3,250 research outputs found
Genomic RDA for the identification of chromosomal aberrations in pancreatic cancer: merits and in drawbacks
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Endoskopische Diagnostik von Helicobacter pylori: Die klinische Herausforderung von suppressiven Bedingungen
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Molecular pathways implicated in pancreatic ductal cancer are not involved in exocrine nonductal or endocrine tumorigenesis
No full textThe description of the molecular pathways implicated in pancreatic ductal carcinomas
Genome-wide allelotyping of pancreatic acinar cell and non-functional endocrine tumors
No full textGenome-wide allelotyping of pancreatic acinar cell permitted the molecular differential diagnosis with non-functional endocrine tumor
Chromosomal imbalances in pancreatic tumors detected by arbitrarily primed PCR fingerprinting
No full textThe study revealed a chromosomal imbalances of pancreatic tumors, using arbitrarily primed PCR fingerprintin
Loss of the Y chromosome is one of the most frequent chromosomal imbalances in pancreatic cancer
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Differentiation of multiple types of pancreatico-biliary tumors by molecular analysis of clinical specimens
No full textTimely and accurate diagnosis of pancreatic ductal adenocarcinoma (PDAC)
is critical in order to provide adequate treatment to patients. However,
the clinical signs and symptoms of PDAC are shared by several types of
malignant or benign tumors which may be difficult to differentiate from
PDAC with conventional diagnostic procedures. Among others, these
include ampullary cancers, solid pseudopapillary tumors, and
adenocarcinomas of the distant bile duct, as well as inflammatory masses
developing in chronic pancreatitis. Here, we report an approach to
accurately differentiate between these different types of pancreatic
masses based on molecular analysis of biopsy material. A total of 156
bulk tissue and fine needle aspiration biopsy samples were analyzed
using a dedicated diagnostic cDNA array and a composite classification
algorithm developed based on linear support vector machines. All five
histological subtypes of pancreatic masses were clearly separable with
100\% accuracy when using all 156 individual samples for classification.
Generalized performance of the classification system was tested by
10x10-fold cross validation (100 test runs). Correct classification into
the five diagnostic groups was demonstrated for 81.5\% of 1,560 test set
predictions. Performance increased to 85.3\% accuracy when PDAC and
distant bile duct carcinomas were combined in a single diagnostic class.
Importantly, overall sensitivity of detection of malignant disease was
92.2\%. The molecular diagnostic approach presented here is suitable to
significantly aid in the differential diagnosis of undetermined
pancreatic masses. To our knowledge, this is the first study reporting
accurate differentiation between several types of pancreatico-biliary
tumors in a single molecular analytical procedure
Synthesis optimization and charge carrier transfer mechanism in LiLuSiO<sub>4</sub>:Ce, Tm storage phosphor
No full textLiLuSiO4:Ce and LiLuSiO4:Ce, Tm show very efficient charge carrier storage properties upon beta irradiation after samples have received treatment in vacuum. They outperform the commercial storage phosphor BaFBr(I):Eu2+ in many aspects. The influence of the synthesis conditions, Ce and Tm concentration, nonstoichiometry and codoping with Ca, Hf, Al and Ge are reported. Based on the results of the synthesis optimization, thermoluminescence (TL) emission and TL excitation spectra a mechanism of charge carrier transfer, storage, and recombination during irradiation and thermal or optical readout is proposed.Accepted Author ManuscriptRST/Fundamental Aspects of Materials and EnergyRST/Luminescence Material
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