5,235 research outputs found

    Development of Cardiovascular Risk Assessment Model for People with Type 2 Diabetes in Oman

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    Type 2 diabetes mellitus (DM) is one of the most common chronic diseases globally, with worldwide prevalence of 8.3%. Due to its long-lasting nature and high risk of complications, the burden of type 2 DM is expected to rise. Patients with type 2 DM have an estimated two-to-six fold higher risk of developing cardiovascular disease (CVD) compared to the general population. Moreover, CVD is considered the leading cause of morbidity and premature mortality in type 2 diabetic patients. CVD risk assessment tools in general are mathematical models or charts used to estimate the risk of a CVD event in an individual. CVD risk estimation is important to plan the initiation of preventive and therapeutic measures for CVD prevention including anti-lipid, anti-hypertensive and anti-platelet therapies, as well as to plan appropriate health education. Various professional guidelines for the management of type 2 DM have advocated the use of CVD risk assessment tools to estimate CVD risk among type 2 diabetic patients using traditional CVD risk factors such as hypertension (HTN), dyslipidemia, high glycosylated hemoglobin (HbA1c), albuminuria, obesity, smoking status, and family history of CVD. However, most of the existing CVD risk assessment tools were derived from Western populations, with very few developed for East Asian populations.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)School of Medical ScienceGriffith HealthFull Tex

    Evaluation of cognitive-behavioral therapy-based intervention on type 2 diabetes patients with comorbid metabolic syndrome - a randomized controlled trial

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    Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes mellitus (DM) and its prevalence in China has increased rapidly. Poor control of DM leads to a series of complications, which seriously impair patients' quality of life. Importantly, the proportion of T2DM patients who meet the diagnostic criteria for metabolic syndrome (MS) is very high. The coexistence of the two diseases increases DM complications and the incidence of cardiovascular and cerebrovascular diseases. Individuals that have T2DM and MS experience a higher incidence of depression and anxiety symptoms than the general population. These negative emotions create obstacles in effectively managing blood glucose levels. In addition, T2DM and MS patients commonly display suboptimal self-care behaviors, which can be attributed to negative emotions, insufficient knowledge about diabetes, or cognitive biases linked to the disease. Cognitive behavioral therapy (CBT) aims to change the non-adaptive cognitions and behaviors of patients by developing therapeutic alliances, psychological education, cognitive reconstruction, and behavioral activation. Previous studies have applied it to the prevention and treatment of DM and MS and found positive effects. However, there have been few studies on the coexistence of two or more conditions. To address this gap, this study aimed to conduct a randomized controlled trial (RCT) to explore the effectiveness of CBT on the improvement of health outcomes in T2DM patients who have comorbid MS. This study represents the pioneering effort to explore the effectiveness of CBT in diabetes patients with coexisting MS. Additionally, the innovative integration of both face-to-face and remote intervention methods adds a novel dimension to this research. Furthermore, the study encompasses a diverse array of health outcome, including physiological indicators, psychological indicators, behavioral indicators, quality of life, and sleep quality. Aims: This study had three primary objectives: (1) to evaluate the effectiveness of CBT in improving health outcomes for patients who have diabetes, hypertension, and coronary heart disease (CHD) using existing published studies, (2) to use baseline data to identify the variables that may be related to emotions, behaviors, and cognition in patients who have T2DM and comorbid MS to design targeted CBT intervention programs for the cohort of patients who have T2DM and comorbid MS, and (3) to investigate the impact of the CBT intervention program designed for this study on physiological, psychological, and behavioral indicators as well as its influence on sleep quality and the overall quality of life of patients who have T2DM and comorbid MS.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)School of Medicine & DentistryGriffith HealthFull Tex

    Understanding the Contribution of Situation Awareness to Decision Making by Medical/Surgical Nurses for Pressure Injury Prevention in Nursing Practice

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    Situation awareness (SA) has been developed in occupations other than nursing to improve decision making (DM) for optimal performance and outcomes. There are some studies exploring the use of situation awareness by nurses in simulated settings but few have examined SA in clinical practice. Because of this paucity of evidence nurses’ use of situation awareness in practice is not fully understood. Studies examining decision making by nurses have indicated that clinical decisions arising from a lack of awareness of patient needs in busy, complex clinical environments can compromise care. In ward environments, compromised care often results in the omission of ‘basic’ nursing interventions which may include pressure injury prevention. This thesis explored the use of situation awareness by nurses in medical/surgical wards as the precursor to decision making and the influences on situation awareness whilst making pressure injury prevention decisions in practice.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)School of Nursing and MidwiferyGriffith HealthFull Tex

