323,118 research outputs found
Potential of Bone Marrow Stromal Stem Cells to Repair Bone Defects and Fractures
No full textStan Gronthos and Andrew C.W. Zannettinohttp://www.amazon.com/Progress-Stem-Cell-Research-Prasad/dp/1604560657/ref=sr_1_1?ie=UTF8&s=books&qid=1260141218&sr=1-
Stem cells and future periodontal regeneration
No full textNi-Hung Lin, Stan Gronthos and P. Mark Bartol
alpha-l-Iduronidase transduced mesenchymal stem cells improve the behavioral deficits in mucopolysaccharidosis type I mice
No full textAbstract not availableMatilda R. Jackson, Ainslie L.K. Derrick Roberts, Stan Gronthos, Sharon Byer
The role of the chemokine CXCL12 in osteoclastogenesis
No full textThe chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism. Although considered an important factor in normal bone metabolism, recent studies implicate CXCL12 in the pathogenesis of several diseases involving the skeleton, including rheumatoid arthritis and cancers that metastasize to bone. Recent studies have highlighted an emerging role for CXCL12 in the processes of physiological and pathological bone remodelling.Stan Gronthos and Andrew C.W. Zannettin
Ephb and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells
No full textPoster Presentation - P1192Thao Nguyen, Stan Gronthos, Agnes Arthur, and John Haybal
Tissue engineered periodontal products
No full textAttainment of periodontal regeneration is a significant clinical goal in the management of advanced periodontal defects arising from periodontitis. Over the past 30 years numerous techniques and materials have been introduced and evaluated clinically and have included guided tissue regeneration, bone grafting materials, growth and other biological factors and gene therapy. With the exception of gene therapy, all have undergone evaluation in humans. All of the products have shown efficacy in promoting periodontal regeneration in animal models but the results in humans remain variable and equivocal concerning attaining complete biological regeneration of damaged periodontal structures. In the early 2000s, the concept of tissue engineering was proposed as a new paradigm for periodontal regeneration based on molecular and cell biology. At this time, tissue engineering was a new and emerging field. Now, 14 years later we revisit the concept of tissue engineering for the periodontium and assess how far we have come, where we are currently situated and what needs to be done in the future to make this concept a reality. In this review, we cover some of the precursor products, which led to our current position in periodontal tissue engineering. The basic concepts of tissue engineering with special emphasis on periodontal tissue engineering products is discussed including the use of mesenchymal stem cells in bioscaffolds and the emerging field of cell sheet technology. Finally, we look into the future to consider what CAD/CAM technology and nanotechnology will have to offer.P. M. Bartold, S. Gronthos, S. Ivanovski, A. Fisher, D. W. Hutmache
Methods for the purification and characterization of human adipose-derived stem cells.
No full textMethods in Molecular Biology; no. 702Peripheral adipose tissue contains a population of clonogenic precursor cells referred to as adipose-derived stem cells (ASC) that retain the capacity to differentiate into multiple cell types including osteoblasts, adipocytes, chondrocytes, myocytes, and neuronal cells following ex vivo expansion. Recent studies have demonstrated that ASC are most likely derived from a perivascular niche within highly vascularised fat tissue, analogous to different mesenchymal cell populations identified in other tissues throughout the body. The following chapter describes techniques to prospectively isolate clonogenic ASC from adult human adipose tissue using antibodies directed against perivascular markers and methods to immunophenotypically characterize their ex vivo expanded progeny.Stan Gronthos and Andrew C.W. Zannettin
Cellular therapy for cardiovascular disease Part 1 - Preclinical insights
No full textPeter J Psaltis, Stan Gronthos, Stephen G Worthley and Andrew C.W. Zannettin
Cellular therapy for cardiovascular disease Part 2 - Delivery of cells and clinical experience
No full textPeter J Psaltis, Stan Gronthos, Stephen G Worthley and Andrew C.W. Zannettin
Multiphasic scaffolds for periodontal tissue engineering
No full textFor a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate biomechanical stability over time. A critical requirement is the ability to promote the formation of functional periodontal attachment between regenerated alveolar bone, and newly formed cementum on the root surface. This review outlines the current advances in multiphasic scaffold fabrication and how these scaffolds can be combined with cell- and growth factor-based approaches to form tissue-engineered constructs capable of recapitulating the complex temporal and spatial wound-healing events that will lead to predictable periodontal regeneration. This can be achieved through a variety of approaches, with promising strategies characterized by the use of scaffolds that can deliver and stabilize cells capable of cementogenesis onto the root surface, provide biomechanical cues that encourage perpendicular alignment of periodontal fibers to the root surface, and provide osteogenic cues and appropriate space to facilitate bone regeneration. Progress on the development of multiphasic constructs for periodontal tissue engineering is in the early stages of development, and these constructs need to be tested in large animal models and, ultimately, human clinical trials.S. Ivanovski, C. Vaquette, S. Gronthos, D.W. Hutmacher, and P.M. Bartol
- …
