196,693 research outputs found
Na,K-ATPase on a waveguide sensor : supramolecular assembly and side directed binding studies by surface-confined fluorescence
No full textGrell E, Pawlak M, Anselmetti D, Schick E, Lewitzki E, Ehrat M. Na,K-ATPase on a waveguide sensor : supramolecular assembly and side directed binding studies by surface-confined fluorescence. In: Taniguchi K, Kaya S, eds. Na/K-ATPase and related ATPases: proceedings of the 9th International Conference on the Na/K-ATPase and Related ATPases. Excerpta Medica international congress series. Vol 1207. Amsterdam: Elsevier; 2000: 437-440.The functional assembly of FITC-Na,K-ATPase membrane fragments on a surface-modified Ta2O5 waveguide allows to investigate the directed binding of ligands by surface-confined fluorescence studies. The results allow to draw conclusions about the sidedness of interactions. The fluorescence intensity decrease observed upon the selective binding of K+ is attributed to its coordination to a site accessible from the former intracellular membrane side
Versatile Coordination Chemistry of Hexa- tert-butyl-octaphosphine
No full textThe octaphosphine {cyclo-(P4tBu3)}2 (1) possesses a multifaceted coordination chemistry. The predominant binding mode is a P,P-chelate, e.g., in the monometallic chelate complex [MLL′(1-κ2P2,P4′)] in which the ligand 1 adopts a gauche conformation. Examples include square-planar (M = RhI, L = CO, L′ = Cl (2), M = PdII, L = L′ = Cl (3), M = PtII, L = L′ = Cl (9)), tetrahedral (M = Co-I, L = NO, L′ = CO (4)), and trigonal-planar complexes [ML(1-κ2P2,P4′)] (M = Pd0, L = PPh3, (5), M = CuI, L = Br (6)). With 2 equiv of [CuBr(SMe2)], a dinuclear complex [(CuBr)2(1-κ2P2,P2′,κ2P4,P4′)] (7) was obtained which features a synperiplanar conformation of the octaphosphine. A second coordination mode was also observed in [PtCl2(1-κ2P1,P2′)] (10) in which the bridge phosphorus atom in octaphosphine 1 is involved in the chelation, with the ligand in an antiperiplanar conformation. Thermolysis of selected complexes showed them to be suitable candidates for the generation of phosphorus-rich metal phosphides MPx (x > 1)
Functional Immobilization of Biofragments on Planar Waveguides for the Investigation of Side-Directed Ligand Binding by Surface-Confined Fluorescence
No full textPawlak M, Grell B, Anselmetti D. Functional Immobilization of Biofragments on Planar Waveguides for the Investigation of Side-Directed Ligand Binding by Surface-Confined Fluorescence. Faraday Discussions. 1999;111:273-288
Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Matrix Metalloproteinases (MMPs) as Diagnostic/Prognostic Biomarkes of Bladder Cancer
No full textUnusual Reactivity of cyclo-(P 5 Ph 5 ) : Oxidative Addition at a Group 6 Metal Carbonyl and Insertion of Acetonitrile into a P–P Bond
No full textThe reaction of [M(CO) 4 L x ] {M = Cr, W, L = MeCN, x = 2; M = Mo, L = 2,5-norbornadiene (nbd), x = 1} with cyclo-(P 5 Ph 5 ) led to an unusual transformation reaction including the oxidative addition of a P–P bond to the Group 6 metal carbonyl, the insertion of MeCN into a P–P bond, and the formation of an M–M bond. The products were characterized by IR and 31 P{ 1 H} NMR spectroscopy, ESI mass spectrometry and single crystal X-ray crystallography. The complexes contain a metal–metal unit bridged by two terminal phosphanido groups of the novel ligand, (PPh-PPh-PPh-PPh-CMe=N-PPh) 2– . The 31 P{ 1 H} NMR spectrum shows an ABCDE spin system consistent with the molecular structure observed in the solid state. Furthermore, the thermal properties of the complexes were evaluated
Variation of Cancer Incidence between and within GRELL Countries.
