1,720,974 research outputs found

    Proportional assist ventilation in acute respiratory failure: Effects on breathing pattern and inspiratory effort

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    Proportional assist ventilation (PAV) is a new mode of assisted ventilation which, by applying pressure in proportion to volume (volume assist, VA) and flow (flow assist, FA), should specifically reduce the inspiratory effort needed to overcome respiratory system elastance (Ers) and resistance (Rrs), respectively. The aims of this study were to determine (1) the effects of varying the level of VA on breathing pattern, inspiratory effort, and work of breathing, and (2) the interaction between VA and FA. In eight intubated patients with acute respiratory failure, four levels of VA (20 to 80% Ers) with and without a fixed amount of FA (~50% Rrs) were evaluated. Compared with spontaneous breathing, VA increased tidal volume (VT) while respiratory rate (RR) was unchanged or fell slightly. The increase in minute ventilation (V̇E) was small and not significant. The addition of FA further increased VT while RR was significantly reduced so that V̇E remained unchanged, increasing VA produced a g..

    An adapative filter for the reduction of cardiogenic oscillation on esophageal pressure signals

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    in pulmonary monitoring the processing and interpretation of esophageal pressure signals is often complicated by strong cardiogenic oscillations (CGO). In this paper, we descibe an adaptative filter that reduces CGO based on simultaneous recordings of the electrocardiogram. The algorithm is tested in a computer simulation and on patients data. In simulation, a reduction of the mean squared errors introduced by the CGO by 87% is achieved. In patients data, the filter reduces the power in Pes in a ± 0.25Hz band around the hearth rate by 76

    COMPARISON OF STATIC AND DYNAMIC MEASUREMENTS OF INTRINSIC PEEP IN ANESTHETIZED CATS

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    Dynamic measurements of intrinsic positive end-expiratory pressure (PEEPi,dyn) considerably underestimate values obtained under static conditions (PEEPi,stat) in patients with severe airway obstruction. This may be related to regional differences in respiratory system mechanical properties and/or viscoelastic behavior. To evaluate this concept, PEEPi,stat and PEEPi,dyn were compared in six anesthetized paralyzed cats during dynamic hyperinflation produced by inverse ratio ventilation (IRV) and aerosolized methacholine (MCh). PEEPi,stat did not differ between IRV and MCh, averaging 2.70 ± 0.33 (SE) and 2.70 ± 0.25 cmH2O, respectively. PEEPi,dyn was significantly less with MCh (0.25 ± 0.05 cmH2O) than IRV (2.05 ± 0.28 cmH2O) (P < 0.0001), resulting in a lower PEEPi,dyn/PEEPi,stat ratio for MCh (0.10 ± 0.02) than for IRV (0.76 ± 0.03) (P < 0.0001). Compared with control values (33.5 ± 3.7 cmH2O · l-1 · s), maximum resistance (Rmax) was unchanged during IRV (29.1 ± 2.1 cmH2O · l-1 · s) but..
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