357 research outputs found
Nothing or next to nothing (Atlantic City blues)
No full textNothing or Next to Nothing (Atlantic City Blues) is a novella steeped in the tradition of American Naturalism. It follows the lives of teenage brother and sister, Derek and Daisy Kehoe, after the death of their mother and abandonment by their father.M.F.A.by Barry GrahamIncludes abstrac
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The twelve large colour prints of William Blake: a study on techniques, materials and context
No full textThe aim of this thesis is to study in entirety the group of large colour prints which William Blake made between 1795 and 1805. The series of prints represents the single most important and complete development of Blake’s skill as an innovative printmaker. Although they include some of Blake’s best-known images, they have not been studied before in their entirety or from the point of view of analysing the techniques and methods Blake had used. My study will show how Blake executed these truly impressive prints in terms of materials, method and motives. The first half of the thesis deals with the materialistic aspects of Blake’s colour printing. In chapter one tracing the controversial two-pull discussion to the root, I will make clear the focus points as well as revealing the early tradition of experimental criticism on Blake’s colour printing method. Focusing on two important critics, W. Graham Robertson and Ruthven Todd, and the periods they lived, I attempt to reveal the role they played in a wider context. Also I show how the tradition of Blake’s art was inherited directly through the Ancients to the Pre-Raphaelite Brotherhood, which leads to Robertson and Todd. In the second chapter I deal with the development of Blake’s colour printing experiments. It is obvious that the Twelve Large Colour Prints were produced as a result of Blake’s series of colour printing experiments, starting with monocolour simple prints, going through the illuminated books progressing with more colours and higher skills
Mean Annual Temperature and Total Annual Precipitation Trends at Canadian Biosphere Reserves
No full textThis article examines instrumental climate records from a variety of stations associated with the following Biosphere Reserves across Canada: (i) Waterton Lakes, (ii) Riding Mountain, (iii) Niagara Escarpment, (iv) Long Point, and (v) Kejimkujik (Candidate Biosphere Reserve). Annual series are generated from daily temperature and precipitation values. In addition, homogeneous data are used from other stations and regional records to supplement the records from the local biosphere stations. Long term trends are identified over the period of the instrumental record. In general, data from the interval 1900 to 1998 show cooler temperatures in the 1920's, warming from the early 1940's into the early 1950's, cooling into the 1970's, and subsequent warming. At many stations, 1998 is the warmest in the instrumental record. Comparisons with the regional data sets show good agreements between the temperature series. The 20th century warming is approximately 1.0 °C in the Riding Mountain area and 0.6 °C in the Long Point, Niagara Escarpment, and Waterton Lakes areas. There has been slight cooling in the Kejimkujik area over the past half century. Precipitation data show increasing trends in the Kejimkujik, Long Point, Niagara Escarpment, and Waterton Lakes areas with no long term trend in the Riding Mountain area. This work is part of the Canadian Biosphere Reserves Association (CBRA) Climate Change Initiative (CCI), designed to present climate change information to Biosphere Reserve communities to allow local organizations to understand climate change and adapt to potential impacts. ABSTRACT FROM AUTHOR]; Copyright of Environmental Monitoring & Assessment is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)M3: ArticleSource type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=8gh&AN=16655924&site=eds-live&scope=sit
Early pregnancy weight gain and fat accrual predict pregnancy outcome in growing adolescent sheep
No full textFunding: This work was funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division. Author contribution statement: JW developed the animal model, performed experiments, analysed the data and wrote the paper. RA and JM performed experiments and conducted the laboratory analysis. Acknowledgements: Dr Graham Horgan (Biomathematics and Statistics Scotland) provided statistical advice and Dr Clare Adam gifted the leptin antibody.Peer reviewe
A Simple Cell-Based Assay for the Detection of Surface Protein Shedding by Rhomboid Proteases
No full textRhomboids are intramembrane serine proteases that cleave their substrates within or immediately adjacent to their transmembrane domains, a process known as regulated intramembrane proteolysis. In eukaryotes, two main types of rhomboid proteases can be distinguished based on their subcellular localization: mitochondrial rhomboids and secretase-type rhomboids that target the secretory pathway. The latter class can cleave and release the extracellular domain of all epidermal growth factor-like proteins in Drosophila and can liberate epidermal growth factor (EGF) in mammals, in a process known as ectodomain shedding. These released EGFs can then activate the EGF receptor (EGFR). EGFR signaling is crucial for mammalian development and is often deregulated in human cancer. Here we describe a cell-based protocol for detecting the ability of rhomboid proteases to release EGFR ligands into the medium. First, cells are transfected with the corresponding protease- and substrate-expressing vectors; second, cells condition the medium and accumulate shed protein. After this, protein lysates from cells and media are prepared and Western blotting is performed to detect the EGFR ligands that have been released into the medium.</p
Sink or swim: Examining the current impacts & future challenges of publicly funded swimming venues in Prince Edward Island
No full textSwimming has deep-roots on Prince Edward Island. Through examining secondary data
