1,376 research outputs found
Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection
Full text linkSingle-molecule surface-enhanced Raman spectroscopy (SERS) has attracted increasing interest for chemical and biochemical sensing. Many conventional substrates have a broad distribution of SERS enhancements, which compromise reproducibility and result in slow response times for single-molecule detection. Here we report a smart plasmonic sensor that can reversibly trap a single molecule at hotspots for rapid single-molecule detection. The sensor was fabricated through electrostatic self-assembly of gold nanoparticles onto a gold/silica-coated silicon substrate, producing a high yield of uniformly distributed hotspots on the surface. The hotspots were isolated with a monolayer of a thermoresponsive polymer (poly(N-isopropylacrylamide)), which act as gates for molecular trapping at the hotspots. The sensor shows not only a good SERS reproducibility but also a capability to repetitively trap and release molecules for single-molecular sensing. The single-molecule sensitivity is experimentally verified using SERS spectral blinking and bianalyte methods
Erratum: Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
No full textIMMUNOLOGY AND INFLAMMATION: Correction for "Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination," by Sophie V. Pageon, Thibault Tabarin, Yui Yamamoto, Yuanqing Ma, John S. Bridgeman, André Cohnen, Carola Benzing, Yijun Gao, Michael D. Crowther, Katie Tungatt, Garry Dolton, Andrew K. Sewell, David A. Price, Oreste Acuto, Robert G. Parton, J. Justin Gooding, Jérémie Rossy, Jamie Rossjohn, and Katharina Gaus, which appeared in issue 37, September 13, 2016, of Proc Natl Acad Sci USA (113:E5454-5463; first published August 29, 2016; 10.1073/pnas.1607436113). The authors note that Philip R. Nicovich should be added to the author list between Yuanqing Ma and John S. Bridgeman. Philip R. Nicovich should be credited with contributing new reagents/analytic tools. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
SERS characterisation of stepwise modification of gold-coated magnetic nanoparticles with oligopeptides for the complexation of copper
No full textThe characterization of the stepwise modification of 100 nm gold-coated magnetic nanoparticles (Au@Fe3O4) by alkanethiol self assembled monolayer, oligopeptides and then copper ions using surface enhanced Raman spectroscopy (SERS). Other Members: Elizabeth Murago and J. Justin Gooding
Preparation and characterisation of an aligned carbon nanotube array on the silicon (100) surface
No full textArrays of aligned carbon nanotubes formed by self-assembly on a Si (100) surface are described. The surface of a Si (100) wafer has been modified by reaction of hydride-terminated Si (100) with ethyl undecylenate to give ethyl undecanoate self-assembled monolayers (SAMs) which were linked by stable silicon–carbon covalent bonds. The ester terminus of the monolayer was converted to an alcohol whereupon shortened carbon nanotubes were covalently attached using carbodiimide coupling. The formation of the SAM and its subsequent modification with nanotubes has been followed using a series of techniques including X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), scanning electron microscopy (SEM), IR spectroscopy and cyclic voltammetry.Jingxian Yu, Dusan Losic, Matthew Marshall, Till Böcking, John Justin Gooding and Joseph Georg
Justin Václav Prášek - the regional historian and orientalist
No full textThe diploma thesis deals with the life stories of Justin Václav Prášek, his public activities as a teacher, his contribution in the field of Oriental and regional history. We can not also forget his impact on the next generation of Czech Orientalists and his great piece of work, which led in the publication of new findings to wider public. The work is divided into three main chapters, which contain a number of sections. The first chapter is about Justin Václav Prášek´s life, his student life, his work in secondary schools as a teacher or about the unsuccessful attempts to habilitation. The second chapter discusses the work of J. V. Prášek. This chapter is divided into six sections, in which the author tries to clarify the contribution of the work of J. V. Prášek, briefly describes and evaluates it. The author acquaints the readers with Prášek´s interest in the history of Near East, trying to bring his importace in the history of Czech regional history and deals with the travel diaries. Another chapter is devoted to public activities of J. V. Prášek, his benefits for the cities Brandýs nad Labem and Klánovice. There are also mentioned assotiations that are connected with his name
Correction for Millership et al., Increased lipolysis and altered lipid homeostasis protect -synuclein-null mutant mice from diet-induced obesity
No full textCorrection for “Increased lipolysis and altered lipid homeostasis protect γ-synuclein–null mutant mice from diet-induced obesity,” by Steven Millership, Natalia Ninkina, Irina A. Guschina, Jessica Norton, Ricardo Brambilla, Pieter J. Oort, Sean H. Adams, Rowena J. Dennis, Peter J. Voshol, Justin J. Rochford, and Vladimir L. Buchman, which appeared in issue 51, December 18, 2012, of Proc Natl Acad Sci USA (109:20943–20948; first published December 3, 2012; 10.1073/pnas.1210022110). The authors note that the author name Ricardo Brambilla should instead appear as Riccardo Brambilla. The corrected author line appears below. The online version has been corrected
