4,894 research outputs found

    Featuring Gregory M. Nixon’s Work with Commentaries & Responses. HOLLOWS OF MEMORY. From Individual Consciousness to Panexperientialism and Beyond

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    Table of Contents Article Preface/Introduction Gregory M. Nixon 213-215 From Panexperientialism to Conscious Experience: The Continuum of Experience Gregory M. Nixon 216-233 Hollows of Experience Gregory M. Nixon 234-288 Myth and Mind: The Origin of Human Consciousness in the Discovery of the Sacred Gregory M. Nixon 289-337 ………………………………………………………………………………………………….. Commentary Brief Comment on Gregory Nixon’s Hollows of Experience: Derrida Frederick D. Abraham 338-341 Playing With Your Food: Review of “Hollows of Experience” by Greg Nixon William A. Adams 342-345 Brief Commentary on Nixon's Three Papers Roger Cook 346-347 Commentary on Nixon's From Panexperientialism to Individual Self Consciousness Stephen Deiss 348-349 Nixon on Conscious and Non-conscious Experience Gordon Globus 350-351 Commentary on Nixon's From Panexperientialism to Individual Self Consciousness Syamala Hari 352-353 The Predictive Mind and Mortal Knowledge Marc Hersch 354-368 Consciousness as Shared and Categorized Result of Experience Tim Jarvilehto 369-371 Brief Comment on Gregory Nixon’s Myth and Mind Joseph McCard 372-372 Commentary on Nixon's Three Papers Marty Monteiro 373-376 Brief Commentary on Nixon's “From Panexperientialism to Conscious Experience” Richard W Moodey 377-378 Hollows of a Science of Consciousness? Alfredo Pereira Jr. 379-380 Comment on Gregory Nixon’s “From Panexperientialism to Individual Self Consciousness” Steven M. Rosen 381-382 Consciousness, Non-conscious Experiences and Functions, Proto-experiences and Protofunctions, and Subjective Experiences Ram L. P. Vimal 383-389 ………………………………………………………………………………………………….. Response to Commentary Response to the Commentary of Frederick D. Abraham Gregory M. Nixon 390-390 Response to the Commentary of William A. Adams Gregory M. Nixon 391-392 Response to the Commentary of Syamala Hari Gregory M. Nixon 393-394 Response to the Commentary of Marc Hersch Gregory M. Nixon 395-398 Response to the Commentary of Joseph McCard Gregory M. Nixon 399-399 Response to the Commentary of Steven M. Rosen Gregory M. Nixon 400-40

    Elaine M. Alexander: 2023 Cook Prize Gold Medal Acceptance Speech

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    Author Elaine M. Alexander gives an acceptance speech for Anglerfish: The Seadevil of the Deep, illustrated by Fiona Fogg (Candlewick)https://educate.bankstreet.edu/cook/1007/thumbnail.jp

    Going live : building academic capacity in blended learning using web-conferencing technologies

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    This paper reports on a current initiative at Queensland University of Technology to provide timely, flexible and sustainable training and support to academic staff in blended learning and associated techno-pedagogies via a web-conferencing classroom and collaboration tool, Elluminate Live!. This technology was first introduced to QUT in 2008 as part of the university‘s ongoing commitment to meeting the learning needs of diverse student cohorts. The centralised Learning Design team, in collaboration with the university‘s department of eLearning Services, was given the task of providing training and support to academic staff in the effective use of the technology for teaching and learning, as part of the team‘s ongoing brief to support and enhance the provision of blended learning throughout the university. The resulting program, ―Learning Design Live‖ (LDL) is informed by Rogers‘ theory of innovation and diffusion (2003) and structured according to Wilson‘s framework for faculty development (2007). This paper discusses the program‘s design and structure, considers the program‘s impact on academic capacity in blended learning within the institution, and reflects on future directions for the program and emerging insights into blended learning and participant engagement for both staff and students

