141,093 research outputs found

    Beobachtungen über Temperatur- und Pulsverhältnisse bei Gebärenden

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    von Dr. A. G. Gruber, d. Z. Assistent des Vorstehers der Entbindungsanstalt in Bern"Von der h. medicinischen Fakultät der Berner Hochschule gekrönte Preisschrift."Dissertation Medizinische Fakultät der Universität Bern 186

    Graduate recital, choral conducting. Gruber, D. E., 1988

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    Recorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, April 15, 1988, 8:00 p.m., the 331st concert of the School of Music's 1987-1988 season.Mixed chorus, conducted by Deborah Eve Gruber ; Julianne Borg, soprano ; Heidi Hertel, alto ; Lyle Brown, tenor ; David Veenhuis, bass ; Matthew Elliott, piano (1st work ; Susan Dean, organ (2nd work).In partial fulfillment of the requirements of the Master of Music degree in choral conducting, Western Michigan University, 1988.Information from performance program.Missa Brevis in F major, K. 192 / Wolfgang Amadeus Mozart -- Solemn mass / Louis Vierne

    The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.

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    Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67(tm1Dgen/H1) knockout mouse that closely resemble those seen in Wnt5a and Ror2 knockout mice. These include pulmonary hypoplasia, ventricular septal defects, shortening of the body longitudinal axis, limb abnormalities, and cochlear hair cell stereociliary bundle orientation and basal body/kinocilium positioning defects. The basal body/kinocilium complex was often uncoupled from the hair bundle, suggesting aberrant basal body migration, although planar cell polarity and apical planar asymmetry in the organ of Corti were normal. TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone. Additionally, the extracellular N-terminal domain of TMEM67 preferentially binds to Wnt5a in an in vitro binding assay. Cultured lungs of Tmem67 mutant mice failed to respond to stimulation of epithelial branching morphogenesis by Wnt5a. Wnt5a also inhibited both the Shh and canonical Wnt/β-catenin signalling pathways in wild-type embryonic lung. Pulmonary hypoplasia phenotypes, including loss of correct epithelial branching morphogenesis and cell polarity, were rescued by stimulating the non-canonical Wnt pathway downstream of the Wnt5a-TMEM67-ROR2 axis by activating RhoA. We propose that TMEM67 is a receptor that has a main role in non-canonical Wnt signalling, mediated by Wnt5a and ROR2, and normally represses Shh signalling. Downstream therapeutic targeting of the Wnt5a-TMEM67-ROR2 axis might, therefore, reduce or prevent pulmonary hypoplasia in ciliopathies and other congenital conditions

    Das Zusammenleben von Römern und Christen: Minderheiten haben's schwer; Lernzirkel für den Geschichts- und Religionsunterricht der Klassen 5 bis 7

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    Das Zusammenleben von Römern und Christen : Minderheiten haben´s schwer ; Lernzirkel für d. Geschichts- u. Religionsunterricht d. Klassen 5 bis 7 / Bernhard Gruber ; Sylvia Gruber. - Donauwörth : Auer, 1997. - 40 S

    Daniel : Jn einem Sing-Spiel vorgestellet auf dem grossen Braunschweigischen Schau-Platz / [Georg Kaspar Schuermann; Johann Christian Knorr v. Rosenroth]

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    Erm. Komp.: G.K. Schuermann; erm. Textverf.: Joh. Chr. Knorr v. RosenrothVorlageform d. Erscheinungsvermerks: Braunschweig/ In Verlegung Caspar Grubers seel. nachgel. Wittw

    To Camp Gruber

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    Photograph used for a story in the Oklahoma Times newspaper. Caption: "To Camp Gruber Capt. Byrne A. Bowman, Oklahoma City attorney and reserve officer, was graduated Tuesday from the judge advocate general's school in Washington, D. C.

