilus (Orthoptera: Prophalangopsidae) from the Middle Jurassic of Daohugou, China
No full textGu, Jun-Jie, Qiao, Ge-Xia, Ren, Dong (2011): A exceptionally-preserved new species of Barchaboilus (Orthoptera: Prophalangopsidae) from the Middle Jurassic of Daohugou, China. Zootaxa 2909: 64-68, DOI: 10.5281/zenodo.27779
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