    Nitrogen Cycling in Leucaena Alley Cropping

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    Field experiments were conducted on an Alfisol in the semi-arid tropics of northern Australia to investigate nitrogen (N) cycling in the leucaena (Leucaena leucocephala) alley cropping system. This is a farming system in which maize (Zea mays L.) is grown in alleys formed by leucaena hedgerows spaced 4.5 metres apart. Mineralization of N from Ieucaena (prunings) and maize residues was studied under field conditions. Response of maize growth to addition of N fertilizer and plant residues was evaluated both in field plot and microplot experiments. The fate of fertilizer N and leucaena N was examined over four consecutive seasons. The decomposition (loss of mass) of dry, cut 15N-labelled leucaena residues differed from that of intact fresh leucaena prunings in the first cropping season although no difference was detected after one year. At the end of one cropping season, 3 months after application, 58-72% of 15N-labelled leucaena had decomposed compared to only 34-36% of fresh leucaena prunings. Similar trends occurred at 20 and 52 days after application. The extent of decomposition of fresh leucaena prunings (28-33%) was similar at two loading rates (2.4 and 4.7 t DM ha -1) by 3 months after addition. About 72% of young 15N labled maize residues was decomposed by 3 months after addition in the presence of fresh leucaena prunings. Decomposition of 15N-labelled leucaena residues and unlabelled fresh prunings was 91% and 88% respectively 14 months after addition. After 2 years the corresponding values were 96% and 94%. When N content of the recovered residues was taken into account, the values were 95% and 94% after 14 months, and the same (97%) after 2 years. Maize yield and N uptake were significantly increased following addition of either unlabelled fresh leucaena residues or 15N-labelled thy Ieucaena residues. Application of N ferilizer produced a thither increase in the presence of the residues. The maize yield and N uptake with the 15N-labelled leucaena were not different from those with the unlabelled residues. There was a significant positive interaction between N fertilizer and leucaena prunings which increased maize production. Addition of maize residues decreased the yield and N uptake of maize compared with that obtained in the presence of N fertilizer at 40 kg N ha~1 and leucaena residues (2.4 t DM ha-1). There was a marked residual benefit of N fertilizer applied in the first season at 36 kgN hat in the presence of leucaena prunings on the second maize crop yield and N uptake, but not on the third crop. However, a significant residual benefit of leucaena prunings added in the first season was found in DM yield and N uptake of the second and third maize crop. The short-term fate of 15N applied in plant residues was examined during two separate cropping seasons. By 20 days after application of separate 15N-labelled leucaena leaves, stems and petioles, 3-9% of the added 15N could be found in maize plants, 33-49% was in surface residues, 36-48% in the 2 m soil proffle and 0.3-22% unaccounted for. In a separate experiment when leucaena components were not separated, 5% of 15N applied in leucaena residues was taken up by maize 52 days after addition, 45% was in residues, 25% was in soil and 25% was unaccounted for. Jn another experiment, maize recovered 6% of added leucaena 15N after 2 months, 39% remained in residues, 28% was in soil and 27% was not recovered. Incorporation of 15N-labelled leucaena residues in the soil did not increase recoveiy of leucaena 15N by maize compared with placement of the residues on the soil surface. By the end of one cropping season (3 months after application), 9% of added 15N was recovered by maize from 15N-labelled leucaena. There was a similar 15N recoveiy from 15N-labelled maize residues applied as mulch at 1.7 t DM ha1 together with unlabelled leucaena prunings at 2.4 t DM ha ~. In both cases, 30-32% of added 15N was detected in soil, 28% in residues, and 31-34% apparently lost. The short-term fate of fertilizer 15N was different from that of 15N added in plant residues. In a 52-day experiment, maize recovered 65-79% of fertilizer 15N applied at low rates (6.1 and 12.2 kg N ha -1) in the presence of leucaena prunings, 21-34% was present in soil, and less than 1% was not recovered. By 2 months after application, recoveiy of fertilizer 15N by maize was 41% from N fertilizer added at 80 kg N ha -1, 35% from N fertilizer at 40 kg N ha -1 in the presence of leucaena prunings, and 24% from N fertilizer at 40 kg N ha -1 in the presence of maize residues and leucaena prunings. The corresponding deficits (unaccounted-for 15N) were 37%, 38% and 47% respectively. A small but significant amount of the fertilizer 15N was present in the unlabelled leucaena residues (3%) and in the mixture of unlabelled leucaena and maize residues (7%) present on the soil surface. However, application of the plant residues did not affect recoveiy of the fertilizer 15N in soil (21-24%). When N fertilizer was applied at 40 kg N hi1 in the presence of leucaena prunings, 43% of fertilizer 15N was recovered by maize at the end of cropping season, 20% in soil, 2% in residues, and 35% unaccounted for. The long-term fate of fertilizer 15N was compared with that of leucaena 15N in an experiment over four cropping seasons. In the first season, maize tops recovered 50% of the fertilizer 