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Electric shock-like sensations (paresthesia) on venlafaxin discontinuation
No full textA hospitalized 24-year-old female patient with severe recurrent depression experienced very unpleasant electric shock-like paresthesias in the extremities. The symptoms lasted seven days and probably can be considered as a venlafaxin discontinuation syndrome. The symptoms relieved on reexposition with venlafaxin. This case report shall call attention to the basic relevance of discontinuation syndromes as adverse drug reactions. In addition, the clinical relevance of unusual paresthesias shall be emphasized
Asymptomatic bradycardia associated with amisulpride
No full textWell-known adverse effects of amisulpride include nausea, insomnia or tiredness, gastrointestinal, extrapyramidal and endocrine symptoms. Cardiac disorders, however, appear to be an extremely rare complication of the drug. Only a few case reports on this complication have been published so far, which deal with QT prolongation, hypotension, hypertension and palpitations. Bradycardia has not yet been mentioned. Here, we will report on a case of asymptomatic bradycardia that developed subsequent to therapeutic doses of amisulpride in a 25-year-old male patient with chronic paranoid-hallucinatory schizophrenia. The patient had been rehospitalized for an acute exacerbation of the psychosis. When the patient failed to respond at the beginning of hospitalization, the treatment was changed from clozapine to amisulpride. After a complete switchover to amisulpride, the patient's ECG showed sinus bradycardia and QT prolongation. When the daily dose of amisulpride was reduced from 800 mg/d to 600 mg/d, the patient's ECG quickly normalized (including blood pressure and pulse rate) within a few days. The patient did not report any cardiovascular-related complaints. Since the cardiovascular-specific diagnostics did not yield any indicative results, bradycardia may be a rare complication of amisulpride treatment
Electric shock-like sensations (paresthesia) on venlafaxin discontinuation
No full textA hospitalized 24-year-old female patient with severe recurrent depression experienced very unpleasant electric shock-like paresthesias in the extremities. The symptoms lasted seven days and probably can be considered as a venlafaxin discontinuation syndrome. The symptoms relieved on reexposition with venlafaxin. This case report shall call attention to the basic relevance of discontinuation syndromes as adverse drug reactions. In addition, the clinical relevance of unusual paresthesias shall be emphasized
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