126,529 research outputs found
Letter From H. Wayne Gruber to Alfred L. Shoemaker, Undated
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, circa 1950. Within, Gruber provides some Pennsylvania Dutch beliefs from Berks County, Pennsylvania and stories of farmer Christian Gruber\u27s ability to remove hexes from people.https://digitalcommons.ursinus.edu/shoemaker_documents/1103/thumbnail.jp
Letter From H. Wayne Gruber to Alfred L. Shoemaker, 1949
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, dated 1949. Within, Gruber writes on a variety of topics including a cure for horse colic, uses for leftover pie dough, and quarreling between town folk and country folk.https://digitalcommons.ursinus.edu/shoemaker_documents/1102/thumbnail.jp
Letter From H. Wayne Gruber to Alfred L. Shoemaker, March 14, 1950
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, dated March 14, 1950. Within, Gruber writes to provide material for Shoemaker\u27s radio program and discusses his school days and later education.https://digitalcommons.ursinus.edu/shoemaker_documents/1271/thumbnail.jp
Letter From H. Wayne Gruber to Alfred L. Shoemaker, January 11, 1949
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, dated January 11, 1949. Within, Gruber provides information on the variety of garden vegetables he remembers being grown in his mother\u27s garden.https://digitalcommons.ursinus.edu/shoemaker_documents/1164/thumbnail.jp
Letter From H. Wayne Gruber to Alfred L. Shoemaker, February 4, 1949
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, dated February 4, 1949. Within, Gruber inquires about a potential interest in some Pennsylvania Dutch verses he composed regarding his childhood.https://digitalcommons.ursinus.edu/shoemaker_documents/1067/thumbnail.jp
Letter From H. Wayne Gruber to Alfred L. Shoemaker, December 18, 1948
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, dated December 18, 1948. Within, Gruber lists various beliefs and superstitions that can be found within Berks County, Pennsylvania, ranging from signs of good luck to omens of death and misfortune. Gruber also inquires about a verse called Die Schnitzel Bunk and hopes that Shoemaker will be able to visit and view his diary and scrapbooks.https://digitalcommons.ursinus.edu/shoemaker_documents/1106/thumbnail.jp
Letter From H. Wayne Gruber to Alfred L. Shoemaker, March 2, 1948
No full textA typed letter from H. Wayne Gruber addressed to Alfred L. Shoemaker, dated March 2, 1948. Within, Gruber describes childhood rhymes in Pennsylvania German and the ball-games he used to play, as well as a Pow-wow story and other folklore.https://digitalcommons.ursinus.edu/shoemaker_documents/1137/thumbnail.jp
Costumes, moeurs coutumes des russes
No full textdargestellt in Gemählden mit Beschreibungen von Dr. J.G. Gruber und Ch.G.H. Geissler, Zeichner und Reisegesellschafter des Herrn Etatsraths von Pallas = Costumes, moeurs coutumes des russes / dessinés à Saint-Pétersbourg par Ch.G.H. Geissler, dessinateur, attaché à M. de Pallas, décrits par M. le Dr. J.G. Gruber, et traduits par M. de L******.Deutsch-französischer Paralleltex
Letter From H. Wayne Gruber to Alfred L. Shoemaker, March 27, 1948
No full textIn this typed letter to Alfred L. Shoemaker, H. Wayne Gruber clarifies a method of coloring Easter eggs by boiling and dissolving grab. He also explains a traditional Easter hunt he played as a child and lists some Aldeweiva glawe or Old women beliefs.https://digitalcommons.ursinus.edu/shoemaker_documents/1147/thumbnail.jp
The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.
No full textCiliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67(tm1Dgen/H1) knockout mouse that closely resemble those seen in Wnt5a and Ror2 knockout mice. These include pulmonary hypoplasia, ventricular septal defects, shortening of the body longitudinal axis, limb abnormalities, and cochlear hair cell stereociliary bundle orientation and basal body/kinocilium positioning defects. The basal body/kinocilium complex was often uncoupled from the hair bundle, suggesting aberrant basal body migration, although planar cell polarity and apical planar asymmetry in the organ of Corti were normal. TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone. Additionally, the extracellular N-terminal domain of TMEM67 preferentially binds to Wnt5a in an in vitro binding assay. Cultured lungs of Tmem67 mutant mice failed to respond to stimulation of epithelial branching morphogenesis by Wnt5a. Wnt5a also inhibited both the Shh and canonical Wnt/β-catenin signalling pathways in wild-type embryonic lung. Pulmonary hypoplasia phenotypes, including loss of correct epithelial branching morphogenesis and cell polarity, were rescued by stimulating the non-canonical Wnt pathway downstream of the Wnt5a-TMEM67-ROR2 axis by activating RhoA. We propose that TMEM67 is a receptor that has a main role in non-canonical Wnt signalling, mediated by Wnt5a and ROR2, and normally represses Shh signalling. Downstream therapeutic targeting of the Wnt5a-TMEM67-ROR2 axis might, therefore, reduce or prevent pulmonary hypoplasia in ciliopathies and other congenital conditions
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