15N but only 4% of the leucaena 15N. In the second, third and fourth seasons, maize (tops + roots) recovered 0.7%, 0.4% and 0.3% of the initial fertilizer 15N compared with 2.6%, 1.8% and 1.4% of the initial leucaena 15N. In the second, third and fourth seasons, recovery of the initial fertilizer 15N (12-14%) in soil was much lower than that of the initial leucaena 15N (38-40%). There was no further loss of the fertilizer 15N after the first season. However, the cumulative 15N deficit for the leucaena 1N in the first two seasons was 50%--thissuggested an additional loss of 23% since the end of the first season. There was no further loss of 15N from either residual fertilizer 15N or residual leucaena 15N in the third and fourth seasons. In conclusion, application of leucaena prunings could substantially increase maize yield and N uptake although some supplementary N fertilizer may be required to achieve maximum crop yield. Maize recovered only a small amount of added leucaena N in the first year. Most of the leucaena residue N was present in the soil and remaining residues after one season. This residue N would be gradually available for plant uptake by subsequent crops. Of course, annual additions of leucaena prunings would appreciably increase the pool of available N over time. Thus, application of leucaena prunings could substantially improve soil fertility in the long term.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)Division of Australian Environmental StudiesFull Tex

    Ledger pages, circa 1881-1900, part 1

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    Ledger pages, circa 1881-1900 (Ledger pages are from a ledger with a broken binding, in two parts with some loose pages; cover and some pages are missing.)Ledger includes entries by multiple individuals on different topics, but appears to have been primarily compiled by Marion P. (M. P.) Griffith in his capacity as a notary public, church elder, and Postmaster of McDowell, Missouri.[Page 1] 887 Oct 1st Bot condition Powder 50 Bot [lixxxx] 50 [Pxx] [Pxxx] fine silk 55 {xhxx] 5 [xxxxx] + collar 2 Pin shove 75 1 Bot bone + nen 50 [Kxxxxx] + [xat] 20 shall + fire crackers 25 [xxxxx] Pomers daughter age 18 single physical strength good 2[x] Jess [Wilxxx] [xxx] 18 years single Jan 26 LH Morphis Dr [xx] [xx] [pxx] [xxxxx] 20 1 bot red [xxxxx] ink 10 2 Stamped Envelops 5 29 [Remxxxed] for [xx] [bxxxxx] 82 Direct us office [xxxxxx] Rent of office to Morphis 1 00 Feb 5" [xx] Letter Paper 15 1 50 [xxxx] [xxxx] Feb 9" 1889 No 19827 [hoxx] + [xxxxx]ents [xxxxx] [xx] 120certificateNo5189[Hxx][2x][lexxxxxer]ofThe[xxxxxxx][wordcrossedout][Line36tornandincomplete][Page2]M1889Feb12"issuedbytheDept[xx][crossedout]usa[Wxxxxx][xon][xxty][xx]onedraftfor120 certificate No 5189 [Hxx] [2x] [lexxxxxer] of The [xxxxxxx] [word crossed out] [Line 36 torn and incomplete] [Page 2] M 1889 Feb 12" issued by the Dept [xx] [crossed out] us a [Wxxxxx] [xon] [xxty] [xx] one draft for 12 00/100 to the order of [lx] + W B King one draft to elemant for 10800/100signed[xxx]SWShinnauditor3dAuditorsoftenD6AllenDr131/2[xxx]stamped[x]14[xho]AHaglerDr25byLaMorphis1889Agust12Paid[xxx][N.x.][xxxer]75[xxll]108 00/100 signed [xxx] SW Shinn auditor 3d Auditors often D6 Allen Dr 13 1/2 [xxx] stamped [x] 14 [xho] A Hagler Dr 25 by L a Morphis 1889 Agust 12 Paid [xxx] [N.x.][xxxer] 75 [xxll] 6 [Rexxxtted] 7 N. Elmer 3 25 [oday] Barry [xolm] April 13 M.B. Webb paid 1 00 for [cassbill] [Dunoxx] 17 [Endoud] [xxx] Ray for Webb 00 in case of MB [Wxxx] 24 S B Rainey to [Bxx] US [xxxx] 20 June 18 R hall to Bx [Pixx] 20 22 Ed. Jackson [xx] cords 15 Will Dyer Do [collax] .5 ch 12" Read of MP [xxxxxxxx] The M [x] Webb 1.00 for the [end of page torn] [Page 3] 1888 Post [xxxxx] Supplies [Bxxxined] of [xxxxx] Nov 17 to one 2 e Stamp 2 " 24 " 4 " " 8 " " " 54 Stamps 1 0 8 " " " 18 1 " 1 8 " " " 25 2 Envelope 5 4 " " " 25 Cords 2 5 " " " 25 wafers 2 8 " 27 26-10 Stamps 2 6 0 cancelations of 1/4 5 1 1 ending Dec 31 88 1261-1/3 = 4 2 0 Balder 9 1 1889 Jan 3 Stamps " 4 23-20 Stamps 4 6 " 23 one [Bxxxxx] Small 5 4 " " 25 cards 2 5 jine 30 With US Ended hand 13 22 Mail Rout No 28769 By a man an Lee deed in common form duty exanted and aknowledged and in the mean time shall permit said mason [Phullith] to [xxxxx] and [xxxxx] said premises for his own [me] then this obligation shall be said in witness where of the said parties of the few part have [herexxx] set there hand and [hole in letter] this 21st day of feb [ax]1896 [xxxxx] 7 Bradshaw [xxxxx] 6 Brawshaw J T Allcock [Nx] signed sealed + delivered [Bxxx] [xxx] [xx] [xxxxx] of E R [axxxxxxx] a [xxxx] [Page 4] W Frank [Roblyer] [Coxxxxed] [meh] 10 1889 + Paid in advance 1 50 April 13 7 [Roblyer] paid 1 50 [Bu] [oab] [xxxttled] 35 1889 [xoox] plate 35 May 13 By each [xxxxxx] 80 june 13 Do 1 50 Aug By order of HC Hutchens [xxxx] settled 13 00 + paid to Aug 13"90 Sept 27 Settled for HC Hutchens 2 00 [Rxed] by [caxx] 25 [xxxxx] {Roblyer} 1889 Sept 29 7 {Roblyer] [remooved] 1889 Oct 17 Paid WB [exxxith] 2 25 1890 April 1st [Rent] B7 [burros] per month 1 50 Jun 1890 23 Dr Burrow remooved July 11 Reid of MP [xxxith] 5 75 [x.B.][xx] Donald [Page 5] 9450/100inthe[Ruth][x]B[xxx][ez]1/2inaling[xxx]88bythat[xx]willpayhis94 50/100 in the [Ruth] [x] B [xxx] [ez] 1/2 in a ling [xxx] 88 by that [xx] will pay his 5 [Woo] of fil [xx] null pay 