1,721,077 research outputs found
Grape seed extract: a potential adjunct to chemotherapy?
No full textKer Y Cheah, Gordon S Howarth, Susan EP Bastia
Influence of bacterial colonisation on glycosylation of intestinal mucin oligosaccharides during early development
No full textAbstract W1745Rebecca E. Forder, Catherine Robbe-Masselot, Gordon S. Howarth, Robert J. Hughe
Comparative effects of mistletoe extracts and 5-Fluorouracil chemotherapy on viability of Caco-2 and IEC-6 intestinal epithelial cells
No full textPoster PresentationZahra Lotfollahi, Gordon S Howarth, Ljubov Simson, Ker Y Cheah and Susan EP Bastia
Grape seed extract and dried macroalgae, Ulva lactuca Linnaeus, improve survival of greenlip abalone, Haliotis laevigata Donovan, at high water temperature
No full textAbstract not availableBrett Lange, Krishna-Lee Currie, Gordon S. Howarth, David A.J. Ston
Dietary intervention improves the survival of cultured greenlip abalone (Haliotis laevigata Donovan) at high water temperature
No full textAbstract not availableDavid A.J. Stone, Matthew S. Bansemer, Brett Lange, Elise N. Schaefer, Gordon S. Howarth, James O. Harri
Age-dependent response of digestive enzyme activities to dietary protein level and water temperature in greenlip abalone (Haliotis laevigata)
No full textAbstract not availableMatthew S. Bansemer, Jian G. Qin, James O. Harris, Elise N. Schaefer, Hanru Wang, Georgia J. Mercer, Gordon S. Howarth, David A.J. Ston
Growth and feed utilisation of greenlip abalone (Haliotis laevigata) fed nutrient enriched macroalgae
No full textAbstract not availableMatthew S. Bansemer, Jian G. Qin, James O. Harris, Duong N. Duong, Thanh Hai Hoang, Gordon S. Howarth, David A.J. Ston
Use of the Rat Grimace Scale to evaluate visceral pain in a model of chemotherapy- induced mucositis
Full text linkMucositis is a painful and often debilitating condition associated with cancer treatment. Management of associated symptoms is an important clinical consideration. Animal models are used in mucositis research to model the condition in humans in order to develop novel therapeutic agents to relieve symptoms. Previous animal studies have focused on disease severity and outcomes, but often failed to measure pain. The rat grimace scale (RGS) is a validated observational measure used to gauge pain levels experienced by rats. The aim of this study was to assess the rat grimace scale in a rat model of mucositis, and to examine whether changes in clinical signs and anxiety reflected the grimace responses recorded. We also aimed to determine whether the responses were pain-specific by administering potent opioid painkilling agents. In the present study rat grimace scores did not change significantly between treatments. Development of reliable pain assessment methods in animal models is urgently required to improve model relevance to human clinical practice, in addition to safeguarding animal welfare.Rebecca P. George, Gordon S. Howarth and Alexandra L. Whittake
Probiotics, prebiotics and synbiotics: a role in chemoprevention for colorectal cancer?
No full textMark S. Geier, Ross N. Butler and Gordon S. Howarth Colorectal cancer (CRC) is the third most common form of cancer. Current treatments including chemotherapy, radiotherapy and surgery are all associated with a high risk of complications and are not always successful, highlighting the need to develop new treatment strategies. The ingestion of probiotics, prebiotics or combinations of both (synbiotics) represents a novel new therapeutic option. Probiotics and prebiotics act to alter the intestinal microflora by increasing concentrations of beneficial bacteria such as lactobacillus and bifidobacteria, and reducing the levels of pathogenic micro-organisms. This strategy has the potential to inhibit the development and progression of neoplasia via mechanisms including; decreased intestinal inflammation, enhanced immune function and anti-tumorigenic activity, binding to potential food carcinogens including toxins found in meat products, and a reduction in bacterial enzymes which hydrolyse pre-carcinogenic compounds, such as β-glucuronidase. There is substantial experimental evidence to suggest that probiotics and prebiotics may be beneficial in the prevention and treatment of colon cancer, however to date there have been few conclusive human trials. Probiotics and prebiotics have the potential to impact significantly on the development, progression and treatment of colorectal cancer and may have a valuable role in cancer prevention.Mark S. Geier, Ross N. Butler and Gordon S. Howart
Growth factor based therapies and intestinal disease: Is glucagon-like peptide-2 the new way forward?
No full textCopyright © 2009 Published by Elsevier Ltd.Inflammatory bowel disease (IBD) is a chronic, debilitating disease associated with severe damage to the intestinal mucosa. Glucagon-like peptide-2 (GLP-2) is a potent and specific gastrointestinal growth factor that is demonstrating therapeutic potential for the prevention or treatment of an expanding number of intestinal diseases, including short bowel syndrome (SBS), small bowel enteritis and IBD. The biological activity of GLP-2 is limited due to proteolytic inactivation by the protease dipeptidyl peptidase (DP)IV. Inhibitors of DPIV activity may represent a novel strategy to prolong the growth promoting actions of GLP-2. This review outlines evidence for the clinical application of GLP-2, its degradation resistant analogue, Teduglutide, and novel DPIV inhibitors in efficacy studies utilizing pre-clinical models of intestinal damage, in particular IBD.Roger Yazbeck, Gordon S. Howarth and Catherine A. Abbotthttp://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#descriptio
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