from a variety of sources including swim clubs, pool owners and operators, provincial sport
organizations, and national sport organizations the intentions for this study is to determine what
impacts publicly funding swimming pools have on Prince Edward Island. With public tax dollars
being contributed to the operations of these facilities, the facilities are often subject to scrutiny of
the return on investments through the eyes of the tax payers. By compiling, analyzing, and
describing the data obtained in this study, the researcher hopes that the impact these facilities make
on Prince Edward Island will be clearer for all those interested parties. Through the analysis of
longitudinal data, trends pertaining to participation in swimming sports, employment
opportunities, and the number certified potential employees will be described. Key learning
outcomes from the study will be available as well as recommendations to address these outcomes
and trends within the industry
Carboxylation of carbenes in low-temperature matrixes
No full textPT: J; CR: ADAM W, 1971, J AM CHEM SOC, V93, P557 ADAM W, 1973, J ORG CHEM, V38, P2269 BAMFORD WR, 1952, J CHEM SOC, P4735 BONNEAU R, 1989, J CHEM SOC CHEM COMM, P510 CHAMPAM OL, 1972, J AM CHEM SOC, V94, P1365 COE PL, 1982, J CHEM SOC CHEM COMM, P362 EISENTHAL KB, 1985, TETRAHEDRON, V41, P1543 GANZER GA, 1986, J AM CHEM SOC, V108, P1517 GOULD IR, 1985, TETRAHEDRON, V41, P1587 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, 1985, TETRAHEDRON, V41, P1525 LIU MTH, 1980, J CHEM SOC CHEM COMM, P1482 LIU MTH, 1987, TETRAHEDRON LETT, V28, P1011 MALTSEV AK, 1985, IAN SSSR KH, P2159 MCMAHON RJ, 1987, J AM CHEM SOC, V109, P2456 MILLIGAN DE, 1962, J CHEM PHYS, V35, P2911 MOSS RA, 1989, ACCOUNTS CHEM RES, V22, P15 PLATZ MS, 1990, KINETICS SPECTROSCOP, P239 PUZA M, 1971, SYNTHESIS-STUTTGART, P481 SANDER W, 1988, ANGEW CHEM INT EDIT, V27, P572 SANDER W, 1988, ANGEW CHEM, V100, P577 SANDER W, 1988, J ORG CHEM, V53, P2091 SANDER W, 1990, ANGEW CHEM INT EDIT, V29, P344 SANDER W, 1990, ANGEW CHEM, V102, P362 SANDER WW, 1987, SPECTROCHIM ACTA A, V43, P637 SANDER WW, 1989, J ORG CHEM, V54, P333 SANDER WW, 1989, J ORG CHEM, V54, P4265 SIEBRAND W, 1986, ACCOUNTS CHEM RES, V19, P238 WHELAND R, 1970, J AM CHEM SOC, V92, P6057; NR: 29; TC: 22; J9: J ORG CHEM; PG: 3; GA: HB875Source type: Electronic(1
Author response: Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
No full textProteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ligands of the epidermal growth factor receptor. iRhoms, catalytically inactive members of the rhomboid-like superfamily, have been shown to control the ER-to-Golgi transport and maturation of TACE. Here, we reveal that iRhom2 remains associated with TACE throughout the secretory pathway, and is stabilised at the cell surface by this interaction. At the plasma membrane, ERK1/2-mediated phosphorylation and 14-3-3 protein binding of the cytoplasmic amino-terminus of iRhom2 alter its interaction with mature TACE, thereby licensing its proteolytic activity. We show that this molecular mechanism is responsible for triggering inflammatory responses in primary mouse macrophages. Overall, iRhom2 binds to TACE throughout its lifecycle, implying that iRhom2 is a primary regulator of stimulated cytokine and growth factor signalling
Williama Goldinga Siłą bezwładu w perspektywie ontologii zorientowanej na przedmiot
No full textThe paper applies selected devices of the methodology of Object-Oriented Ontology to study William Golding’s novel Free Fall. Particular attention is given to Graham Harman’s project, whose definition of an object accounts for all beings, humans included. Within the ontological structure of an object two components can be distinguished: the “sensual object”, which can engage in relationships with other objects, and the “real object”, which refrains from any connections. The author aims to show how the main protagonist of Golding’s novel is impacted on by material objects, how other humans are perceived by him as inherently dual beings, but most importantly how the protagonist himself discovers the thing-like quality of his own human condition.The paper applies selected devices of the methodology of Object-Oriented Ontology to study William Golding’s novel Free Fall. Particular attention is given to Graham Harman’s project, whose definition of an object accounts for all beings, humans included. Within the ontological structure of an object two components can be distinguished: the “sensual object”, which can engage in relationships with other objects, and the “real object”, which refrains from any connections. The author aims to show how the main protagonist of Golding’s novel is impacted on by material objects, how other humans are perceived by him as inherently dual beings, but most importantly how the protagonist himself discovers the thing-like quality of his own human condition
Inclusive Interconnections: Towards Open-Ended Parameter-Sharing for Laptop Ensemble
No full textThis research project concerns the use of networks in laptop performance, which allow
players to directly shape the musical voices of their peers. The author’s recent work with the
Huddersfield Experimental Laptop Orchestra has highlighted a need to develop player-‐
centred networks, in order to foster a wider exploration of interdependent approaches to
musical performance. The core of this thesis details the design of a parameter-‐sharing
system which aims to support a diverse set of approaches to performance, whilst allowing
interdependencies to be flexibly reconfigured by players. The resulting system has been
tested and evaluated with a cross-‐section of experienced laptop performers, with initial
results showing that the system enables players to bring their existing experience to
interdependent performance. In addition, the use of a high-‐level graphical model for
manipulating interconnections allows a range of interdependencies to be explored at
performer-‐level. Future work aims to support a broader range of performance practice and
make the process of manipulating interconnections more intuitive
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