5[x]outofmine+3outofthereJuly188925[quill]returnedhomeLettersfromsenator7[x]cockellareasfollows[xxx]18901816[xxx]+15onpostofficemattersalso[xxx]S[xxxxxxons]letterof13thmaywithCockellsofsamedateallpertaningtopostoffice[xxxxxxx]+NoraGriffithwasbornedSep161885shehaslived[xx]yearsandahalfSheisintheforthreaderandspellingbookandwritingandgramerand[geography]andisagoingtogointhefifthnextyearwell[xx]closeIwrotethistoseeifnextyearthistimeifive[xxxxxxed]yoursrespectfulNoraGriffith[Page6]Expensesonhouse1889mch23hingesJBMeDonaldBoughtnails2452sashes160HCHutchens[xxxxxxed]405mch111889+worked10days1000[J.O.]Hutchens"7days700total1700caried405J.J.Griffithbotnails2521.05+M.P.Griffith25CarriedApril3rd[xxxx]workby[xxxxx]100July201893JoshHJohnsonCoK47t[xx][xxxx][xlainant]andhiswitnessestistfiedonhe10thJuly1893asfollowsSamLJohnson+HenryM[Sxxx]ofMadisonCo[minelamote][xx]BillofShop[xxxxx][xxxx]bonds[swts]32.5Rafters+[xxxxxx]380[xxxxx][xxxxx]1000+[haxxxx]25[xxxxx]275Nails145[xxxxxx]9pieces30[xx][xxxxxxx][haxxing][xxx]30[Page7]1889May16[xxxx][xxxx]J.W.HMay188915B.F.Slate[Coxxxemed]150PenmouthHallingbyState100[Hasxxxtzys]100+hallingloggs25June15SettlementshowsDrtoSlate75June.9.BFSlatetowork371/21121/2"16[Rexxmed]homefrommJantaylorContractedfee5 [x] out of mine + 3 out of there July 1889 25 [quill] returned home Letters from senator 7[x] cockell are as follows [xxx] 1890 18 16 [xxx] + 15 on postoffice matters also [xxx] S [xxxxxxons] letter of 13th may with Cockells of same date all pertaning to postoffice [xxxxxxx] + Nora Griffith was borned Sep 16 1885 she has lived [xx] years and a half She is in the forth reader and spelling book and writing and gramer and [geography] and is a going to go in the fifth next year well [xx] close I wrote this to see if next year this time if ive [xxxxxxed] yours respectful Nora Griffith [Page 6] Expenses on house 1889 mch 23 hinges JB Me Donald Bought nails 2 45 2 sashes 1 60 HC Hutchens [xxxxxxed] 4 05 mch 11 1889+worked 10 days 10 00 [J.O.] Hutchens " 7 days 7 00 total 17 00 caried 4 05 J.J.Griffith bot nails 25 21. 05 + M.P. Griffith 25 Carried April 3rd [xxxx] work by [xxxxx] 1 00 July 20 1893 Josh H Johnson Co K 47t [xx] [xxxx] [xlainant] and his witnesses tist -fied on he 10th July 1893 as follows Sam L Johnson + Henry M [Sxxx] of Madison Co [minelamote] [xx] Bill of Shop [xxxxx] [xxxx] bonds [swts] 3 2.5 Rafters + [xxxxxx] 3 80 [xxxxx] [xxxxx] 1000 + [haxxxx] 25 [xxxxx] 2 75 Nails 1 45 [xxxxxx] 9 pieces 30 [xx][xxxxxxx][haxxing][xxx] 30 [Page 7] 1889 May 16 [xxxx] [xxxx] J.W. H May 1889 15 B.F. Slate [Coxxxemed] 1 50 Pen mouth Halling by State 1 00 [Hasxxxtzys] 1 00 + halling loggs 25 June 15 Settlement shows Dr to Slate 75 June .9. BF Slate to work 37 1/2 1 12 1/2 " 16 [Rexxmed] home fromm Jan taylor Contracted fee 25 00 Capt [Pexxer] [Calipa] [Po] [Meloopen] Co [xll] [xxxx] Boat Lexington Navy [sevxne] [Missxxi] & [grxdson] Jes P. Griffith [Seamon] Dear [sie] a big snow in [Page 8] Expenses on house 1889 mch 23 hinges JB Me Donald Bought nails 2 45 2 sashes 1 60 HC Hutchens [xxxxxxed] 4 05 mch 11 1889+worked 10 days 10 00 [J.O.] Hutchens " 7 days 7 00 total 17 00 caried 4 05 J.J.Griffith bot nails 25 21. 05 + M.P. Griffith 25 Carried April 3rd [xxxx] work by [xxxxx] 1 00 July 20 1893 Josh H Johnson Co K 47t [xx] [xxxx] [xlainant] and his witnesses tist -fied on he 10th July 1893 as follows Sam L Johnson + Henry M [Sxxx] of Heary Lumber + 2 50 20 Plank 5 ft to the plank 1 75 by each 5 15 1 00 3. 15 Mill Bill 4 20 200 ft [xxxxxxx] 2 00 [xxxxxx] by D 2 20[75 written below] 5 45 May 7 1889 Bot of RS Burnett [xxx] 5 3/4 [xxx] + +paid 25 " 29 " Wrote [xxx] [xxxx] in case of jess B McDonald May Bot of W C Davenport [xxxxxxx] 1 42 Do 50+28. Total 3 20 [Page 9] 1889 May 16 [xxxx] [xxxx] J.W. H May 1889 15 B.F. Slate [Coxxxemed] 1 50 Pen mouth Halling by State 1 00 [Hasxxxtzys] 1 00 + halling loggs 25 June 15 Settlement shows Dr to Slate 75 June .9. BF Slate to work 37 1/2 1 12 1/2 " 16 [Rexxmed] home fromm Jan taylor Contracted fee 2500Aug3dPaidySStubblefield100aug9Slatedr38Aug3dpaidGW[xoxxly]cash50byshopwork50by[xxxx][lineacrosspage]75Slate197[sails]Feb11899Porter[xxx]TomShepheardpleasecomeandchipussomewoodandIwill[Page10]1880M.PGriffith[xxx]account[xxxxxded]1255[Axx]3Credit[xxy][beno]350905""tooats2[xxx]20""oneworkboardPaid15"""Coffee50"5"tobacco20Coffee50Soda5May3dTobaldue4854"Hat3010coffee50oil20June25coffee30June3d3penhose30"41ploneblade30703June3dcreditbyrents320Bycash200"4BalDueE.C.[xxxxxxx]183"tonails10lbs506pencils+tob158Nail2[xxx]108coffee50[xx]tonails5+1lbs30May251889LeasemadeC+O[xxx]10298[Lxxxed]oil.5[Page11]1889April13Paid[x]C[Cxxxxxxx]275Do130May3d[xxxxx]by[xxxx]350"11""200[linethroughline5]June3BalDue153"4tooneblowblade30"""Nails10pencils15"""Boltsto[xx]16"""10lbsNails45"6"tol10"8"Nails10"""coffee50"17"Nails25"19"tol10"""Nails10oats2030"[xxx]by2boardsXJuly2"onebox10404"3credbyRents200"Boards204[25writtenbelowonsameline]""Baldue179"23"stamps14"27"onebook25Aug3deedbyret218Aug3Settledinfull200todate18mailrouteNo28566Sept3"goods155"""credbyrent200""cash502.50[1.55writtenbelow]BaldueMP9595Sept3Settledtodate[Page12]May9CheckNo616188[xx]t.W.Long[eaxx]291889KnotagtbyJRMontgomeryMay1889PaidRMHagles250JulyHay[delxxxxd]500Wagon[tire]25Sept589onsettlementshowspaid775RMHagles[less]150025 00 Aug 3d Paid y S Stubblefield 1 00 aug 9 Slate dr 38 Aug 3d paid G W [xoxxly] cash 50 by shop work 50 by [xxxx][line across page] 75 Slate 197 [sails] Feb 1-1899 Porter [xxx] Tom Shepheard please come and chip us some wood and I will [Page 10] 1880 M.P Griffith [xxx] account [xxxxxded] 12 55 [Axx] 3 Credit [xxy][beno] 3 50 9 05 " " to oats 2 [xxx] 20 " " one workboard Paid 15 " " " Coffee 50 " 5 " tobacco 20 Coffee 50 Soda 5 May 3d To bal due 4 85 4 " Hat 30 10 coffee 50 oil 20 June 25 coffee 30 June 3d 3 pen hose 30 " 4 1 plone blade 30 7 03 June 3d credit by rents 3 20 By cash 2 00 " 4 Bal Due E.C.