2,501 research outputs found
Ateles fusciceps Gray 1866
No full textAteles fusciceps Gray, 1866. Proc. Zool. Soc. Lond., 1865:733 [1866]. TYPE LOCALITY: NW Ecuador, Imbabura Prov., Hacienda Chinipamba, 1500 m. DISTRIBUTION: SE Panama to Ecuador, Colombia to W Cordillera (Paraguay). STATUS: CITES - Appendix II; IUCN - Vulnerable. SYNONYMS: dariensis Goldman, 1915; robustus J. A. Allen, 1914.Published as part of Colin P. Groves, 1993, Order Primates, pp. 243-277 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 257, DOI: 10.5281/zenodo.735312
Understanding Parenting Stress through Co-designed Self-Trackers
No full textNew parents often experience significant stress as they take on new roles and responsibilities. Stress management and mental wellbeing are two areas in which personal informatics (PI) research has gained attention, and there is an opportunity to investigate how parenting stress can be mitigated through PI practices. In this paper, we present the results of a co-designed technology probe study through which we deployed individualized self-trackers with new parents. We investigate the stress management topics new parents are interested in tracking and how A- and with what goals - -they engage in self-directed PI practices. Our findings indicate that PI practices can potentially enable parents to: re-discover positive aspects of their everyday lives; identify better-suited stress management strategies; and facilitate spousal communication about shared responsibilities. We discuss how self-tracking experiences for the mental wellness of parents can be better designed.N
Ribozyme catalysis with a twist: active state of the twister ribozyme in solution predicted from molecular simulation
No full textWe present results from molecular dynamics simulations and free energy calculations of the twister ribozyme at different stages along the reaction path to gain insight into its mechanism. The results, together with recent biochemical experiments, provide support for a mechanism involving general-acid catalysis by a conserved adenine residue in the active site. Although adenine has been previously implicated as a general acid acting through the N1 position in other ribozymes such as the hairpin and VS ribozymes, in the twister ribozyme there may be a twist. Biochemical experiments suggest that general acid catalysis may occur through the N3 position, which has never before been implicated in this role; however, currently, there is a lack of a detailed structural model for the active state of the twister ribozyme in solution that is consistent with these and other experiments. Simulations in a crystalline environment reported here are consistent with X-ray crystallographic data, and suggest that crystal packing contacts trap the RNA in an inactive conformation with U-1 in an extruded state that is incompatible with an in-line attack to the scissile phosphate. Simulations in solution, on the other hand, reveal this region to be dynamic and able to adopt a conformation where U-1 is stacked with G33. In this state, the nucleophile is in line with the scissile phosphate, and the N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respectively, as supported by mutational experiments. Free energy calculations further predict the electrostatic environment causes a shift of the microscopic pKa at the N3 position of A1 toward neutrality by approximately 5 pKa units. These results offer a unified interpretation of a broad range of currently available experimental data that points to a novel mode of general acid catalysis through the N3 position of an adenine nucleobase, thus expanding the repertoire of known mechanistic strategies employed by small nucleolytic ribozymes.Peer reviewe
Mending Canada's Employment Insurance Quilt: The Case for Restoring Equity
No full textUnder the current Employment Insurance (EI) system, long-lasting EI benefits are more easily accessed in regions with high unemployment rates than in regions with low unemployment rates where workers face tighter restrictions to access short-lived benefits. This complicated screening procedure, intended to better support the various circumstances facing unemployed workers across the country, creates a number of undesirable consequences: the most glaring being pockets of high, chronic unemployment. The goals and intentions of the EI regime should be simplified to better address the needs of Canada’s unemployed workers.Social Policy, Canada, employment insurance (EI), EI reforms
Public Policy in a Private Arena: The Case of Vocational Education and Training
