39 research outputs found
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No full textKristyn Hardy is a first year student at Louisiana Tech University studying English. Her goal is to one day become a published author. She is from a small town in Arkansas and was raised in a family that emphasizes creativity above all else. Kristyn hopes that her piece embodies this ideal
Invisible pathways: entrepreneurship by queer women of color in Newark
No full textThis thesis challenges ideas about gentrification and queer economic power by examining the oral histories of queer women of color who are engaged in entrepreneurial endeavors in the city of Newark, New Jersey. Centering the experiences of black lesbian entrepreneurs complicates the dominant conception of queer market capitalism as a negative where the focus tends to be on the contributions of white gay men and, to a lesser extent, white lesbians. Through the use of oral history as a member of the Queer Newark Oral History Project at Rutgers University, Newark and drawing on the scholarship of historians such as David K. Johnson, Jeffrey Escoffier, Rochella Thorpe, Mark Krasovic, Kath Weston and Lisa B. Rofel, among others I place the contributions of black queer women within the historical context of queer economies and consumerism as well as within Newark’s economic history. Positioned astride these intersecting black, queer, and urban histories, black lesbian entrepreneurs are currently occupying leadership roles within economic networks that challenge the model of gentrification in a city that is experiencing immense economic development. Whether the city’s redevelopment will benefit Newark residents without displacement remains to be seen. Not only are these women shaping a new era of the city’s economic history to be more inclusive, but they are also solidifying a queer culture landscape wherein queer black women are accumulating power amidst the corporate giants rising up around them.M.A.Includes bibliographical referencesby Kristyn Scorson
The Arab Spring: where was the EU, and what is its future in the region? Jean Monnet/Robert Schuman Paper Series Vol. 13 No. 4, February 2013
No full textFrom the Introduction. In 2010 the martyring of Mohamed Bouazizi began a ripple of civil uprisings across the Middle East, and would lead to a wave of revolutions that the media would dub the Arab Spring. From North Africa to the Gulf Region, these civil uprisings made major headlines but found little intervention on behalf of world superpowers such as the United States or the European Union. Acting as more of an observer than as an active participant in these revolutions, it would seem that the European Union played a small role in preventing civil unrest, or in aiding in the policing of these oppressive governments. By example of the passive position held by Europe during these revolutions, the EU appears to be ill equipped to handle security issues such as the massive revolutionary chain witnessed across the Mediterranean. Now, however, they have a new opportunity to be involved in a post- Arab Spring Mediterranean.
This paper seeks to address some reasons behind the Arab Spring, describe the institutional framework previously and currently in place, as well as to analyze the progress of Europe’s relationship with the Mediterranean by analyzing the EU’s past and current role in the Mediterranean. It will also look at critiques of the EU’s role in the Arab Spring, as well as the opportunities to be taken in the Mediterranean region
Solution mediated phase transformation: Investigating using a novel flow-through dissolution apparatus
No full textDrugs that are poorly soluble in water often have low or variable absorption after oral administration. Soluble salts and amorphous solids can be formed to increase the solubility of these poorly soluble pharmaceutical compounds. Solution mediated transformation (SMPT) is the precipitation of the less soluble solid form during dissolution of the more soluble form. SMPT can decrease the dissolution rate during in vitro evaluations, and ultimately in vivo resulting in lower bioavailability and therapeutic effectiveness. In this study we investigated the SMPT of amorphous solids and soluble salt forms during dissolution in a novel flow-through apparatus. ^ The apparatus was designed to utilize small samples sizes and enable viewing of solids during dissolution. Intrinsic dissolution rates of the solids were measured under well-defined hydrodynamic conditions. In all cases studied, changes in hydrodynamics did not affect the time course of SMPT. The flow-through configuration enabled measurement of dissolution rate rather than the traditional cumulative amount dissolved. A decrease in dissolution rate with time occurred immediately upon exposure to aqueous medium, indicating SMPT occurred immediately on exposure to aqueous solution. ^ The amorphous form of the drug, indomethacin, was prepared by several methods. SMPT of the higher solubility amorphous form to the lower solubility crystalline form was confirmed by in situ Raman microscopy and polarized light microscopy. The kinetics of transformation of amorphous indomethacin was found to be highly dependant on the processing method and presence of crystalline impurity. Dissolution appears to be more sensitive to differences in solid form than many of the traditional solids characterization techniques. ^ The solution mediated phase transformation of two salts, haloperidol mesylate and haloperidol chloride, to the free base form was found to be dependant on the buffer concentration at pH 7. As buffer concentration increased, the dissolution rates and time of conversion decreased. Additionally, the SMPT of haloperidol mesylate, at pH 7 exhibited complex behavior as a function of the concentration of an ionic surfactant, sodium lauryl sulfate. ^ Solution composition and solid characteristics, not hydrodynamics, affect the time course of SMPT.
