1,059 research outputs found
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
No full textWe report the identification of substituted cis-bicyclo[3.3.0]oct-2-enes as small molecule agonists of subfamily V orphan nuclear receptors (NR5A), liver receptor homolog-1 (LRH-1) and steroidogenic factor-1 (SF-1). Using fluorescence resonance energy transfer (FRET)-based biochemical assays, compound 5a (GSK8470) was identified as a high-affinity ligand for LRH-1 and SF-1. In liver cells, 5a increased the expression of the LRH-1 target gene small heterodimer partner (SHP). Synthesis of analogues modified at three positions led to the development of compounds with functional selectivity between LRH-1 and SF-1
dim-sim
No full textThe dim-sim dataset is a collection of user-annotated music similarity triplet ratings used to evaluate music similarity search and related algorithms. Our similarity ratings are linked to the Million Song Dataset (MSD) and were collected for the following paper:
Disentangled Multidimensional Metric Learning for Music Similarity
Jongpil Lee, Nicholas J. Bryan, Justin Salamon, Zeyu Jin, and Juhan Nam.
Proceedings of the International Conference on Acoustics, Speech, and Signal Processing (ICASSP). IEEE, 2020.
@inproceedings{Lee2019MusicSimilarity,
title={Disentangled Multidimensional Metric Learning For Music Similarity},
author={Lee, Jongpil and Bryan, Nicholas J. and Salamon, Justin and Jin, Zeyu, and Nam, Juhan},
booktitle={Proceedings of the International Conference on Acoustics, Speech and Signal Processing (ICASSP)},
year={2020},
organization={IEEE}
}
We kindly request that articles and other works in which this dataset is used cite the paper as listed above.
Please see our paper or visit https://jongpillee.github.io/multi-dim-music-sim for more information
Incorporation of composite defects from ultrasonic NDE into CAD and FE models
No full textFiber-reinforced composites are widely used in aerospace industry due to their combined properties of high strength and low weight. However, owing to their complex structure, it is difficult to assess the impact of manufacturing defects and service damage on their residual life. While, ultrasonic testing (UT) is the preferred NDE method to identify the presence of defects in composites, there are no reasonable ways to model the damage and evaluate the structural integrity of composites. We have developed an automated framework to incorporate flaws and known composite damage automatically into a finite element analysis (FEA) model of composites, ultimately aiding in accessing the residual life of composites and make informed decisions regarding repairs. The framework can be used to generate a layer-by-layer 3D structural CAD model of the composite laminates replicating their manufacturing process. Outlines of structural defects, such as delaminations, are automatically detected from UT of the laminate and are incorporated into the CAD model between the appropriate layers. In addition, the framework allows for direct structural analysis of the resulting 3D CAD models with defects by automatically applying the appropriate boundary conditions. In this paper, we show a working proof-of-concept for the composite model builder with capabilities of incorporating delaminations between laminate layers and automatically preparing the CAD model for structural analysis using a FEA software.This proceeding may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This proceeding appeared in Bingol, Onur Rauf, Bryan Schiefelbein, Robert J. Grandin, Stephen D. Holland, and Adarsh Krishnamurthy. "Incorporation of composite defects from ultrasonic NDE into CAD and FE models." AIP Conference Proceedings 1806, no. 1, (2017): 150004. , and may be found at DOI: 10.1063/1.4974728. Posted with permission.</p
Hiding in Plain Sight: False Identity and the Use of Space in Akira Kurosawa's The Hidden Fortress.
No full text<p><strong>Cite</strong></p>
<p>Mead, B. (2014). Hiding in Plain Sight: False Identity and the Use of Space in Akira Kurosawa's The Hidden Fortress.. S O C R A T E S, 2(4), 1-12. Retrieved from http://www.socratesjournal.com/index.php/socrates/article/view/84</p>
<p><strong>References</strong></p>
<p>Burch, N., & Michelson, A. (1979). To the distant observer: Form and meaning in the Japanese cinema. Berkeley: University of California Press.</p>
<p>Chatman, S. (1990). Coming to terms: The rhetoric of narrative in fiction and film. Ithaca, NY: Cornell University Press.</p>
<p>Goodwin, J. (1994). Akira Kurosawa and intertextual cinema. Baltimore: Johns Hopkins University Press.</p>
<p>Howe, J. (2010). The Hidden Fortress. In J. Berra (Author), Directory of world cinema. (pp. 90-91). Bristol (UK): Intellect.</p>
<p>Prince, S. (1999). The warrior's cinema: The cinema of Akira Kurosawa. Princeton, NJ: Princeton Univ. P.</p>
<p>Richie, D. (1996). The films of Akira Kurosawa,. Berkeley: University of California Press.</p>
<p>Russell, C. (1995). Narrative mortality: Death, closure, and new wave cinemas. Minneapolis: University of Minnesota Press</p>
<p>West, D. (2006). Chasing dragons: An introduction to the martial arts film. London: I. B. Tauris.</p>
<p>Yoshimoto, M. (2000). Kurosawa: Film studies and Japanese cinema. Durham, NC: Duke University Press.</p>
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Contributions to the Science of Environmental Impact Assessment: Three Papers on the Arctic Cisco (Coregonus autumnalis) of Northern Alaska
