322,970 research outputs found
Pediatric Death by Macrophage-Activation Syndrome (MAS) Related to Epstein Barr Virus: The Role of Microbiological and Histological Postmortem Investigations.
No full textDesign and variable optimization in the adsorptive stripping voltammetric determination of rufloxacin in tablets, human plasma and urine
No full textOptimization by Experimental Design of the adsorptive stripping voltammetric parameters in the determination of cinoxacin
No full textDetermination of some quinolones in tablets, human plasma and urine by differential-pulse polarography
No full textA differential pulse polarographic method was developed for the determination of norfloxacin, cinoxacin and pipemidic. oxolinic and piromidic acids in tablets and biological fluids. Well defined peaks, useful for an accurate and precise assay, were observed in the appropriate supporting electrolyte (Britton-Robinson and phosphate buffers), depending on both the kind of preparation (tablet, plasma or urine) and the quinolone investigated. The analysis of quinolones in biological fluids requires a prior clean-up procedure (treatment with acetonitrile and 2 M potassium hydroxide for plasma and solid-liquid extraction for urine) while common excipients were found not to interfere in the tablet assay. In each of the above situations (tablet, plasma or urine), good precision of the method evaluated as the CV, was found. © 1994
A Case of Sudden Death From Takayasu Arteritis (TA): The Role of the“Histopathological Autopsy” in the Diagnosis of a Rare Disease.
No full textThe Role of Proteomics for the Forensic Estimation of Postmortem Interval (PMI):A Preliminary Experimental Study.
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Experimental design in the development of voltammetric method for the assay of omeprazole
No full textA multivariate strategy was used to optimize an adsorptive stripping voltammetric method for the determination of the antiulcer drug omeprazole. A 3/4 matrix was used for the variable screening while a central composite design was chosen in the subsequent step to evaluate the response surfaces. Simultaneous optimization of the response peak height (h(p)) and peak half width w(1/2)), the latter being a peak shape measure, was achieved. The factors accumulation time, pulse amplitude, scan rate and stirring rate were all found to be statistically significant for the response h(p), while for the response w(1/2) only the stirring rate was found to be significant. The optimized method shows a good linearity between peak height and analyte concentration in the concentration range from 8.33 x 10-9 M to 1.42 x 10- 7 M with a LOD of 6.5 x 10-9 M. The mean recovery of omeprazole in capsules was 101.9% with a SD of 2.04 (RSD = 200)
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