Polymersomes prepared from thermoresponsive fluorescent protein-polymer bioconjugates: capture of and report on drug and protein payloads
Full text linkPolymersomes provide a good platform for targeted drug delivery and the creation of complex (bio)catalytically active systems for research in synthetic biology. To realize these applications requires both spatial control over the encapsulation components in these polymersomes and a means to report where the components are in the polymersomes. To address these twin challenges, we synthesized the protein–polymer bioconjugate PNIPAM-b-amilFP497 composed of thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) and a green-fluorescent protein variant (amilFP497). Above 37?°C, this bioconjugate forms polymersomes that can (co-)encapsulate the fluorescent drug doxorubicin and the fluorescent light-harvesting protein phycoerythrin?545 (PE545). Using fluorescence lifetime imaging microscopy and Förster resonance energy transfer (FLIM-FRET), we can distinguish the co-encapsulated PE545 protein inside the polymersome membrane while doxorubicin is found both in the polymersome core and membrane
Palindromic richness
Full text linkIn this paper, we study combinatorial and structural properties of a new class of finite and infinite words that are 'rich' in palindromes in the utmost sense. A characteristic property of the so-called rich words is that all complete returns to any palindromic factor are themselves palindromes. These words encompass the well-known episturmian words, originally introduced by the second author together with Droubay and Pirillo in 2001 [X. Droubay, J. Justin, G. Pirillo, Episturmian words and some constructions of de Luca and Rauzy, Theoret. Comput. Sci. 255 (2001) 539-553]. Other examples of rich words have appeared in many different contexts. Here we present the first unified approach to the study of this intriguing family of words. Amongst our main results, we give an explicit description of the periodic rich infinite words and show that the recurrent balanced rich infinite words coincide with the balanced episturmian words. We also consider two wider classes of infinite words, namely weakly rich words and almost rich words (both strictly contain all rich words, but neither one is contained in the other). In particular, we classify all recurrent balanced weakly rich words. As a consequence, we show that any such word on at least three letters is necessarily episturmian; hence weakly rich words obey Fraenkel's conjecture. Likewise, we prove that a certain class of almost rich words obeys Fraenkel's conjecture by showing that the recurrent balanced ones are episturmian or contain at least two distinct letters with the same frequency. Lastly, we study the action of morphisms on (almost) rich words with particular interest in morphisms that preserve (almost) richness. Such morphisms belong to the class of P-morphisms that was introduced by Hof, Knill, and Simon in 1995 [A. Hof, O. Knill, B. Simon, Singular continuous spectrum for palindromic Schrödinger operators, Comm. Math. Phys. 174 (1995) 149-159]
Electron-transfer characteristics of ferrocene attached to single-walled carbon nanotubes (SWCNT) arrays directly anchored to silicon(1 0 0)
No full textHigh-density, surface-mounted ferrocene has been prepared using covalent immobilisation of an alcohol substituted ferrocene derivative to a pre-assembled single-walled carbon nanotubes directly anchored to silicon(1 0 0) surface (SWCNTs-Si). The formation of these ferrocene-modified electrodes (Fc-SWCNTs-Si) has been followed using X-ray photoelectron spectroscopy and atomic force microscopy. Electrochemical results show the surface concentration of ferrocenemethanol molecules is 9.26 × 10-8 mol cm-2, which is about 500-1000 times greater than the experimentally measured coverage of ferrocene directly attached to flat Si(1 0 0) surfaces. The reversible one-electron wave of the ferrocene/ferrocenium couple was observed at 490 mV versus Ag+/Ag and the apparent rate constant of electron transfer, kapp, was 21 s-1. These results suggest these ferrocene-modified electrodes are excellent candidates for molecular memory devices. © 2007 Elsevier Ltd. All rights reserved.Jingxian Yu, Joseph G. Shapter, Martin R. Johnston, Jamie S. Quinton, J. Justin Goodin
dim-sim
No full textThe dim-sim dataset is a collection of user-annotated music similarity triplet ratings used to evaluate music similarity search and related algorithms. Our similarity ratings are linked to the Million Song Dataset (MSD) and were collected for the following paper:
Disentangled Multidimensional Metric Learning for Music Similarity
Jongpil Lee, Nicholas J. Bryan, Justin Salamon, Zeyu Jin, and Juhan Nam.
Proceedings of the International Conference on Acoustics, Speech, and Signal Processing (ICASSP). IEEE, 2020.
@inproceedings{Lee2019MusicSimilarity,
title={Disentangled Multidimensional Metric Learning For Music Similarity},
author={Lee, Jongpil and Bryan, Nicholas J. and Salamon, Justin and Jin, Zeyu, and Nam, Juhan},
booktitle={Proceedings of the International Conference on Acoustics, Speech and Signal Processing (ICASSP)},
year={2020},
organization={IEEE}
}
We kindly request that articles and other works in which this dataset is used cite the paper as listed above.
Please see our paper or visit https://jongpillee.github.io/multi-dim-music-sim for more information
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