No full textM.21586-1998 Colin Crouch. 30 cm. This paper is based on a seminar that he presented at the Center for Advanced Study in the Social Sciences of the Juan March Institute, Madrid, on 9 May 1995, entitled Diversity in Modern Capitalism: Examples from Vocational Education." -- T.p. Includes bibliographical references (p. 35-37
Orbit design for future SpaceChip swarm missions in a planetary atmosphere
No full textThe effect of solar radiation pressure and atmospheric drag on the orbital dynamics of satellites-on-a-chip (SpaceChips) is exploited to design equatorial long-lived orbits about the oblate Earth. The orbit energy gain due to asymmetric solar radiation pressure, considering the Earth's shadow, is used to balance the energy loss due to atmospheric drag. Future missions for a swarm of SpaceChips are proposed, where a number of small devices are released from a conventional spacecraft to perform spatially distributed measurements of the conditions in the ionosphere and exosphere. It is shown that the orbit lifetime can be extended and indeed selected through solar radiation pressure and the end-of-life re-entry of the swarm can be ensured, by exploiting atmospheric drag
Helix-plasma coupling
No full textAs efforts continue to effectively utilize the microwave frequencies
a need is apparent for a traveling wave type device capable of handling
greater power at higher frequencies . One possible solution is the
plasma microwave amplifier tube. This paper discusses an analysis of the plasma - helix coupling
problem which may hopefully lead to development of such a device
whereby the R. F. energy is coupled directly to the plasma with a
helix, rather than coupling to an electron beam as has been the case
heretofore. A theoretical analysis is presented, and the computer
solution to the analytical equations evolved and the resulting w-B
plots are included. This writer wishes to express his appreciation for the assistance
and inspiration provided by Dr. Glen A„ Gray of the U. S, Naval
Postgraduate School in carrying out this investigation.Lieutenant, United States Navyhttp://archive.org/details/helixplasmcoupli109451228
Vascular healing : cell biology and rheologic factors
No full textIssued as Progress report summary, Project E-25-M44 (continued by E-25-M80)Progress report summary has author: Colin J. Schwart
The characterization of the spike protein and a comparison of two pathotypes of avian infectious bronchitis virus
No full textVita.Eleven monoclonal antibodies (MAb) were produced to the Gray stain of IBV. Six MAbs neutralized for the Gray strain, and three of these MAbs were IgGl[ak], conformation-dependent and serotype specific. The other three neutralizing MAbs were IgG2[ak], conformation-independent and bound to six strains of IBV. An additional five MAbs were nonneutralizing, IgG1, conformation-dependent and bound only the Gray strain of IBV. In the neutralizing assays with at least two of the nonneutralizing MAbs, 5C5C9 and 9B1B6, the embryos showed no gross kidney lesions. Nine MAbs were topographically mapped to define a series of overlapping epitopes. The embryonating chicken egg (ECE) system was used to examine the pathology and viral replication of two pathotypes of IBV. Gross pathology in the lungs was demonstrated with the Ark strain, and gross pathology in the kidneys was demonstrated with the Gray strain. The study confirmed that gross pathologies associated with the respective pathotypes could consistently be reproduced in the ECE model, and that viral replication was present in the lungs and kidneys of both pathotypes. An in vivo time course study examined both the kidneys and the lungs of chicks infected with either pathotype for viral replication and gross pathology. Although viral replication in the lungs and kidneys was present on each day examined, there were distinct differences in the amount of viral RNA. A difference in the initial presentation and distribution of viral antigen was detected in the lungs and kidneys of the pathotypes. Two MAbs that defined epitopes on the spike protein and were shared by the strains tested, were examined in neutralizing assays with the Gray, Arkansas, Mass41, Conn46, and a field strain, PP14. One MAb neutralized the Gray, Mass41, and PP14, and the other MAb neutralized the Conn46 and PP14..
Vascular healing : cell biology and rheologic factors
No full textIssued as Progress report summary, Project no. E-25-M80 (continued by E-25-M44; continues E-25-614)Progress report summary has author: Colin J. Schwart
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