919 research outputs found
The founder of a key European association
No full textFemale cardiologists prepared to sacrifice a family for a career are doing well in Italy,
according to Maria Grazia Modena, MD, FESC, past-president of the Italian Society
of Cardiology and chief, Institute of Cardiology, University of Modena and Reggio
Emilia, Italy. But she is frustrated that some of her colleagues seem more interested
in medical politics than cooperation. She talks to Barry Shurlock, MA, Ph
Estrogens and the heart. Do they help or hurt? How estrogen impacts the cardiovascular system
No full textExtensive epidemiological observations, clinical mechanistic
studies, and basic laboratory research have suggested that the
incidence of Cardiovascular Disease (CVD) increases with menopause
and that Hormone Replacement Therapy (HRT), or more specifically
Estrogen Replacement Therapy (ERT), is associated with beneficial
cardiovascular effects in postmenopausal women. Estrogen has a
multitude of biological effects that may account for its apparent
cardiovascular protection, including favourable effects on the lipid
profile, antioxidant activity, enhanced fibrinolysis, and a series of
actions on the vasculature. However, because estrogen affects so many
cellular processes, it is imperative to gain a better understanding of
the molecular mechanisms, both genomic and non-genomic, by which
estrogen induces cellular signals and modulates vascular responses.
While there is no question that HRT effectively mitigates troublesome
menopause symptoms, conflicting evidence about other effects of
HRT has fuelled controversy concerning its relative benefits and risks.
Moreover, it could seem that CVD protection mediated by replacement
therapy is maximum when the therapy was initiated in the absence of
signs of atherosclerosis (typically in premenopause) while it vanishes
as atherosclerosis proceeds (in the postmenopausal patient). In
addition, many questions remain regarding the effectiveness of type
of hormonal compounds, doses, regimens, route and, mainly, on time
of administration. There are data from recent literature that early
menopause and not menopause per se, is a risk factor for CVD and
that early ERT may have a role on delaying the atherosclerosis process
in postmenopausal women. We conclude that is not time yet to close
the chapter of the role of estrogens in the postmenopausal
research, in fact, in this area has begun again
Hypertension, menopause and natural antioxidants in foods and the diet
No full textWorldwide, hypertension (HTN) is the most important cardiovascular risk factor for stroke, myocardial infarction and heart failure. The issue of HTN, menopause and antioxidants in foods and diet is going to open a new scenario in the treatment of the most prevalent risk factor in postmenopausal women. HTN, in fact, in this particular phase of life, is due to an increase in body mass index and a deficiency of estrogen, which induces endothelial dysfunction and an increase in oxidative stress. The term ‘antioxidant’ refers to enzymatic and non-enzymatic complexes that prevent or inhibit oxidation of biomolecules. The main non-enzymatic antioxidants are biologic compounds found mainly in vegetables and fruits. Pharmacologic therapy is very important, but it should be the second or the alternative choice after modification of lifestyle. In this context, antioxidants and diet my help in weight control as well as in the natural substitution of estrogen’s properties
Metabolic syndrome and psychiatric comorbidity: the Modena protocol
No full textMetabolic syndrome and psychiatric comorbidity: the Modena protoco
Is it Still True that Women Live Longer than Men, But with a Worse Quality of Life?
No full textIn 1998 the WHO published a "gender challenge" for
national and international organizations, an invitation to
better assess risk factors involving women's health, to
develop preventive strategies to reduce the impact of
more afflicting diseases for women, and a major effort in
understanding why men die before women [1]. Among
such afflicting diseases, cardiovascular, depression and
comorbidities are the most important
New unusual markers in coronary syndromes
No full textVI International Learning Meeting on New Perspectives in Ischemic Heart Disease, Heart Failure Atherosclerosis and Hypertension in the Third Millenium – Course on Noninvasive Coronary Doppler: from Normal to Acute Myocardial Infarctio
Hypertension, menopause and natural antioxidants in foods and diet
No full textBook contents
Chapter contents
Worldwide, hypertension (HTN) is the most important cardiovascular risk factor for stroke, myocardial infarction and heart failure. The issue of HTN, menopause and antioxidants in foods and diet is going to open a new scenario in the treatment of the most prevalent risk factor in postmenopausal women. HTN, in fact, in this particular phase of life, is due to an increase in body mass index and a deficiency of estrogen, which induces endothelial dysfunction and an increase in oxidative stress. The term ‘antioxidant’ refers to enzymatic and non-enzymatic complexes that prevent or inhibit oxidation of biomolecules. The main non-enzymatic antioxidants are biologic compounds found mainly in vegetables and fruits. Pharmacologic therapy is very important, but it should be the second or the alternative choice after modification of lifestyle. In this context, antioxidants and diet my help in weight control as well as in the natural substitution of estrogen’s properties
Diagnostic, therapeutic and prognostic evaluation of dilated cardiomyopathy with ultrasonography
No full textTechnical variations in abdominal heterotransplants of the heart
No full textThe Authors describe the innovations by them introduced in a series of 15 experiments of abdominal heart heterotopic transplantation done in the Institute of Veterinary Physiology and Biochemistry University of Milano. Particularly they recommend the use of cardioplegia and the prolene as suture's material to reduce the ischemic time. Also they signal the importance of a new position of the transplanted heart with the apex looking at the head of the recipient. They think this position should be the best to preserve the anatomical connections between the great vessels of the guest heart
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