123,712 research outputs found
Un lungo governo della diocesi: mecenatismo e munificenza di Prospero Lambertini, vescovo di Bologna
No full textDestinato a una brillante carriera ecclesiastica, che lo avrebbe condotto “inopinatamente” a rivestire la suprema autorità religiosa, il bolognese Prospero Lambertini è artefice di un’azione pastorale guidata da intenti riformatori e aperta al moderno pensiero sperimentale galileiano.
Fulcro del rinnovamento culturale cittadino, Palazzo Poggi – sede dell’Istituto delle Scienze e dell’Accademia Clementina, di recente fondazione – è l’istituzione da lui privilegiata come beneficiaria di risorse e provvedimenti durante il proprio mandato a vescovo di Bologna (1731), mantenuto anche dopo la nomina a pontefice (1740).
L’intensa opera di finanziamento a vantaggio di Palazzo Poggi – che comporterà la realizzazione della stanza di anatomia, il dono di importanti fondi librari, di raccolte di gessi e di stampe – si inaugura, in realtà, già nel 1726, con la richiesta da parte di Lambertini di una pala da collocare nella cappella dell’edificio. Commissionata a Marcantonio Franceschini, maestro di fama internazionale e accademico clementino, l’Annunciazione oggi nella chiesa di Sant’Isaia, lascia emergere le affinità del presule, ancora semplice monsignore, con le tendenze artistiche moderate, ispirate al “buon gusto” teorizzato da Ludovico Antonio Muratori (1708).
La sintonia con le posizioni critiche sostenute dall’Accademia Clementina riaffiorerà in seguito, nel corso del rifacimento degli altari della cattedrale metropolitana, le cui pale sono eseguite dai maggiori maestri operanti in città – Donato Creti, Giuseppe Marchesi detto il Sansone, Ercole Graziani, Antonio Rossi – in grado di garantire dignità e gravità consone al luogo, in cui si celebra il ministero sacerdotale e il seggio episcopale. Soltanto Giuseppe Maria Crespi, fautore di un linguaggio schietto e alieno dalle convenzioni, giudicato forse non sufficientemente rispettoso del criterio del decoro, resta escluso dall’impresa, nonostante il rapporto di amichevole libertà instaurato con il vescovo bolognese, di cui fanno testo i due ritratti di Lambertini in veste di cardinale e di pontefice.
Con la salita al soglio pontifico (1740) l’impegno lambertiniano per la sua patria non viene meno, anzi si rafforza grazie al convergere nel cantiere della metropolitana di ulteriori risorse finanziarie e di manodopera qualificata di maestranze non solo bolognesi, ma anche romane. Ne reca testimonianza la sontuosità di arazzi, paramenti liturgici, suppellettile sacra conservati nel Tesoro della cattedrale bolognese, che insieme al dono del nuovo Reliquiario del Capo di San Petronio, forgiato dall’argentiere romano Francesco Giardoni e destinato alla basilica del santo patrono (1743), e della perduta Rosa d’Oro (1751), intendevano dimostrare il forte legame di Benedetto XIV con la sua città natale.
La sua benevolenza avrebbe investito l’intero territorio della diocesi: comunità monastiche femminili, chiese parrocchiali, collegiate cittadine e foranee, sarebbero state gratificate attraverso l’attuazione di impegnativi progetti di riedificazione architettonica, o con il dono di arredi e apparati con l’arma del pontefice, utili a significare simbolicamente la sua presenza, nonostante la distanza imposta dalla residenza romana. Dell’ampiezza della sua munificenza danno conto numerosi calici d’argento, piviali e parati di sete e damaschi, che una ricognizione, svolta in questa occasione, ha potuto rintracciare
Movie 2
No full textMovie 2: Supplementary Material to the paper
Paniccia, D.; Padovani, L.; Graziani, G.; Lugni, C.; Piva, R. How Free Swimming Fosters the Locomotion of a Purely Oscillating Fish-Like Body. Biomimetics 202
Quattro sculture di Giovanni Battista Ballanti Graziani da Faenza ai Musei di Rimini
No full textIl presente contributo propone di individuare l'originaria collocazione di quattro terrecotte, attribuite per motivi stilistici allo scultore faentino Giovanni Battista Ballanti Graziani e conservate al Museo della Città "L. Tonini" di Rimini, nel palazzo Pasolini Dall'Onda di Faenza, grazie al reperimento di alcune lettere inedite che collegano le opere al progetto di rinnovamento decorativo dell'edificio sovrinteso da Felice Giani e Gaetano Bertolani
Manuale di diritto commerciale
No full textl Manuale di Diritto Commerciale (Graziani, Minervini, Belviso, Santoro) giunge alla 18° edizione, come al solito aggiornato con la legislazione e la giurisprudenza recenti.
Le novità legislative prese in considerazione sono state numerose, per citarne alcune: il secondo comma dell’art. 2086 c.c. che ha introdotto l'obbligo generalizzato di predisporre assetti organizzativi adeguati dell’impresa; la riforma della disciplina dei marchi; il ripensamento della trattazione della società a responsabilità limitata sottoposta a continue nuove sollecitazioni normative.
