2,274 research outputs found
Galactic Archaeology in the Era of Large Surveys
Full text linkIn this Thesis, I study the formation and chemical evolution of the Milky Way by means of new and detailed chemical evolution models in the light of the most recent data from Galactic surveys and missions.
Indeed, we are in a golden era for Galactic Archaeology thanks to the advent of several Galactic spectroscopic surveys and missions. In fact, in recent years, many spectroscopic surveys and projects have been developed in order to study the formation and evolution of our Galaxy. Moreover, Gaia mission is enhancing the value of these surveys. In this way, detailed stellar abundances of stars in the Milky Way can be measured.
Then, by means of detailed chemical evolution models it is possible to predict the chemical abundances expected in the stars of each Galactic component: the halo, the thick disc and thin discs, and the bulge. From the comparison between data and model predictions, it is possible to reconstruct the history of star formation occurred in each component, and thus the history of formation and evolution of the entire Galaxy, to which this Thesis is devoted. In Chapter 1, I give a general introduction about the Milky Way and its main Galactic components, and then I present the goal and the structure of this Thesis. In Chapter 2, I describe in details the method used in this work, i.e. Galactic chemical evolution models with the fundamental ingredients and complete equations of chemical evolution. In successive Chapters, I show the original results of my work. In particular, in Chapter 3, I present the chemical evolution models that I developed for the Galactic thick and thin discs in the solar neighbourhood, both a revised two-infall model and the parallel one. In Chapter 4, I extend the study also to the other Galactocentric distances and explore abundance gradients along the Galactic thin disc, investigating the main physical processes affecting them. In Chapter 5, I present the chemical evolution models implemented for the Galactic bulge and discuss the origin of different stellar populations in this Galactic component from chemical abundances. In Chapter 6 and 7, I apply the reference models developed for the Galactic discs and bulge to study the chemical evolution from lithium to europium, respectively. Finally, in Chapter 8, I summarize the main conclusions of this Thesis and outline future prospects arising from them
Acque e fontane a Milano (1922-1942). Mediare funzioni e memoria storica
No full textBetween the two world wars, not only architecture but also public space (for providing services to citizens) and restoration (for seeking a historical identity), were often tools of propaganda. Exploring the works professionals, even minor ones, such as Alessandro Minali, allows us to grasp affiliations and oppositions, links and rifts. The management of water in the Milan the Ventennio, starting from the coverage of the Navigli up to the design of a network of public fountains, suggests a cross fields overview
Memorie sovrapposte. Durata e mutamento nel Monumento ai Martiri per la Libertà di Fondotoce.
No full textBeing the chronology of this War Memorial in Fondotoce recently published it is easier focusing on contours and adaptations. The paper aims: on one hand, to underline the references of a cultured and refined designer not extraneous to the theme of war memorials and funerary
architecture since the early post-war period; on the other, to evaluate, also in the light of the
sculptures and architectures that have arrived, if the symbolic forms and compositions proposed by him lend themselves to transmitting lasting meanings and already bear within themselves the forms of change
Bergamo 1796-1797. Monumenti ambivalenti nella ‘guerra per simboli'
No full textSome projects of theatres in Bergamo and of a small for the ex-church of St. Augustine are attributed to Leopoldo Pollack. To deepen this statement with new documents apart from those which are well known but now lost, plenty of unpublished data are here collected. They do not refer only to building acts, nor to that unique place, as they show the intention for spreading new symbols and a new urban image pursued by the transient Democratic
Republic in Bergamo (1796-1797)
"The love that made hell, paradise." Ouida re-writing the Paolo and Francesca theme in Held in Bondage
No full textThe bestselling Victorian author Ouida reveals in her novels, and, in particular, Held in Bondage, an extraordinary knowledge od Dante, by using characters and themes from the Commedia. The Paolo and Francesca theme actually constitutes part of the plot of the novel and is to be found in many of her other works, short stories and non-fiction writing
Predicting Metabolic Reactions with a Molecular Transformer for Drug Design Optimization
No full textMetabolism prediction is a crucial step of drug development, as the biotransformations a drug candidate undergoes inside the human body can affect the clinical outcome. Computer-aided drug design has been extensively employed to speed up the process and enhance its efficiency and effectiveness, but among the investigated areas, metabolism has received less attention. This project aimed at leveraging machine learning to analyze large metabolic datasets, make predictions, and recognize patterns, in order to fill this knowledge gap and enhance our understanding of metabolism and its impact on drug development. To achieve this goal, we developed a Deep Learning model for metabolism prediction using natural language processing techniques trained on molecular string representations, i.e., Simplified Molecular Input Line Entry Systems (SMILES) strings. To this end, we employ a Molecular Transformer, because of its ability to capture sequential and contextual information within strings (in this case, SMILES) enabling the learning of complex relationships. The transformer was trained using a high-quality dataset, MetaQSAR, from which we derived approximately 100000 instances of metabolic reactions. In this work, we investigate whether the Transformer architecture bears the potential to learn a mapping between the input molecular structures and their corresponding metabolites, in order to expedite drug discovery and improve patient safety
HERStory Makers 2023: Francesca Fotheringham
No full textFrancesca Fotheringham is a postdoctoral research associate at the University of Edinburgh studying educational psychology with a focus on neurodiversity. She took part in HERStory Makers 2023.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON Francescasupported by the Engineering & Physical Sciences Research Council [grant number EP/X020762/1].Author contributions to contentFrancesca conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, added subtitles, and reduce video length to below Twitter/X limit of 2 mins and 20 secs.</p
Medicina illuminata. La Biblioteca Lancisiana di Roma
No full textL'articolo presenta i codici miniati della Biblioteca Lancisiana di Roma. La prima parte, del coautore, è dedicata alla Biblioteca. La seconda parte, di F. Manzari, tratta dei manoscritti miniati, costituiti da due codici con le opere di Avicenna e dal Liber fraternitatis della Confraternita dell'Ospedale di Santo Spirito in Sassia a Roma.The article introduces the illuminated manuscripts of the Biblioteca Lancisiana in Rome. The first part of the article, by the co-author, is dedicated to the Library. The second part, by Francesca Manzari, illustrates the manuscipts; these are two manuscripts with the works of Avicenna and the Liber fraternitatis of the Confraternity of the Hospital of Santo Spirito in Sassia in Rome
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