    Control of the so called leaf loss of European beech (Faguss sylvatica L.) by the weather

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    The annual assessed leaf losses and recorded leaf masses of the beech trees are narrowly correlated with the local or regional climate resp. weather (Tab. 1, 3, 4). Due to the multiannual development of shoots and leaves on beech (Fig. 1) the weather/climate of several years during this development influences the leaf canopy and leaf loss of a stand. The multiannual weather index MAWI (KINDall) composed of the weather efficient monthly dates of local and regional precipitation, air temerature and sunshin duration (also global radiation, relative humidity, water saturation deficit) of four years can be roughly correlated (r(2) > 0,98) to the leaf mass and assessed leaf loss of a stand. Therefore laef mass and leaf loss is controlled by MAWI (Tab. 1, 3, 4; Fig 2, 4, 5). The high percentage of preformation of leaf mass and leaf loss during the developmental periods is strongly influenced by the weather data allows a prediction with high pricicion (Tab. 2, 5, 6; Fig. 3, 6, 7). The leaf loss of the stand Harste 78 is narrowly correlated to the multiannual transpiration stress factor (tsf), which is composed of the water saturation deficit of the air, the global radiation and the precipitation (r(2) = 0,8; s. Tab. 7, Fig. 8-10). The author points out on the great importance of the woods and the poor information about them and that the science of woods and forests must be expanded, long-term installed and better organized

    Control of the so called leaf loss of European beech (Faguss sylvatica L.) by the weather

    No full text
    The annual assessed leaf losses and recorded leaf masses of the beech trees are narrowly correlated with the local or regional climate resp. weather (Tab. 1, 3, 4). Due to the multiannual development of shoots and leaves on beech (Fig. 1) the weather/climate of several years during this development influences the leaf canopy and leaf loss of a stand. The multiannual weather index MAWI (KINDall) composed of the weather efficient monthly dates of local and regional precipitation, air temerature and sunshin duration (also global radiation, relative humidity, water saturation deficit) of four years can be roughly correlated (r(2) > 0,98) to the leaf mass and assessed leaf loss of a stand. Therefore laef mass and leaf loss is controlled by MAWI (Tab. 1, 3, 4; Fig 2, 4, 5). The high percentage of preformation of leaf mass and leaf loss during the developmental periods is strongly influenced by the weather data allows a prediction with high pricicion (Tab. 2, 5, 6; Fig. 3, 6, 7). The leaf loss of the stand Harste 78 is narrowly correlated to the multiannual transpiration stress factor (tsf), which is composed of the water saturation deficit of the air, the global radiation and the precipitation (r(2) = 0,8; s. Tab. 7, Fig. 8-10). The author points out on the great importance of the woods and the poor information about them and that the science of woods and forests must be expanded, long-term installed and better organized

    Conceptual replication of Gruber et al. (2014)

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    Reward anticipation has been linked to enhanced memory for incidentally encoded stimuli (e.g., Gruber et al., 2014; Wittmann et al., 2005). The current study aims to conceptually replicate the findings of Gruber et al. (2014) in an online sample. References: Gruber, M. J., Gelman, B. D., & Ranganath, C. (2014). States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit. Neuron, 84(2), 486-496. Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H. J., & Düzel, E. (2005). Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron, 45(3), 459-467

    Orpheus Und Euridice : Jn einem Sing-Spiel Auf der Braunschweigischen Schau-Bühne vorgestellet / [Komp.: Reinhard Keiser. Übers.: Friedrich Christian Bressand. Textverf. d. ital. Orig.: Aurelio Aureli].

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    Erneute Umarbeitung der Oper "Orpheus" (erschienen in 1. dt. Fassung 1690 als Fünfakter mit Kompositionen von Antonio Sartorio, dann 1699 in 2 Dreiakter aufgeteilt u. von Reinhard Keiser neuvertont, schließlich 1702 wieder als Ganzes in 3 Akten)Auch als elektron. Dokument vorh.Textverf., Komp. u. Übers. ermitteltFingerprint erstellt nach Ex. der HAB Wolfenbüttel und der ULB Sachsen-AnhaltSignaturformel: [2] A-C4 D2 C-E4Vorlageform des Erscheinungsvermerks: Braunschweig, Jn Verlegung Caspar Grubers seel. nachgel. Wittwe, und Erben
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