664 research outputs found
Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients
No full textIron misregulation promotes oxidative stress, a proposed pathological mechanism in neurodegenerative disease. The aim of this study was to evaluate serum iron metabolism indicators in 60 amyotrophic lateral sclerosis (ALS) patients and 44 age matched controls. Serum ferritin levels were significantly increased in ALS patients compared to controls (p < 0.001), while no differences in the levels of serum iron, transferrin, iron saturation or total iron binding capacity were found. Likewise no differences in C reactive protein (CRP) or caeruloplasmin were detected, suggesting that the elevated ferritin levels in ALS did not merely indicate an acute phase response. The increased ferritin level may reflect a general increase in stored iron or be a consequence of ongoing muscle degeneration
Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS
No full textIron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54)
Alpejska przestrzeń grozy w opowiadaniu E.F. Bensona
No full textThe Alpine horror space in E.F. Benson’s story The Horror-Horn The article presents the image of the Alps in the work of the British writer Edward Frederick Benson. The author focuses in her reflections on Benson’s story The Horror-Horn, still unpublished in Poland, one of the first works which feature an icon of popular culture: the abominable snowman. In his story Benson depicts the Alps in accordance with a convention typical of horror literature, though the descriptions of mountain peaks have their roots also in the folk tradition or in mythological images. An analysis illustrating Benson’s “Alpine horror” mechanism is complemented by a fragment of The Horror-Horn translated into Polish.The Alpine horror space in E.F. Benson’s story The Horror-Horn The article presents the image of the Alps in the work of the British writer Edward Frederick Benson. The author focuses in her reflections on Benson’s story The Horror-Horn, still unpublished in Poland, one of the first works which feature an icon of popular culture: the abominable snowman. In his story Benson depicts the Alps in accordance with a convention typical of horror literature, though the descriptions of mountain peaks have their roots also in the folk tradition or in mythological images. An analysis illustrating Benson’s “Alpine horror” mechanism is complemented by a fragment of The Horror-Horn translated into Polish
Book Review: Khlynina T.P., Krinko E.F. History, Politics and Nation Building in the North Caucasus: Monograph. – Rostov-on-Don, Izd-vo YuNTs RAN, 2014. – 434 p.
No full textThe author of the review reveals the research approach of the monograph’s authors – T.P. Khlynina and E.F. Krinko to the analysis of the interconnection of historical memory, politics and nation building in the North Caucasus. The author also reveals the argumentation of authors’ evaluations of Soviet nation building in the region, interactions of state power with ethnopolitical movements, methods of historical memory institutionalization in the North Caucasus
Opening van vier nieuwe laboratoria van de Afdeling der Werktuigbouwkunde van de Technische Hogeschool Delft
No full textSamenvatting van de toespraak door Prof.ir, R. van Hasselt bij de officiele opening van vier nieuwe laboratoriavan de Afdeling der Werktuigbouwkunde Boon, E.F. en Boot, J.: het Laboratorium voor Chemische Werktuigen Vahl, L.: het Laboratorium voor Koudetechniek Van Eldik Thieme, H.C.A.: het Laboratorium voor Voertuigtechniek Blok, H.: het Laboratorium voor WerktuigonderdelenWerktuigbouwkundeMechanical, Maritime and Materials Engineerin
3D Laser Scan Data: La Charce Sedimentary Outcrop, France
No full textThis .ptx file is a 3D point cloud (XYZiRGB) of a sedimentary rock outcrop near La Charce, France. It was used for the data analysis in Matlab completing the Master thesis: "Characterizing Sedimentary Outcrops with Laser Scanning: Applied to Cretaceous deep marine limestone-marl sequences in the Vocontian Basin, France". It can be opened in the open source software, CloudCompare
Effective strategy making, co-designing as a tool for effective strategic planning
No full textThe study explores the factors for success of long-term spatial development policies. The theoretic frame assumed that co-ownership of the content of a development policy is not enough for sustained support. Co-creation of a development vision with all relevant parties in a region or city would entail co-authorship, which enhances the chances for longer lasting support. The researcher, being an experienced practitioner emphasizes the importance of the way participants interact in the decision-making process, which is often seen as a black-box with surprising outputs. The novel "interactions approach" addresses the question how the experiences of participants may result in perceptions and feelings of co-ownership and more importantly, of co-authorship. The empiric study analysis five projects in four European countries. The interrelations between context and content factors established within the cases confirmed the influence on effectiveness in decision-making rounds and the eventual success of co-designing a scenario for future development. The importance of open processes so that creativity is enabled and design methods can be practiced is essential. Involving of design trained experts and facilitating a design attitude in the decision making process of development strategies increases the possibilities of innovation in future circumstances. The author hopes to bridge the worlds of planning theory and planning practice.OTBArchitecture and The Built Environmen
Untersuchungen an Dichtungen für Apparateflansche
No full textMechanical, Maritime and Materials Engineerin
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