Solution-Mediated Phase Transformation of Haloperidol Mesylate in the Presence of Sodium Lauryl Sulfate
No full textExploring Circle Area with Radius Squares (pp. 59--64)
No full textThe author describes an activity designed to foster student understanding of the formula forthe area of a circle using radius squares. In the lesson, sixth graders discover thatπnumber of radius squares are needed to cover a circle
Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice
No full textKristyn A Liu1†, Laura M Lashinger1†, Audrey J Rasmussen1† and Stephen D Hursting12*
Author Affiliations
1 Department of Nutritional Sciences, University of Texas at Austin, Austin, TX 78723, USA
2 Department of Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer Center, 1808 Park Road 1c, Smithville, TX 78957, USABackground: The risk of pancreatic cancer, the 4th deadliest cancer for both men and women in the United States, is increased by obesity. Calorie restriction (CR) is a well-known dietary regimen that prevents or reverses obesity and suppresses tumorigenesis in a variety of animal models, at least in part via inhibition of mammalian target of rapamycin (mTOR) signaling. Branched-chain amino acids (BCAA), especially leucine, activate mTOR and enhance growth and proliferation of myocytes and epithelial cells, which is why leucine is a popular supplement among athletes. Leucine is also increasingly being used as a treatment for pancreatic cancer cachexia, but the effects of leucine supplementation on pancreatic tumor growth have not been elucidated. Results: Supplementation with leucine increased pancreatic tumor growth in both lean (104 ± 17 mm3 versus 46 ± 13 mm3; P <0.05) and overweight (367 ± 45 mm3 versus 230 ± 39 mm3; P <0.01) mice, but tumor enhancement was associated with different biological outcomes depending on the diet. In the lean mice, leucine increased phosphorylation of mTOR and downstream effector S6 ribosomal protein, but in the overweight mice, leucine reduced glucose clearance and thus increased the amount of circulating glucose available to the tumor. Conclusion: These findings show that leucine supplementation enhances tumor growth in both lean and overweight mice through diet-dependent effects in a murine model of pancreatic cancer, suggesting caution against the clinical use of leucine supplementation for the purposes of skeletal muscle enhancement in cachectic patients.Nutritional Science
Solution-Mediated Phase Transformation of Salts During Dissolution: Investigation Using Haloperidol as a Model Drug
No full textCrystallization of Amorphous Indomethacin during Dissolution: Effect of Processing and Annealing
No full textThe crystallization of amorphous drugs during dissolution is a type of solution mediated phase transformation that can reduce the bioavailability enhancement one hoped to gain from the amorphous state. The goal of this study was to explore the effects of processing on the dissolution performance of amorphous indomethacin. The amorphous solids were prepared by four techniques, quench cooling the melted solid, cryogrinding γ indomethacin amorphous for 1 or 3 h and quench cooling the solid followed by 1 h of cryogrinding. Dissolution results assessed in a flow-through intrinsic dissolution apparatus reveal decreases in the dissolution rate of amorphous indomethacin during the experimental time frame indicating that a solution mediated phase transformation has occurred. The amorphous solids prepared by melt quenching and melt quenching followed by cryogrinding showed a significant dissolution rate advantage over the γ form of indomethacin. In contrast, indomethacin that was cryoground amorphous for 1 or 3 h did not show any dissolution rate advantage over the crystalline material. Transformation was confirmed by in situ Raman microscopy and polarized light microscopy with differences seen in the nature of the crystals apparent on the surface of the dissolving solid. A portion of the melt quenched amorphous sample was annealed at 25 °C and 0% relative humidity to induce partial crystallization of γ indomethacin. As crystallinity increased, the dissolution rate decreased. The transformation time of partially amorphous indomethacin was not dependent on the level of crystallinity present, indicating only a small fraction of crystalline material needs to be present to affect the kinetics of crystallization. The solution mediated phase transformation of amorphous indomethacin is affected by the processing method even though all solids were confirmed amorphous by polarized light microscopy and X-ray diffraction. Dissolution may distinguish differences in amorphous solids that other methods cannot discern
Final Argumentative Essay
No full textFor this argumentative essay we will be discussing issues that are present around the LGBT community. Issues of equality, sexism, racism and the lack of diversity in our daily lives. The center of this debate whom is an advocator is an artist, author and educator, Vivek Shraya. Shraya is a transgender female herself and has done a lot to promote issue surrounding the LGBT and mental health especially during covid. Shraya has written I ten books, many of which have received awards. She has done some interviews, lectures, videos as well as a focus on the art. Shraya is based in Canada and resided with her white straight looking boyfriend whom has it a lot easier in life then she does because of whom she is. We will argue that art is essential to our lives and it was especially important during covid for reasons that many may not notice, understand or agree with