[xxxxxxx] 1 83 " to nails 10 lbs 50 6 pencils + tob 15 8 Nail 2 [xxx] 10 8 coffee 50[xx] to nails 5+1 lbs 30 May 25 1889 Lease made C+O [xxx] 10 2 98 [Lxxxed] oil .5 [Page 11] 1889 April 13 Paid [x] C[Cxxxxxxx] 2 75 Do 1 30 May 3d [xxxxx] by [xxxx] 3 50 " 11 " " 2 00 [line through line 5] June 3 Bal Due 1 53 " 4 to one blow blade 30 " " " Nails 10 pencils 15 " " " Bolts to [xx] 16 " " " 10lbs Nails 45 " 6 " tol 10 " 8 " Nails 10 " " " coffee 50 " 17 " Nails 25 " 19 " tol 10 " " " Nails 10 oats 20 30 " [xxx] by 2 boards X July 2 " one box 10 4 04 " 3 cred by Rents 2 00 " Boards 2 04[25 written below on same line] " " Bal due 1 79 " 23 " stamps 14 " 27 " one book 25 Aug 3 deed by ret 2 18 Aug 3 Settled in full 2 00 to date 18 mail route No 28566 Sept 3 " goods 1 55 " " " cred by rent 2 00 " " cash 50 2.50[1.55 written below] Bal due MP 95 95 Sept 3 Settled to date [Page 12] May 9 Check No 616188 [xx] t.W. Long [eaxx] 29 1889 Knot agt by JR Montgomery May 1889 Paid RM Hagles 2 50 July Hay [delxxxxd] 5 00 Wagon [tire] 25 Sept 5 89 on settlement shows paid 7 75 R M Hagles [less] 15 00 725 Dm hagles " " By cash 50 mr Eli Hannahs [xxxxxhers] paid 2 28[line through 2 28] Bal due 2 00 R M Hagles wheat 1/2 97 1/2 Sept 26 [Reed] of office stamps [xx] 57 Boys [setxxned] 13 Sept A D 1889 " 27 mrs [DxxxxitB] + Pills 20 " " C K Bynum Do 20 Sept 1889 29 F. Roblyer remooved oct 15 Paid R M hagles 2 50 Balance due 3.78 Oct 26 on settlement with a long 6 75 paid cash 5 oct R M hagles shop work 1 00 29 Reed of [xxxxx] 3 00 us F receipt & [xxxx] 5 00 Remitted Oct 18" 89 [Page 13] 1889 J B McDonald [Coxxxxed] Smith work total 3 05 June 1st 1889 settled [xx] to July 1st balance due McDonald 2 show 1 60 Nails 2 45 + Paid on shop up to July 1st in [xxxxxxx] 1 00 Home rent Paid to July 1st 1889 1 50 June 1st 1889 on Settlement due McDonald 1 551 M P Griffith J B McDonald July 3d on settlement for all rent + shop work to date full settlement to one + months rent in advance 2 50 Shop work to [xxxxx] 50+ 1 00 Aug 3d Settlement for slate 1 00 [marked out] paid cash [xxxxx] 60 To Aug 3d 1889 2 60 shop work 205 + all settled + paid to [xxxx] 3d 1889 Oct 26 Settled + [xxxx] 2 50 Nov 1889 3d 2 sashes + windows 1 50 shop work on wagon 30 [xxxx] + 250 [xx] Plank 1 75 earned Hinges + [xxxxx] 50 5 25 [Page 14] May 29 1889 Lumber for Building note 1st lot 2x4 348 2d 333 18 Peices 2x4 10 ft 123 18 " 2x4 10 " 192 36 " 2x4 12 " 188 40 " 2x6 18 " 720 2 " 1x4 16 " 10 2/3 2 " 1x4 14 9 1/3 Sheeting 700 ft June 3d S B [Remin] 1 June 3 House in Building " " [J S] [Kimman] 1 125 " 4 " 1 " " H C Hutchens 1 " 1889 5 [kimman] 1 " Hutchens 1 6 [Kimman] 1 " Hutchens 1 7 J S [Kimman] 1 Hutchens 1 [Ramer] 1 McDonald 1/2 Sat 8 J S [Kimman] 1 " S K [Rainy] 1 [Page 15] [Manage] of [WaCamon] Camon ti [xxxx] [peten] Jan 8 1881 [xxxxxxxxxx] by [xxx] Lee + [xxxxxx] by [xxxxx] [xxxxxx] Feb 20 1871 June 10 [Kimman] 1 11 [Kimman] 1 11 Hutchens 1 12 [Kimman] 1 Hutchens 1 J S [Kimman] total work on home 13 1/2 Po Botes all total 15 1/2 J S [Kimman] 125 9 15 1/2 15 1/2 625 125 18.75[Writtenupsidedownonthebottomofthepage]Jany18951appletrees2year5002appletrees2year5003appletrees2year300[xeah]appletrees1+3350Houseorchade7+9year2751925Peachorcharde3year10002925[4x4tabledrawninthemiddleofthepagewithxsdrawninthetoptworightboxesinthefirstcolumnandtheoutermostrightboxonthesecondcolumn][Page16][Comity]ofbassyslateofMissonnI[xanee][x]Halldo[xxxconly]smearor[affin]thatiwill[xxxx]fullyperformalltheduties[xxxxxed]of[mx]andandobtainfromeverything[xxxxxden]bythe[laxx]inrelationtothe[xxxxxxx][crossedout]mentof[portoftxxx]+portroadsnorththeU.S.andtheiwilhonestlyandtruly[accxxxx]forandtwiceoveranymoneygodsorotherthingsorparcellstowheretheybelongwhichmaycomeintomyposessionorcontrollandialsofurtherswearoraffirmthatiwillsupporttheconstitutionoftheUnitedStatessohelpmeGod[Vone.BHall][Subxxxibed]and[xxoom]tobeforethe[underiened]onthe2ddayofJulyAD1889MPGriffith[portmartes]atMcDovull[mx][Page17]July81889SettledwithRSBurnettinfullofallaccountsuptodateandfind2owesaidburnett18.75 [Written upside down on the bottom of the page] Jany 1895 1 apple trees 2 year 500 2 apple trees 2 year 500 3 apple trees 2 year 300 [xeah] apple trees 1 + 3 350 House orchade 7 + 9 year 275 1925 Peach orcharde 3 year 1000 2925 [4 x 4 table drawn in the middle of the page with x's drawn in the top two right boxes in the first column and the outermost right box on the second column] [Page 16] [Comity] of bassy slate of Missonn I [xanee] [x] Hall do [xxxconly] smear or [affin] that i will [xxxx] fully perform all the duties [xxxxxed] of [mx] and and obtain from every thing [xxxxxden] by the [laxx] in relation to the [xxxxxxx] [crossed out]mentof [portoftxxx] + port roads north the U.S. and the i wil honestly and truly [accxxxx] for and twice over any money gods or other things or parcells to where they belong which may come in to my posession or controll and i also further swear or affirm that i will support the constitution of the United States so help me God [Vone.B Hall] [Subxxxibed] and [xxoom] to before the [underiened] on the 2d day of July A D 1889 M P Griffith [portmartes] at McDovull [mx] [Page 17] July 8 1889 Settled with R S Burnett in full of all accounts up to date and find 2 owe said burnett 5.30 Nov 1889 2d The [Coxxxxion] 33 1/2 [xxx] [Reeliced] of MP Griffith 1/2 Dos small [xxx] bottles [sahation] oil 1/2 dog bots pills the [medxxxx] to be sold on commission or returned when called for 16 2/3 at alloved for [xxx] agt as a [xxxx] [xxxxx] [xxx xxxxxxx] March 3rd [xxxx][xx] by quill 25 Report to L D Balfow Sept 1st 1890 12 bot liver pills 6 " " " 17 Bottles salvation out large 14 " " " small W D [xxeenanay] July 8 1889 6 Bottles salvation oil small 6 bottles pill + made one payment [Page 18] 1884 [Balfours] In [xxxx] with LD Balfour July 9 Bal on Medicine " " By Cash " " [medxxx] Aug 