No full textVariation in cancer incidence between countries and groups of countries has been well studied. However cancer incidence is linked to risk factors that may vary within countries, and may subsist in localized geographic areas. In this study we investigated between- and within-country variation in the incidence of all cancers combined for countries belonging to the Group for Cancer Epidemiology and Registration in Latin Language Countries (GRELL). We hypothesized that investigation at the micro-level (circumscribed regions and local cancer registry areas) would reveal incidence variations not evident at the macro level and allow identification of cancer incidence hotspots for research, public health, and to fight social inequalities. Data for all cancers diagnosed in 2008-2012 were extracted from Cancer Incidence in Five Continents, Vol XI. Incidence variation within a country or region was quantified as r/R, defined as the difference between the highest and lowest incidence rates for cancer registries within a country/region (r), divided by the incidence rate for the entire country/region × 100. We found that the area with the highest male incidence had an ASRw 4.3 times higher than the area with the lowest incidence. The area with the highest female incidence had an ASRw 3.3 times higher than the area with the lowest incidence. Areas with the highest male ASRws were Azores (Portugal), Florianopolis (Brazil), Metropolitan France, north Spain, Belgium, and north-west and north-east Italy. Areas with the highest female ASRws were Florianopolis (Brazil), Belgium, north-west Italy, north-east Italy, central Italy, Switzerland and Metropolitan France. Our analysis has shown that cancer incidence varies markedly across GRELL countries but also within several countries: the presence of several areas with high cancer incidence suggests the presence of area-specific risk factors that deserve further investigation
Trends in incidence of breast cancer among women under 40 in seven European countries: a GRELL cooperative study
No full textYoung women are not usually screened for breast cancer (BC). The trends in incidence in this population may better reflect changes in risk factors. However, studies on this subject are scarce and heterogeneous. The aim of this study was to describe the trends in incidence of BC in women under 40 from 1990 to 2008, using pooled European data. Thirty-seven European population-based cancer registries from Belgium, Bulgaria, France, Italy, Portugal, Spain and Switzerland participated in this study. World age-standardized incidence rates were first analyzed graphically and then using a Poisson regression model, in order to estimate average annual percent changes (AAPCs). The overall incidence rate of BC in the area covered increased linearly during the study period by 1.19% (0.93; 1.46) on average per year. This increase varied between countries from 0.20% (-0.53; 0.64) in Bulgaria to 2.68% (1.97; 3.40) in Portugal. In Italy, after a significant rise of 2.33% (1.14; 3.54) per year, BC incid...Young women are not usually screened for breast cancer (BC). The trends in incidence in this population may better reflect changes in risk factors. However, studies on this subject are scarce and heterogeneous. The aim of this study was to describe the trends in incidence of BC in women under 40 from 1990 to 2008, using pooled European data. Thirty-seven European population-based cancer registries from Belgium, Bulgaria, France, Italy, Portugal, Spain and Switzerland participated in this study. World age-standardized incidence rates were first analyzed graphically and then using a Poisson regression model, in order to estimate average annual percent changes (AAPCs). The overall incidence rate of BC in the area covered increased linearly during the study period by 1.19% (0.93; 1.46) on average per year. This increase varied between countries from 0.20% (-0.53; 0.64) in Bulgaria to 2.68% (1.97; 3.40) in Portugal. In Italy, after a significant rise of 2.33% (1.14; 3.54) per year, BC incidence began decreasing in 2002 by -2.30% (-4.07; -0.50) yearly. The rise in incidence was greater for women under 35 and for ductal carcinomas. This increase can be due to a rise in risk factors and/or changes in diagnosis and surveillance practices, but we could not clearly distinguish between these two non-exclusive explanations
The impact of PAP smear screening on cervical cancer in Italy: a national-based multicentric collaborative study.
No full textL’écriture du Je dans la langue de l’exil, dir. I. Grell-Borgomano et J.-M. Devésa
No full textCe recueil, consacré à «l’écriture translingue de soi» (Isabelle Grell-Borgomano, Introduction: Interroger «l’écriture translingue de soi»), selon la définition empruntée à Alain Ausoni (qui collabore à ces mélanges), nous confirme, si besoin en était, la complexité et en même temps la vitalité de cette écriture de l’exil, écriture en mouvement, où écriture de l’errance, du tremblement comme dirait Édouard Glissant, car souvent les écrivains concernés ne se limitent pas au passage d’un pays à..
Versatile Coordination Modes of Triphospha-1,4-pentadiene-2,4-diamine
No full text1,3,5-Triphospha-1,4-pentadiene-2,4-diamine reacts with [M(CO)4L] (M = Mo, L = nbd (norbornadiene); M = W, L = 2 CH3CN) to give the chelate complexes [M(CO)4(PMes{C(NHCy)PMes}2-κP1,P3)]. In contrast, an unusual intramolecular rearrangement occurred with [Cu(CH3CN)4]PF6 leading to the dimeric copper(I) complex [Cu(CNCy){PHMesPMesC(NHCy)PMes-κP1,P3}]2(PF6)2. The mechanism of the rearrangement was supported by quantum-mechanical calculations. The transition-metal complexes were characterized by multinuclear NMR spectroscopy, mass spectrometry, infrared spectroscopy, and X-ray crystallography
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