188,888 research outputs found
Crisi e crollo dei regimi non democratici. Condizioni e tendenze nella terza ondata.
No full textUna analisi comparata del cambiamento politico in 83 paesi, valutando fattori interni e fattori internazionali
Pharmacological rationale for tapentadol therapy: a review of new evidence
No full textPatrizia Romualdi,1 Mariagrazia Grilli,2 Pier Luigi Canonico,3 Massimo Collino,4 Anthony H Dickenson5 1Department of Pharmacy and Biotechnologies Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy; 2Laboratory of Neuroplasticity, Department Pharmaceutical Sciences, University of Piemonte Orientale, Novara 28100, Italy; 3Departiment of Pharmacological Sciences, University of Piemonte Orientale, Novara 28100, Italy; 4Department of Drug Science and Technology, University of Turin, Turin 10121, Italy; 5Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK Abstract: Chronic pain could be considered as a neurological disorder. Therefore, appropriate selection of the therapy, which should consider the pathophysiological mechanisms of pain, can result in a successful analgesic outcome. Tapentadol is an analgesic drug which acts both as a μ-opioid receptor (MOR) agonist and as a noradrenaline reuptake inhibitor (NRI), thereby generating a synergistic action in terms of analgesic efficacy, but not for the burden of adverse effects. Therefore, tapentadol can be defined as the first “MOR-NRI” drug. This molecule holds the potential to address at least some of the current limitations of analgesic therapy due to its unique mechanism of action and has shown to be safe and effective in the treatment of chronic pain of cancer and noncancer etiologies including nociceptive, neuropathic and mixed pain. In particular, the MOR component of tapentadol activity predominantly allows for analgesia in nociceptive pain; on the other hand, the NRI component contributes, now in a predominant manner, for analgesic efficacy in cases of neuropathic pain states. This paper will discuss recent pieces of evidence on the pathophysiology of pain, the background on tapentadol and then present some new studies on how the unique mechanism of action of tapentadol provides a key role in its analgesic efficacy in a number of pain states and with a favorable safety profile. Keywords: tapentadol, neuropathic pain, pain chronicizatio
New domestic landscapes: a collaborative autoethnography in times of Coronavirus in Italy
No full textIn this article we present the results of research on transformations of everyday domestic life during the first Italian coronavirus lockdown.
Covid-19 has shaken many of our convictions; it has “suspended time,” forcing us to live in a condition of uncertainty. People have had to re-think their priorities and the ways they live in and use domestic space, managing a relationship of power and agency between themselves and the house. The house, as a tyrannical agent, forced people to adapt to it, and to act as a consequence of changes dictated by Covid-19. This redefinition process has brought to light themes of great anthropological interest: new rituals, new definitions of cohabitation spaces, new needs and new fears.
As it was impossible to conduct classical fieldwork, we chose to use the method of collaborative autoethnography, involving a group of 30 students in our research. We were thus able to observe changing everyday habits and the reorganization of spaces for purposes of work or sociality, as well as changes in relations with the outside world, mediated by social networks
"Don Quijote escribe cartas"
No full textSi studia il "paradosso" per cui don Quijote coltiva l'epistolografia contravvenendo alla definizione di Guevara che esclude il "loco" dall'esercizio dell'arte delle lettere, riserva privilegiata dei saperi umanistiWe study of the "paradox" according to which don Quijote cultivates the epistolography by transgressing Guevara's notion that excludes the "loco" from the practice of humanities, gold reserve of humanistic learnin
Book reviews: John Aerni-Flessner's Dreams for Lesotho: Independence, Foreign Assistance, and Development Notre Dame: University of Notre Dame Press, 2018)
No full textJohn Aerni-Flessner, Dreams for Lesotho: Independence, Foreign Assistance, and Development. Notre Dame: University of Notre Dame Press, 2018, p. 284, Hardcover 43.99, eBook (EPUB) $43.99, ISBN-10: 0268103615; ISBN-13: 978-0268103613
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