1889 Reed of Dr LD Balfow learthage [mx] 48 Bot Salvation oil Large sige Pr bot " 33 1/3 Small sige " " " 15 Paid & bought 30th Total Balnc 12 " 12 Bots liver Pills 12 1/2 15th " S Balfour Aug 19 [Dxxxxxr] Aug 31 By Cash Dec 1889 returned Peg Pills Jan 3d [xx] S.D. Balfour order Dec 1889 31 3 Bots Salvation oil [xxxx] for [Wxx][Lixxx] + other things not charged " Home hire Lodging [xxxxxx] Dinner + feeding 2 homes for SD Balfour + Wife and credit for smal [chaxx] Aug 1890 15 on hands [xx] Balfours medicine 20 Bts liver Pills 30 " Salvation oil large 24 " small Dec 15th 91 [xxxx] [xxxx] account [xxx] [haxxxx] Also Also [Page 19] Book Account 3 00 1 10 Stack 10 Boxes Pile 1 00 [xxchade] No 1 East of old [xxhade] commencing East of Spring branch [xxxxing] Nx South 1 york [xxnpexxx] 3 05 2 jonathan 1 34 3d Ben Davis 57 [xxchade] No.2 58 Planted E + West Beginning at lot gate 1 00 1 [Baxxxxx] 1. 05 2 Mammoth Black Twig 1 04 No 3 S.W. comes Planted N + S up + down the hill 1 [xinkles] . 88 2 [Gxxxnes] Golden . 66 3d[xxxxx] Ben Davis 1 58 Planted Spring 1893 13 Peaches 500 [Foxxxer]+ and 500 Crawford 400 Buded in tree and 50 apple trees Little field East LD Balfour Cathage [xxx] 13 Bottles salvation oil 33 1/3 13 [Baxxx] [xxxx] M.P. Griffith 12 1/2 [xxxx] 12.40 By L.D.Balfour [Page 20] 1889 E [x] [Cxthxxth] [xx] Sept 17 by yoke 5 " 19 tobbacco 25 " 20 " coffee 50 " 26 " stamps [xx] 60 " 27 " Spelling book 25 Oct 1 " [xxx] handle 20 " " " Stamp 2 " " " leather 15 2 02 Oct 3 Dr to Repets 2 00 " 4 by coffee 50 " 15 " tobbacco 25 " 15 " coffee 50 " 17 " sugar 15 " 26 " coal oil 20 1 60 Nov 3 to Rents 350 " " Baldue MP 1 90 " 4 " goods to Larkin 50 " 5 " crackers 5 " 11 " tobbacco 15 " " " coffee 50 " 18 " Balance on floor 5 " 22 " coal oil 20 " 23 " nails 5 " 26 " coffee 50 " 29 " tobbacco 25 2 25 Dec 3 to Rents 3.50[190 written below 3.50 on same line] 5.40[225 written below 5.40 on same line] 3 15 3 Bal due M.P. 3 15 Settled [Page 21] E. G. Griffith cr Dec 5 by nails 10 " H door La Tohes 40 " 11 coal ail 20 " 14 Nails 33 " 18 5 " 19 Boards 75 " 20 coffee 50 " 22 one hat 40 " 24 salt 95 " 25 [frinto] 45 [xxxx] 60 " 29 flour 55 " coffee 50 Jan 2 coal aid 20 " 3 crackers 5 608 " 3 to Rents 350 315-258 258 Jan 3 Baldue M P 5-7 " 4 coferas 5 Tol 15 20 " " good to reeves girl 65 " 10 Svgar 6 Cks 5 10 " " Shirting 30 Towel 10 40 " " ging haws 20 " 17 coffee 25 " 1st Stamps 1 00 " 21 tol 10 " 22 coffee 50 " 27 Haper 5 Feb 3 3 45 cred by Pieutn 3 50 350 57 407 345 62 " " Baldive M.P. 67 " " Settled in Full [Page 22] Rental 1889 Oct 1st R W JWen [Commcsed] 1 50 28 Nov .. .. owens removed out 1890 Jany 9th Shans rent To Feb 9th E G GutGrsnth 1 50 By J M Donald Dr Feb 1890 9th Jo Mch 27th omitting day of enlesing 2 25 & leaving 1890 April 1st Dr &. B. Bnrros a 1 50 May 1st 1 50 June 1st 1 50 Read by [eaxx] 1.00 Treatment 450 July 7th Read By each 1.00JasRodencommenedNov1887280July189014JasRemoved15RM[HaxxxxMovedinAug1st7.BBunosDr20[xxxx]todate150164boys2hourslabor75Byeach2.00Bywork75DoRents7.507.52751.00 Jas Roden commened Nov 1887 280 July 1890 14 Jas Removed 15 R M [Haxxxx' Moved in Aug 1st 7.B Bunos Dr 20 [xxxx] to date 1 50 16 4 boys 2 hours labor 75 By each 2.00 By work 75 Do Rents 7.50 7.5 275 4.75 Treatment 4.50 2.5 1890 Dept 3rd Settled to date Dne G paid 25 JB [Bxxxxx] MP [xxxxxxxx] [Page 23] 1889 Nov 3rd J.B M Donald settled 1889 all bills & accounts np Jany 3rd settled mp to Feb 3rd for all rents 2 50 Balance due MP Paid oo Jul 3 settled shop bill & rents up to Mch 3 2 50 1890 April 3d shop bill up to date 1 70 all shop work and all hours rents settled To May 3d 1890 melndsing Mch & april settled to may 3rd Total 85.00 Due [xxxxxx] May 20 Reed of M Donald each 25 all smit work 85 M Donald a 1. 10 June 1890 Rents settled 2. 50 me [xxxxxx] 1. 40 July 1890 3d Shop bill to date 1. 85 Rents up to august 3d Griffith Dr for pelrod 1. 50 & sittled all rents up to Sept 1890 3d all aeets settled up to July 3d 1890 Due 75 Garried from page 7. Bill shop repairs Glrbbo and [xxxx] 3.25 Rafters & [xxxxxx] 2.80 Friday to and 1000 & 25 for ballniy 2. 75 Nails [xxxxxxx] 1. 75 W D Griffith balling 30 1.0 80 [The following section is written vertically in the bottom left corner] Axxted up to Sept 3d + due on shop bills 15cts billed xxx Griffith 135 on rent to Oct 3d 90 [Page 24] 12 20 1889 R 8 [Bwrnitl] Dr 1 75 Jan 8th [Or] D {Jeriffith] Dr 1 Bottle oil 25 Dec 21 W.D. Griffith large oil 50 [jj] griffith 1 [Bxx] oil 50 S B Raney Bot Pills 20 W D Griffith 2 Botls saluation oil 50 Went to [Bailies] 4" Jany 1890 Returned home from Bailies Saturday 18" day of Jany A D 1890 O A Griffith commenced [xxeling] The maid Jany 13 Monday rode down Creek 90 " 14 Went to Lenova 90 " 15 Down the Creek 90 Friday 17 Down the Creek 90 Sat Sunday 2 trips [Chined 25 paid Due 1 Jany 20 Down to the Creek Mail 90 June 29 [Verover] 50 50 W 22 Down THe Creek Mail 90 Friday 24 " " " 90 1890 27 " " " 90 Wednesday 29 " " " 90 Friday 31 " " " 90 25 its out May 10 down creek by 99 O 50 " 10 or by cg 75 its by qnill cash Paid Simled with JJ for the 50th With [qnill] apple trees 50 June Reed of Pa Moolk 4 Reed 1 H MS [griffin] am 15 RU a 35 5 25 Red of P [Axxxx] 4 00 [Page 25] Shoal Creek Barry Co mo Dec 23 1889 7th a greement by and [leteveen] Ruffers Aoverton elamant eniel M P Griffith representation as a greed by the malesngneed I Rufss Howerton will give figgy Per cent to The said Griffith and the attorney in Pwre ention DG and all expense Paid by them and nothing of loot Rerles Howerton 87 88 89 90 91 July 1886 26 C J Griffith left home. " Aug 20th 1890 o a Griffith Left home Chao. J. Griffith come HOme Dec 16th 1891 O.A. Griffith Come Home Dec" 23rd 1891 61 25 86 [Page 