Si è, invece, dato solo schematica notizia della bozza di Codice della Crisi dell’Impresa e dell’Insolvenza, la cui entrata in vigore, prevista per l'agosto del 2020, è stata rinviata al 1° settembre 2021 a causa della Pandemia da Covid-19
NANO-MATERIALI PER LA CONSERVAZIONE DELLE SUPERFICI STORICHE
No full textHistoric and architectural surfaces conservation is considered a more and more strategic way not only for cultural reasons, but also for positive economic and social consequences. Traditional techniques of interventions often require re-application after some years and they can be carefully used in many cases. Recent researches have tried to transfer nanotechnologies to the restoration sector so as to fill this gap. Nano-coatings, in particular with titanium dioxide (TiO2), is more and more used, because they seem to be able to keep historic architectural surfaces self-cleaned and to prevent biofouling. Thus, in this paper, TiO2 potential use on common historic materials like sandstone, limestone and tuff is presented by underlying pros and cons after laboratory-simulated tests. Results show the high potentiality of this nanomaterial for the conservation of historic surfaces by also maintaining their original visual appearance. However, particular care has to be paid when historic surfaces are highly porous and rough. This, in fact, can limit the efficiency of the TiO2-nanocoatin
Corrosion mechanisms in copper-based artifacts investigated by secondary ion mass spectrometry
No full textIn the field of ancient metallic objects belonging to the world of Cultural Heritage, copper-based artifacts represent the largest part of them. The pristine appearance of these objects as conceived by the artist or the craftsman is often concealed from our eyes due to the presence of surface corrosion patinas or crusts. This sort of extra layer can sometimes completely modify color and structure of the artwork. Therefore, understanding the formation mechanism of the corrosion layers is of fundamental importance to preserve and protect the good when it is made of copper or copper alloys. Secondary ion mass spectrometry is considered an emerging technique for the investigation of patina and crusts of corroded objects. The surface and in-depth chemistry of such complicated multilayer structures can be efficiently described with high depth (1 nm) and lateral (<50 nm) resolution by using SIMS and ToF-SIMS techniques. In this article, we summarize how information obtained from ion bombardment experiments such as the penetration profiles of reactive species, the stratigraphy of corrosion products, and the identification of emerging and surface-spalling species can improve the knowledge of the corrosion phenomena in copper-based artifacts
Temozolomide: An Update on Pharmacological Strategies to Increase its Antitumour Activity
No full textTemozolomide (TMZ) is a methylating agent with promising antitumour activity against primary or secondary
brain tumours. Through the generation of a reactive intermediate, TMZ interacts with DNA at different base site positions,
generating a wide spectrum of methyl adducts represented mainly by N-methylpurines (70%) while, at a lesser extent, by
N3-methyladenine (9%) and O6-methylguanine (5%). The antitumour activity of TMZ has been primarily attributed to O6-
methylguanine, since tumour cell sensitivity inversely correlates with the levels of O6-alkylguanine DNA alkyltransferase
and requires an intact mismatch repair system.
Even though the pharmacokinetics properties, favourable toxicity profile and antitumour activity against a broad range of
tumour types render TMZ an attractive agent in oncology, resistance to the methylating agent occurs relatively often and
strongly affects the rate and durability of clinical response in cancer patients. Thus, different strategies aimed at
counteracting resistance and increasing the efficacy of TMZ have been designed and for many of them investigation is
still underway. Herein, we provide an update on the latest findings of preclinical and clinical studies on TMZ in
combination with resistance or biological modulators and anticancer drugs with different mechanisms of action
On the Modelling of Algal Biofouling Growth on Nano-TiO2 Coated and Uncoated Limestones and Sandstones
No full textAlgal biofouling on archaeological and historic materials, as well as in modern building façade, is a common phenomenon that occurs when microorganisms of various nature adhere to the material, forming biological stains and patinas. It can significantly deteriorate the aesthetic and even mechanical quality of historic and archaeological artifacts. Thus, predicting the colonization progress of algae on treated and untreated materials can be helpful to establish appropriate schedules and methods of maintenance. In this way, the aim of this research was to modelize the algal colonization on nano-TiO2 coated and uncoated stone surfaces, usually found in historic and archaeological artifacts, by following Avrami’s theory. Particular attention was paid on correlating the model with some properties of the substrate, like roughness and porosity. Biofouling was tested on two sandstones and three limestone with different intrinsic characteristics (porosity, roughness) by means of an accelerated lab-scale test. A suspension of green alga Chlorella mirabilis and cyanobacteria Chroococcidiopsis fissurarum was used as biofouling. Digital image analysis was carried out in order to find the attachment rate and the growth of algal spots. Results show that the attachment specific rate increased linearly with time, and the assumption of a constant growth rate was acceptable. A good agreement between the simulation and the experimental results was obtained with a maximum error of 0.59%.</jats:p
Is photodecomposition more important than metabolic activation for the antitumor activity of dacarbazine (multiple letters)
No full textLev et al. (1) clearly demonstrate that the antitumor agent dacarbazine (DTIC) causes melanoma cells to secrete interleukin (IL)-8 and vascular endothelial growth factor (VEGF). The authors suggest that cytokine overexpression might render tumor cells resistant to DTIC, which is presently considered the reference drug for the treatment of malignant melanoma.
The study has been entirely conducted using light-activated DTIC without considering that DTIC requires metabolic activation by liver microsomes to generate 5(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC), which is responsible of the alkylation of nucleic acids (2). In particular, O6-methylaguanine is regarded as the major cytotoxic lesion produced by the active metabolite of DTIC (2). In fact, tumor cells expressing high levels of the O6-alkylguanine DNA alkyltransferase (AGT) are resistant to DTIC and to temozolomide, which spontaneously decomposes in aqueous solution to generate the methylating species MTIC (3, 4).
Although the importance of light protection for DTIC, to avoid toxicity due to photodecomposition products, is still controversial, it is instead well established that the antitumor activity of DTIC is mainly the result of DNA methylation.
Therefore, to assess whether IL-8 and VEGF expression in melanoma cells might limit the efficacy of DTIC, it would have been certainly more interesting to evaluate the influence of MTIC-induced DNA methylation rather than analyzing the effects of photodecomposition products, which might not substantially contribute to the antitumor effects of DTIC
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