540 research outputs found
Blind Polarization Demultiplexing of Probabilistically Shaped Signals
No full textWe propose a novel method for blind polarization-demultiplexing of probabilistically shaped signals for coherent receivers. The method is capable of separating signals with (quasi) Gaussian distributions by exploiting temporal correlations added to the transmit signals. The proposed method is evaluated in challenging mixing scenarios.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Sander WahlsTeam Raf Van de Pla
Fault estimation filter design with guaranteed stability using Markov parameters
No full textAccepted Author ManuscriptTeam Tamas KeviczkyTeam Raf Van de Pla
Physical and Computational Approaches to Aberration Correction In Fluorescence Microscopy
No full textThe goal of this thesis, called Physical and Computational Approaches to Aberration Correction In Fluorescence Microscopy, concerns itself with the development of new techniques to control adaptive fluorescence microscopes, so that they can adapt and image with increased resolution, contrast and speed inside complex three-dimensional biological samples.Team Raf Van de Pla
Aliasing, coherence, and resolution in a lensless holographic microscope
No full textAccepted Author ManuscriptTeam Raf Van de Pla
Activation of Grm1 expression by inducible mutated B-RAF in vitro and in vivo
No full textMelanoma is a form of skin cancer that arises from the neoplastic transformation of melanocytes. Constitutive activation of the MAPK pathway due to mutations in the serine-threonine protein kinase B-RAF or N-RAS has been reported to play important roles in melanomagenesis. Previously, our laboratory identified that ectopic expression of metabotropic glutamate receptor 1 (Grm1) in melanocytes was sufficient to induce spontaneous melanoma development in transgenic mouse models (TG-3 and EPv). We also demonstrated that Grm1 expression activates the MAPK pathway. Recently, we detected Grm1 expression by immunohistochemical staining of tumors derived from transgenic mice harboring a B-RAF (V600E) mutation on PTEN null background. Similarly, Grm1 expression was also detected in tumor samples derived from transgenic mice with an N-RAS (Q61R) mutation on INK4a null background. In addition, several stable immortalized mouse melanocytic clones with exogenous mutant B-RAF (V600E) cDNA showed Grm1 expression in vitro. Since normal mouse melanocytes acquire loss of p16INK4a in order to become immortalized, we investigate whether loss of PTEN or INK4a/ARF was required for Grm1 expression by mutated B-RAF (V600E). We made use of a transgenic mouse model (BJB), which has an inducible B-RAF (V600E) genotype only in melanocytes. Here we show that induction of B-RAF (V600E) stimulates skin hyperpigmentation, presumably from increased proliferation of melanocytes. Results showed detectable Grm1 expression in BJB skin samples, suggesting that the induction of mutated B-RAF (V600E) may be sufficient to promote activation of Grm1 expression, and that ablation of PTEN expression/function but not of INK4a may be required.M.S.Includes bibliographical referencesby Jairo L. Sierr
RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
No full textNRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers, raising the question of the role of RAF proteins in NRAS-induced melanoma. Here, using conditional ablation of Raf genes in NRAS-induced mouse melanoma models, we investigate their contribution in tumour progression, from the onset of benign tumours to malignant tumour maintenance. We show that BRAF expression is required for ERK activation and nevi development, demonstrating a critical role in the early stages of NRAS-driven melanoma. After melanoma formation, single Braf or Craf ablation is not sufficient to block tumour growth, showing redundant functions for RAF kinases. Finally, proliferation of resistant cells emerging in the absence of BRAF and CRAF remains dependent on ARAF-mediated ERK activation. These results reveal specific and compensatory functions for BRAF and CRAF and highlight an addiction to RAF signalling in NRAS-driven melanoma.© The Author(s) 201
In Every Place: The RAF Armoured Cars in the Middle East 1921-1953
No full textThis book is a fascinating and compelling account of over 30 years of distinguished service of the Royal Air Force Armoured Cars from Iraq, Jordan, Palestine and Aden, to North Africa.
Formed in the early 1920s as a key component of the RAF Scheme of Air Control, they supported the League of Nations Mandates in Palestine and Iraq following the Great War. Air control, based on the use of aircraft, armoured cars and locally-recruited levies, was an effective and efficient means of policing and controlling the tribes and townspeople of these territories.
The work of the RAF Armoured Car Companies, which became Squadrons of the RAF Regiment in 1946, was many and varied; patrolling the mountains and deserts, protecting RAF airfields and convoys, "showing the flag", escorting VIPs and coordinating air and ground operations. They were called in on numerous occasions to suppress troubles from ethnic and tribal groups, and to contain rebellions and invasions while working in close cooperation with the flying squadrons of the RAF.
One of their greatest contributions was made early in the Second World War when Nos 1 and 2 Companies both played a major role in preventing Iraq and Syria falling into the hands of the Axis forces.
This book draws on RAF official records at the National Archives of the United Kingdom, the personal diaries, letters, and reminiscences held at the Imperial War Museum, RAF Museum Hendon, and RAF Regiment Museum and by the RAF Armoured Cars Association, as well as the author's interviews with the officers and airmen who served in the RAF Armoured Cars.
The author presents the story not only in the political, strategic and tactical context of operations, but also gives the view from the turret and driver's seat of the car commanders, gunners, wireless operators and fitters
RAF High Command in the Second World War – A New Perspective
No full textThis was intended to be the first in a series of three articles examining the development of the RAF High Command during the Second World War; unfortunately, due to illness only the first article was completed. Reproduced here the article covers the period from 1932 until the outbreak of war in 1939, shedding new light on the re-organisations of the Air Ministry in 1934, the RAF Command structure in 1936, and the tri-service debate in 1937 concerning the RAF proposal to establish a Supreme Air Commander. It challenges the established historiography casting a different perspective on RAF reforms, and as such offers a fresh starting point for analysing the RAF’s High Command structure and organisation as the Second World War approached. The subsequent two articles were intended to assess the development of RAF High Command practice as the war unfolded and operational challenges were met. Nonetheless, as is characteristic of the author it presents a challenging contribution to the history of the RAF as wartime approached
Discrete Darboux based fast inverse nonlinear Fourier transform algorithm for multi-solitons
No full textA fast algorithm for constructing multi-solitons with linear complexity in the number of samples and eigenvalues is introduced. The algorithm is shown to be significantly faster than the conventional Darboux transform in a numerical example, with acceptable error.Accepted Author ManuscriptTeam Raf Van de PlasTeam Sander Wahl
Nonlinear Fourier transform algorithm using a higher order exponential integrator
No full textWe present a nonlinear Fourier transform algorithm whose accuracy, at a comparable runtime and for moderate step sizes, is orders of magnitude better than that of the classical Boffetta-Osborne method.Accepted Author ManuscriptTeam Sander WahlsTeam Raf Van de Pla
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