    Xystodesmidae Cook 1895

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    Family Xystodesmidae Cook, 1895 <p> <b>Subfamily Xystodesminae Cook, 1895</b></p> <p> <b>Tribe Xystocheirini Hoffman, 1980</b></p> <p> Hoffman (1999) mistakenly attributed tribal authorship to Cook without a date, perhaps because he confused this name with Xystodesmidae /inae, which Cook (1895) did author, or because Cook (1904) subsequently authored the genus. However, the first usage of <i>Xystocheir</i> at the family-group level was by Hoffman (1980), as he then noted, and authorship is properly attributed to him.</p>Published as part of <i>Shelley, Rowland M., Smith, Jamie M. & Ross, Deren J., 2014, Variation and pigmentation in the milliped, Xystocheir brachymacris Shelley, 1996, from the northern Sierra Nevada foothills, California, USA (Polydesmida: Xystodesmidae: Xystocheirini), pp. 1-6 in Insecta Mundi 2014 (371)</i> on page 2, DOI: <a href="http://zenodo.org/record/5179327">10.5281/zenodo.5179327</a&gt

    A review of the scholarship on Ebenezer Cook and a critical assessment of his works

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    Interest in Ebenezer Cook has increased steadily, if slowly, since Moses Coit Tyler wrote an enthusiastic critique of The Sot-weed Factor in A History of American Literature, 1607-1765 in 1878. Much of that interest, however, has been little more than curiosity about a minor poet who remains an elusive literary figure of early eighteenth-century Maryland; even today, in spite of several recent assessments of his major poem s, relatively little critical attention has been given to the works of this often robust and witty author who wrote what are apparently the first American Hudibrastic poem, the first American mock-heroic, and the first belletristic work composed and published in the colonies south of Pennsylvania. Neither has there ever been a complete edition of the Cook canon, which consists, as far as we know, of three major poems--The Sotweed Factor (1708, revised extensively in 1731), Sotweed Redivivus (1730), and The History of Colonel Nathaniel Bacon's Rebellion in Virginia (1731)--and four elegies addressed to prominent Maryland citizens of Cook's day. This dissertation provides a comprehensive study of Ebenezer Cook that include critical analyses of all his known poems and transcriptions of the current canon based on first editions or earliest-known copies and manuscripts as w ell as historical background and commentary (much of Cook's poetry contains observations on the political, social, and economic issues of contemporary Maryland), bibliographical data, and a survey of Cook scholarship

    Effects of pH on the speciation coefficients in models of bromide influence on the formation of trihalomethanes and haloacetic acids

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    Data source: Supplementary data, http://www.sciencedirect.com/science/article/pii/S0043135414003777#appd001Abstract not availablePaolo Roccaro,Gregory V. Korshin, David Cook, Christopher W.K. Chow, Mary Drika

    Nitrogen metabolism in Mycobacterium smegmatis

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    Nitrogen is an essential component of the bacterial cell and bacteria have developed elaborate regulatory mechanisms used to control the uptake, assimilation and metabolism of nitrogen. In this thesis, I have developed a nitrogen-limited continuous culture system to gain further insights into nitrogen metabolism in mycobacteria and their response to nitrogen limitation. I identified 357 differentially expressed genes in response to nitrogen limitation in continuous culture, including changes in amino acid metabolic pathways. I found 26 transcriptional regulators that mediated the global transcriptomic response of Mycobacterium smegmatis to nitrogen limitation and I identified several non-coding RNAs that might be involved in the regulation of nitrogen- regulated gene expression. Subsequently, I characterised two differentially expressed transcriptional regulators, AmtR (MSMEG_4300) and CadC (MSMEG_3297) using a combination of genome-wide expression profiling, physiological, biochemical and biophysical analyses. I identified the AmtR regulon and showed that AmtR was a transcriptional repressor of an urea degradation pathway. I identified xanthine and allantoin as ligands of mycobacterial AmtR and showed that addition of these metabolites had no effect on the release of AmtR from DNA. In further work, I demonstrated that deletion of the gene cadC in M. smegmatis resulted in a severe growth defect manifested as cell lysis during growth on rich medium. Subsequently, I identified the CadC regulon that included genes involved in the diaminopimelate (DAP) and lysine biosynthesis pathway. Supplementation with DAP or lysine could not rescue the growth defect of the ∆cadC mutant. Furthermore, I showed that M. smegmatis has a high-affinity lysine uptake system that exhibited high rates of lysine transport during growth in minimal medium, which was significantly reduced during growth in rich medium. My data suggest that a ∆cadC mutant is defective in the generation or replenishment of intracellular lysine and DAP levels that are essential for growth and survival in mycobacteria. I conclude that M. smegmatis has a broad network of regulatory systems that together enable M. smegmatis to adapt its nitrogen metabolism to rapidly changing environments

    Purification, crystallization, and properties of F1-ATPase complexes from the thermoalkaliphilic Bacillus sp. strain TA2.A1.