No full textEditor's Introduction -- D. W. Norton; An Assessment of the Colville River Delta Stock of Arctic Cisco--Migrants from Canada? -- B. J. Gallaway, W. B. Griffiths, P. C. Craig, W. J. Gazey, and J. W. Helmericks; Temperature Preference of Juvenile Arctic Cisco (Coregonus autumnalis) From the Alaskan Beaufort Sea -- R. G. Fechhelm, W. H. Neill, and B. J. Gallaway; Modeling Movements and Distribution of Arctic Cisco (Coregonus autumnalis) Relative to Temperature-Salinity Regimes of the Beaufort Sea Near the Waterflood Causeway, Prudhoe Bay, Alaska. -- W. H. Neill, R. G. Fechhelm, B. J. Gallaway, J. D. Bryan, and S. W. Anderson; Notice to Author
Addendum to G. B. Bryan\u27s “The Proverbial Sherlock Holmes”: Expanding the Paremiological Catalog in the Holmesian Canon
No full textThe purpose of this paper is to reassess the use of proverbs in the adventures of Sherlock Holmes, taking as a starting point the article previously published by G. B. Bryan on this same topic in Proverbium in 1996. In it, Bryan came to the conclusion that proverbs did not abound in the series. For this reason, the collection of stories and the four novels published have been surveyed for their use of paremias in order to establish their frequency of appearance and how they are used by the author. Once a rather extensive catalog of sentences susceptible to being considered as proverbs had been gathered, they were individually checked against dictionaries to establish whether they could be labeled as such. After a detailed examination of the materials obtained, this paper contradicts the thesis presented by Bryan and demonstrates that Conan Doyle uses proverbs in his detective stories quite often, most frequently through the character of Holmes
Risk Assessment in Economic Feasibility Analysis: The Case of Ethanol Production in Texas
No full textThe objective of this study is to demonstrate the benefits of quantifying the economic viability of a proposed agribusiness under risk relative to a feasibility study which ignores risk. To achieve this objective, the economic viability of a 50 MMGPY ethanol facility in Texas is analyzed over a 10-year period in two ways: with no risk and with historical risk for prices and costs.Risk and Uncertainty,
Simple and rapid energy simulation of early-stage building designs
No full textThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 173-177).Simulation tools, when applied early in the design process, can considerably reduce the energy demand of newly constructed buildings. For a simulation tool to assist with design, it must be easy to use, provide feedback quickly, and allow rapid comparisons. Most existing tools do not meet these needs, usually because they were intended for modeling finalized building designs. Often there is no user interface, and it can take hours or days to prepare, run, and interpret results. Such tools are too sophisticated for design purposes. In this document the MIT Design Advisor is presented as a simple and rapid building energy simulation tool, developed specifically for architects and building designers. Conceptual building designs can be modeled quickly and without formal training. Results are interpreted graphically and displayed to the user in a simple user interface. Side-by-side comparisons of building designs can be made, allowing users to quickly learn which building components have the biggest impact on energy consumption (heating, cooling, and lighting), indoor daylight levels, and thermal comfort. User-specified building parameters are used together with local weather data to predict monthly and annual energy use. The heat transfer model used to make the energy predictions is explained in detail in this thesis. Calculation methods are given and validated. Agreement with existing models is quite good. The MIT Design Advisor is available at http://designadvisor.mit.edu.by Bryan J. Urban.S.M
"Know your history": J. A. Rogers, vindicationist history and the use of Black images, 2006
No full textThis study examines the scholarship of J. A. Rogers and Rogers' use of vindicationist African-American history as a tool to illustrate his own ideas about humanism. Rogers' use of One-Drop ideology, Great Man history, and the philosophy of the bran of history combined into a subtle tool for undermining the entrenched racial attitudes of white supremacy during the twentieth century. This study was based on the premise that Rogers' use of vindicationism as a tool for humanism made his particular brand of vindicationist history relevant to Africana history. A historiographic critical approach to vindicationist history is used in order to determine what relevancy vindicationism has to Africana history and to what extent Rogers' humanism infused subtle arguments, contributed to Rogers' relevancy to Africana history. An examination of the goals and methodologies of other vindicationist scholars was utilized to find points of similarity and difference with Rogers' scholarship. This contrast of Rogers with other vindicationists allowed the salient points of Rogers' relevancy to be distilled. The conclusions of this study suggest that Rogers' relevancy is in his contribution to Humanism. Rogers attempts to demystify and debunk the idea of race and the history of racial intermixing, along with his championing the idea of the unity of humanity are more relevant than his vindicationist history. Additionally this study shows that both the critics of Rogers and those vindicationist historians who have followed in his footsteps have missed the subtlety in his writing. Both have viewed Rogers merely as a vindicationist. Whereas vindicationism' s tableau of black heroes is a reactionary response to Eurocentric history, Rogers' use of One-Drop ideology to debunk the idea of race was revolutionary
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