26] E C Culburth cr Feb 4 by coffee 50 " 18 " coffee 50 " 22 " one for shoes 35 " 23 " tobacco 10 " 28 " coal oil 20 ' Balon Shops of Soee 50 Mar 3 Creed by [xxxx] 3 15 " Cred by Bent 2 00 Boil Due E C S 1 15 7 Nails 15 9 tol 5 10 coffee 50 candy 3 53 18 Rope 5 21 one Bot 10 27 Balaneson shoes 35 29 Nails 20 Tol 10 30 30 coffee 50 318 Apr 2 to cash 35 3 to Rents 283/200 Baldve [xxxxxx] 83 4 Tol 10 9 Coffee 50 14 svgor Riel 25 17 Tol 5 11 to mse of Horse 1 73/25 18 rope 1 48/20 19 coffee 50 22 to cash 218/25 26 by coal ail 193/20 29 Stamps 10 May 2 one shovel plow 30 253 by rent 200 Bldve E C C 53 [Page 27] 1890 Mch 18 Delivered to D C Walker 56 apple trees 2 6 A Dyer " " 2 60 selveiter Wood Moh 12 Delivered W D Griffith Apple Trees 7" S Jeots Apple Trees D Walker " Moh 9th Old white cove [foned] dead by J Hall north a small sigs Tree felt on neok Was [xxx]& fed sunday Mch 6 Hundred by quill [Xxrday] Mch 8th & J hunted one day and on the eleventh saturday quill Mas Everything the cove when Hall informed him Moh 12 Reel of BR Brown 9 2 et Stamps 18th [Jnay] 39 Roght of H C Dnmnit 1 Wagon Rieed 1 16 00 & due 5 months from date June 21 Ried of Ed [xxxxxxx] 10 & P 25 for Bot sal oil [Page 28] James Roden Joil 14 Commemed a 1 50 Halling July 1890 14 Removed April 21 By east to J Roden 30 22 on elaim 30 ets 00 [xxxxx] oil 50 25 May 22 Red 10 Its in stamps by 2 June 6 Work by Jas & Naney Roden Bill & Ligs 75 9 Jas Roden to each 25 Bal [xxx] on [xents] 50 July 1st Jas Roden aeet Agst 1890 11 Work by Jas Roden Zo Ligs & Son 2 85 Junly 3 Per Hasness 5 00 50 [xx] slot Griffith Dr 56 25 [xxxx] Do 60 Work by Bild 6 days 9 1/2 a 40 ets Per day 2 60 Jas Roden removed Dr 1 1/2 a eve land 1 25 [Page 29] E. C. Culburth 1890 May 5 By Aocount By Ford 50 " " " coffee 50 " 10 " one for Pants 1 50 " " " " shirt 60 " 12 " tol 10 " 19 " coffee 50 " " " Rafe 10 " 21 " tol 10 " 26 " sail 5 " 27 " Bal on corn 50 " 29 " Tol 10 " 31 " coffee 50 5 08 Jun3 3 to Rent 2 00 Bal [xxx] E G 3 08 " " by Nails 20 May 31 " 1 By shoes 90 June 7 " 1 hat 25 " 9 5 Balts 13 " 11 " 2 Shovel plown 50 " " " 2 plow handles 30 " " " coffee 50 " " "1 shovel plow 40 " 16 " 5 Bolts 13 " 19 " tobbacoo 10 " " " sigar 15 " 20 " coffee 50 " 21 coal oil 20 July 2 " 1 wash Board 15 749 3 to rent 200 Baldue Ego 550 " 10 cred by casts 559 000 [Page 30] 890 hy 2 WS SevN Dr Wagon Bed 1.50 35 Peach Trees 70 5 apple Trees 25 Total 2 45 8 Dr. Pelrved 3'14 acres 1 50 Paid by McDonald July 23 93 Busheh Wheat 3 75 Cash Paid 2 00 July 165 Paid 1 75 GW Bemett Dr 2 Lu Wheat Owen Mills Dr Do Frank Jauksm 2 Bushells Paid 6 Dyer 4 Bushels wheat July 25 Jim Glask 1. 1/9 wheat W D Griffith 3 Bushells wheat 31 Eduiards 1 1/2 Bu wheat J Bennett 2 Bu wheat Mc Neely 2 sark G Burmnett 1 Bot salvation out large 50 Oct 7 & 1 Bu Wheat 85 Aug 21 Reed A 7: Jakson 1 75 on the JJ Griffith acot Sept 12 W D Griffith Dr 20 Out lot salout 50 Oct 8 S Scott delievered 1174 Boards [Page 31] Sept 22nd 90 Recud of L G&M P Griffith Sunday Lodging 1.50 ou The fast lot of pills fight by LF [Allxxxx] [xxx] Dr. Wood Jake Reiglen Bal [xxx] on same soe Agt W L Martin note ang 22 1889 13.50 Ngned [Pxxx[ Allovok Paid 7.11 [xxxx] 91 5 Jany 891 28th JJ Griffith note l. S Saml may&Aug 1891 25&30 Sept 16 1891 Lease coulrast by& [xxxxxxxx] [allsut] Johnson& J W Shepherd HR Keith agt Agent for L. Ge. Lines april 9th 9 amonths 1891 War Hontor Mote 35.00 2nd note 12 months 35.00 May 16 Paid J.M Martant 21 50 on Po Boid and 1 Bull Sealf Bosuled april 21 1896 and [xxxxx] Sot [XX] [Page 32] 1890 E. Culburth cr July 5 By Tol 20 coffee 50 7 and Book 25 16 coffee 50 18 sheeting 50 Balon Lye 5 Balon Broom 15 22 Sugar 25 Spoons 13 Knives & Forks 50 1/2 Set cups&[xxx]25 one Baker 10 to cash 20C 3 38-20 24 By coffee 3 18 25 Tol 50/10 27 Shaviug Soap 10 28 Starch 10 29 sheeting 83 30 Tol 10 31 By cash 5. 491-5 Aug 1 to 486 Tea 10 Nappie 10 20 Oil Cloth 75 Rice 10 Oil 20 2 1 pr shoes 1 35 1 well Bucket 40 coffee 50 836 3 to Rent 200 Baldng Ell 635 5ByCash 5 By Cash 1.05 355 16 50 281 Sept 3 Rent 200 Due EC 3.55 [Page 33] Oct 3 Account Ford 281 to Rent 200 By cash 81 81 Settled to Date 28 Bal on plow [xxx] 15 Tol 10 Nov 25 3 to Rent 200 Bal due M.P. 175 21 By Coffee 75 22 tol 10 25 Dnk 5 [xxx] 1 tol 5 95 3 to Rent 80 Due M P 200/280 Coffee 50 5 Salt 40 Tol 10 50 13 Tol 10 15 Nails 35 Oil 20 16 Coffee 50 20 Nails 10 25 Coffee 30 20 Coffee 25 280 Jan 3 to Rent Due Mp 200 M P And L g Griffith Chicken nerves [xxxxxx] Nora L A Griffith [xxx] JJ PG UD GL [Page 34] 1890 J.B. McDonald

    Advancing knowledge of factors affecting the personalisation of airway clearance in bronchiectasis

    No full text
    Bronchiectasis is a chronic and progressive lung disease associated with cough, sputum, and respiratory infection. The increasing burden on healthcare systems has led to renewed interest in clinical trials and developing therapies for this patient population. Airway clearance techniques (ACTs) are recommended as an integral part of management to facilitate secretion removal, improve symptoms and health-related quality of life (HRQOL). Guidelines recommend that ACTs should be personalised to improve outcomes. Our understanding about ACTs in bronchiectasis however remains limited. Currently there are no definitive guidelines on the optimal prescription of ACTs. Personalised prescription appears to be dependent upon clinical expertise, local training, and workplace culture. Significant knowledge gaps exist in literature regarding optimisation of ACTs for individuals with bronchiectasis. The overarching aim of this thesis was to enhance the personalised prescription of ACTs in bronchiectasis. Four studies were completed. The first study commenced