162,624 research outputs found
Prevention of strain-related osteopenia in aseptic loosening of hip prostheses using perioperative bisphosphonate
No full text© 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:693-703, 2008Allen E. Goodship, Gordon W. Blunn, Jonathan Green and Melanie J. Coathu
Modernising regulation or regulating modernisation? The public, private and voluntary interface in adult social care
No full text[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Use of mesenchymal stem cells to enhance bone formation around revision hip replacements
No full textMichelle Korda, Gordon Blunn, Allen Goodship and Jia Hu
Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom
No full textAtypical haemolytic uraemic syndrome (aHUS) is associated with a poor prognosis with regard to survival at presentation, recovery of renal function and transplantation. It is now established that aHUS is a disease of complement dysregulation with mutations in the genes encoding both complement regulators and activators, and autoantibodies against the complement regulator factor H. Identification of the underlying molecular abnormality in an individual patient can now help to guide their future management. In these guidelines we make recommendations for the investigation and management of aHUS patients both at presentation and in the long-term. We particularly address the role of renal transplantation alone and combined liver-kidney transplantation
Complement polymorphisms: Geographical distribution and relevance to disease
No full textThe evolution of man has been characterised by recurrent episodes of migration and settlement with infectious disease a constant threat. This long history of demographic change, together with the action of evolutionary forces such as natural selection and genetic drift, has shaped human genetic diversity. In particular, the interaction between humans, pathogens and the environment has played a crucial role in generating patterns of human genetic variation. The complement system plays a crucial role in the early protective immune response after exposure to a pathogen. Pathogens, over time, have developed mechanisms to circumvent the effects of complement which in turn has led to development of a more complex complement system. During the evolution of the complement system genes coding complement proteins have evolved polymorphisms, some of which have a functional effect, and this may reflect human-pathogen interaction and geographical origin. An example is the polymorphism Ile62Val (rs800292 (A>G)) in the complement regulator Factor H gene which alters the susceptibility to age-related macular degeneration (AMD), with the Ile62 polymorphism protecting against AMD. When sub-Saharan African and European populations are compared, the frequency of this polymorphism shows a very marked geographical distribution. Polymorphisms in other complement genes such as complement factor B show similar trends. This paper describes the geographical variation present in complement genes and discusses the implications of these observations. The analysis of genetic variation in complement genes is a promising tool to unravel mechanisms of host-pathogen interaction and can provide new insights into the evolution of the human immune system. © 2011 Elsevier GmbH
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Interfacial instabilities: implications for multi-material moulding
No full textThis work investigates and identifies the mechanisms that are at work in the creation of instabilities during co-injection moulding. Two aspects are investigated, neither of which has been previously reported. One seeks to eliminate the instabilities, the other to control them to produce mechanical interlocking of incompatible polymeric materials. Complex rheological and thermodynamic interactions take place during the co-injection moulding of materials of different generic families, which need to be understood before successful multi material mouldings can be achieved. Moulding trials on miscible, compatibilised and immiscible polymer systems were carried out to determine processing parameter effects.
Analysis of tensile behaviour identified differences between injection moulding and co-injection moulding samples which are indicative of different heating and cooling regimes in the systems. Scanning electron microscopy analysis also assisted explanation of these effects. A previously unobserved bulk weakness in compatibilised systems was found. Surface profilometry was used to measure the size of disturbances at the wave fronts. The extent to which the interfacial instability occurs and to the material systems to which it applies was found. Instabilities were found or induced in all material systems investigated, including those where skin and core materials are the same. Mechanisms of instability at the melt front interface were determined and were found to be the result of stratification of elastic properties. Processing conditions were found to minimize instability by minimizing differences in elasticity at the interface. A novel process route using controlled instabilities was also proposed and investigated for the use of immiscible material systems. By controlling the moulding parameters, the potential problem of instability was used to provide a solution to bonding immiscible materials in co-injection mouldings without the use of compatibiliser
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
- …