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    Recently, we reported the cloning of the atp operon encoding for the F(1)F(0)-ATP synthase from the extremely thermoalkaliphilic bacterium Bacillus sp. strain TA2.A1. In this study, the genes encoding the F(1) moiety of the enzyme complex were cloned from the atp operon into the vector pTrc99A and expressed in Escherichia coli in two variant complexes, F(1)-wt consisting of subunits alpha(3)beta(3)gammadeltaepsilon and F(1)Deltadelta lacking the entire delta-subunit as a prerequisite for overproduction and crystallization trials. Both F(1)-wt and F(1)Deltadelta were successfully overproduced in E. coli and purified in high yield and purity. F(1)Deltadelta was crystallized by micro-batch screening yielding three-dimensional crystals that diffracted to a resolution of 3.1A using a synchrotron radiation source. After establishing cryo and dehydrating conditions, a complete set of diffraction data was collected from a single crystal. No crystals were obtained with F(1)-wt. Data processing of diffraction patterns showed that F(1)Deltadelta crystals belong to the orthorhombic space group P2(1)2(1)2(1) with unit cell parameters of a=121.70, b=174.80, and c=223.50A, alpha, beta, gamma=90.000. The asymmetric unit contained one molecule of bacterial F(1)Deltadelta with a corresponding volume per protein weight (V(M)) of 3.25A(3) Da(-1) and a solvent content of 62.1%. Silver staining of single crystals of F(1)Deltadelta analyzed by SDS-PAGE revealed four bands alpha, beta, gamma, and epsilon with identical M(r)-values as those found in the native F(1)F(0)-ATP synthase isolated from strain TA2.A1 membranes. ATPase assays of F(1)Deltadelta crystals exhibited latent ATP hydrolytic activity that was highly stimulated by lauryldimethylamine oxide, a hallmark of the native enzyme

    Nitrogen metabolism in Mycobacterium smegmatis

    No full text
    Nitrogen is an essential component of the bacterial cell and bacteria have developed elaborate regulatory mechanisms used to control the uptake, assimilation and metabolism of nitrogen. In this thesis, I have developed a nitrogen-limited continuous culture system to gain further insights into nitrogen metabolism in mycobacteria and their response to nitrogen limitation. I identified 357 differentially expressed genes in response to nitrogen limitation in continuous culture, including changes in amino acid metabolic pathways. I found 26 transcriptional regulators that mediated the global transcriptomic response of Mycobacterium smegmatis to nitrogen limitation and I identified several non-coding RNAs that might be involved in the regulation of nitrogen- regulated gene expression. Subsequently, I characterised two differentially expressed transcriptional regulators, AmtR (MSMEG_4300) and CadC (MSMEG_3297) using a combination of genome-wide expression profiling, physiological, biochemical and biophysical analyses. I identified the AmtR regulon and showed that AmtR was a transcriptional repressor of an urea degradation pathway. I identified xanthine and allantoin as ligands of mycobacterial AmtR and showed that addition of these metabolites had no effect on the release of AmtR from DNA. In further work, I demonstrated that deletion of the gene cadC in M. smegmatis resulted in a severe growth defect manifested as cell lysis during growth on rich medium. Subsequently, I identified the CadC regulon that included genes involved in the diaminopimelate (DAP) and lysine biosynthesis pathway. Supplementation with DAP or lysine could not rescue the growth defect of the ∆cadC mutant. Furthermore, I showed that M. smegmatis has a high-affinity lysine uptake system that exhibited high rates of lysine transport during growth in minimal medium, which was significantly reduced during growth in rich medium. My data suggest that a ∆cadC mutant is defective in the generation or replenishment of intracellular lysine and DAP levels that are essential for growth and survival in mycobacteria. I conclude that M. smegmatis has a broad network of regulatory systems that together enable M. smegmatis to adapt its nitrogen metabolism to rapidly changing environments
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