at the airway clearance device itself and the properties of different commonly prescribed devices. The second study summarised outcome measures used in ACT studies and the final two studies examined separately the patient and physiotherapist perspectives of ACTs. Positive expiratory pressure (PEP) devices are a type of ACT device widely used in clinical settings. The comparative performance characteristics of these devices remain unknown. Study One (Chapter Three) was an experimental bench study which compared the performance characteristics (mean PEP, peak PEP, amplitude PEP and oscillation frequency) of six different PEP devices by varying resistance and flow. Results showed the performance characteristics of the devices differed across flows and resistance settings. Some commonly used devices (e.g. Acapella Choice, Acapella DH, Aerobika and Pari PEP S) were flow-dependent, whilst the performance characteristics of other devices (e.g. Acapella DM and Flutter) were independent of flow. Varying flow or resistance typically maintained or increased the production of mean, peak, and amplitude PEP and oscillation frequency. The clinical implications of the small but significant differences in performance characteristics of these PEP devices requires further investigation. Whilst ACTs are recommended for individuals with bronchiectasis, many trials have demonstrated inconsistent benefits or failed to reach their primary outcome. The narrative review of Study Two (Chapter Four) documented the most common clinical and patient-related outcome measures used to evaluate the efficacy of ACTs in bronchiectasis. The review included 27 published studies and 1 abstract. The most common clinical outcome measures were sputum volume (n = 23), lung function (n = 17) and pulse oximetry (n = 9). The most common patient-related outcomes were HRQOL (St George Respiratory Questionnaire, n = 4), cough-related quality of life (QOL) (Leicester Cough Questionnaire, n = 4) and dyspnoea (Borg / modified Borg scale, n = 8). This review highlighted the large heterogeneity in outcome measures used in ACT trials to date and recommended guidance on standardising the most important clinical and patient-related outcome measures for this patient population. With standardised outcome measures in place, the efficacy of different interventions can be compared leading to improved personalisation of ACTs in bronchiectasis. Even though ACTs are recommended in bronchiectasis, data suggests the use of and adherence to ACTs is poor. Study Three (Chapter Five) identified patient perceptions regarding ACTs, the barriers and facilitators of ACTs, and factors affecting adherence. A multi-centre qualitative study using in-depth semi-structured interviews of 24 individuals with bronchiectasis was undertaken. The main facilitators of using ACTs included a perceived health and QOL benefit, a tailored approach to ACTs and the use of self-management strategies. Main barriers to ACTs included lack of time and motivation, a lack of access to resources and, surprisingly, a lack of perceived health benefit. Several suggestions were also made that may help promote adherence including combining and trialling different ACTs, receiving regular ACT reviews and education from physiotherapists, and having good social support. Taking another perspective, Study Four (Chapter Six) examined physiotherapist perceptions of ACTs in both inpatients and outpatients with bronchiectasis. This was a single-centre qualitative study that used in-depth semi-structured interviews with eleven physiotherapists who treated individuals with bronchiectasis. The study revealed that physiotherapists regularly and routinely prescribe ACTs for inpatients and outpatients with bronchiectasis, however the clinical decision-making regarding optimal ACT prescription was regarded as complex. Main themes influencing ACT prescription included organisational factors (workload, scope of service, access to resources / ACTs, financial burden of ACT); patient-related factors (symptom severity, finances, disease-specific knowledge, social commitments, timing of ACT, clinical setting, perceived benefit, and motivation); and physiotherapist / profession-related factors (clinical experience, access to professional support and education, awareness of evidence of ACTs and evaluating ACT effectiveness). In summary, the work presented in this thesis serves to refine the prescription of ACTs for bronchiectasis. There are different ACT devices prescribed by clinicians that have different performance characteristics. Due consideration of these performance characteristics needs to be given when prescribing ACTs. The marked heterogeneity of study designs and outcome measures used to evaluate ACTs in bronchiectasis has made the interpretation of different ACT intervention studies difficult. There is a need for standardisation of outcome measures for ACTs that will enable future intervention studies to be more comparable. Individuals with bronchiectasis and physiotherapists prescribing ACTs describe multiple factors that may impact upon adherence to ACTs. For patients, these barriers and facilitators centre on improving HRQOL. For the prescribing physiotherapist, airway clearance centres on the complexity of the patient and intervention. The results from the four studies in this doctoral program should be considered by physiotherapists to assist the personalised prescription of ACTs with the ultimate outcome of improving adherence and HRQOL for individuals with bronchiectasis.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)School of Health Sci & Soc WrkGriffith HealthFull Tex
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