1,721,336 research outputs found
rDNA magnification in D. melanogaster: state of rDNA copies following the first step.
No full textD. melanogaster males of XYbb/O genetic constitution undergoing rDNA magnification were mated singly to XXbb+/O females, yielding XYbb/O male progeny, and to XNO- w sn bb+ females, yielding XYbb/XNO- females. The male and female offspring were scored for the bb+ phenotype. Results show that there is a higher percentage of bb+ flies in the XYbb/O male progeny than in XYbb/XNO- female progeny, in single crosses as well as in the combined data. rRNA/DNA hybridization experiments agree with this observation, by showing that the rDNA content in the progeny of premagnified flies was higher in the sons than in the daughters. These data indicate that the increase of ribosomal RNA genes is not due to a stable event such as an unequal mitotic sister exchange, whereas they do not contrast with the extracopy model
Patient-based outcomes and quality of life
Full text linkPatient‐based outcomes complement clinical data with patients’ self‐evaluation of their physical, psychological, and social well‐being, and as such facilitate clinical decision‐making, assessing the quality of care provided, and evaluating practices and policies. Some validated generic oral health‐related quality of life measures used in recent research indicated a high performance. There is a proportional relationship between the quality of life and periodontitis, ie, the higher the level of periodontitis, the poorer the oral health‐related quality of life. This relationship is heightened by the presence of symptoms such as bleeding, halitosis, and mobility. On the other hand, periodontal treatment has demonstrated the capability to improve quality of life substantially. Future research should focus on questionnaires that are able to explain the interlinked pathways between periodontal conditions, approaches to treatment approaches, and patients’ well‐being. The acquisition of new knowledge in the field is essential for the whole community, as we treat people not millimeters
A New Electrical Power System Architecture For Delfi-PQ
No full textDue to strict constraint regarding the volume of a PocketQube (50x50x50 mm) it is crucial to reduce the space that is consumed by the satellite bus subsystems. This paper focuses on a new architecture for the electrical subsystem in order to reduce its volume and increase the usage of empty surfaces inside the satellite. This increment in volume efficiency is going to be achieved by splitting the electrical power system on different surfaces and reducing the number of required voltage regulators. This modular approach is going to be realized by two main steps. First, removing the regulated bus from the satellite and delivering an unregulated bus to the subsystems. This will also give flexibility to other subsystems to use a voltage level which are more suitable for their requirements. Secondly, the internal side of the solar panels’ are going to be used for MPPT (maximum power point tracking) circuits, actually achieving a distributed power generation system, similar to ground-based solar power generation systems. The battery board is going to be a separate board with its dedicated communication lines and will also act as an interface between the solar panels and power distribution board via simple spring loaded connectors. This latter solution helps reducing dramatically the number of cables in the satellite,thus simplifying integration. The main objective of this work is turning the EPS (electrical power system) into a more flexible, scalable and volume-efficient system by a physical relocation of its components and a lean approach. The new EPS will be functionally and environmentally tested in a flight representative satellite model with the aim to verify its simplification in integration, assess its true performance as well as its reliability during launch vibration which especially includes spring-loaded connectors.Clean RoomSpace Systems EgineeringSpace Engineerin
Periodontal therapy and cardiovascular risk
Full text linkCardiovascular diseases are the worldwide leading cause of mortality. Cardiovascular diseases are noncommunicable conditions with a complex pathogenesis, and their clinical manifestations include major cardiovascular events such as myocardial infarction and stroke. Epidemiologic evidence suggests a consistent association between periodontitis and increased risk of cardiovascular diseases. Some evidence supports a beneficial effect of the treatment of periodontitis on both surrogate and hard cardiovascular outcomes. This narrative review has been conducted as an update of the most recent evidence on the effects of periodontitis treatment on cardiovascular outcomes since the last commissioned review of the European Federation of Periodontology‐American Academy of Periodontology World Workshop in 2012. Newer evidence originating from published randomized controlled trials confirms a positive effect of periodontal treatment on surrogate measures of cardiovascular diseases, whereas there have been no randomized controlled trials investigating the effect of periodontal treatment on the incidence of cardiovascular disease events such as myocardial infarction and stroke. In conclusion, there is sufficient evidence from observational and experimental studies on surrogate cardiovascular measures to justify the design and conduct of appropriately powered randomized controlled trials investigating the effect of effective periodontal interventions on cardiovascular disease outcomes (ie, myocardial infarction and stroke) with adequate control of traditional cardiovascular risk factors
TERAPIA CHIMICA DELLE CISTI: VALUTAZIONE SPERIMENTALE SUI TESSUTI CISTICI. NOTA 2: CONNETTIVO E FLOGOSI
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