12,206 research outputs found
Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
No full textAquaporin-4 (AQP4) is a water channel expressed on astrocytes known to regulate the exchange of fluids and solutes between the parenchyma of the central nervous system (CNS) and perivascular spaces. We hypothesized that activation of AQP4 may mediate permeability of the CNS during systemic inflammation. Here, mice were i.v. injected with fluorescent tracers of low (1 kd) and intermediate (10 kd) molecular weights 24 hours after induction of endotoxemia with i.p. LPS. Fluorescent microscopy using tissue sections and cleared half-brains showed that endotoxemia increased tracer penetrance into the brain parenchyma. Temporal and spatial distribution of tracers suggested that penetrance occurred across neurovasculature, choroid plexus, and circumventricular organs (CVOs). Treatment with the AQP4 inhibitor, AER-271, blocked tracer passage across the glia limitans and caused tracer accumulation within perivascular spaces. These data show that AQP4 mediates the flux of solutes from the perivascular space to the brain parenchyma during systemic inflammation and highlight a novel strategy to neuroprotection during sepsis.Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo termsThe student, Rafael Jaime Gonzalez Ricon, accepted the attached license on 2021-06-28 at 16:24.The student, Rafael Jaime Gonzalez Ricon, submitted this Thesis for approval on 2021-06-28 at 16:46.This Thesis was approved for publication on 2021-07-01 at 11:46.DSpace SAF Submission Ingestion Package generated from Vireo submission #16727 on 2022-01-12 at 12:43:39Made available in DSpace on 2022-01-12T21:45:23Z (GMT). No. of bitstreams: 2
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Previous issue date: 2021-07-0
Decreto, Rafael Gonzalez, 1820
No full textSpanish Language Manuscripts: Decreto, Rafael Gonzalez, 1820
Marriage record of Gonzalez, Rafael and Rodriguez, Esperanza
No full textMarriage license for Rafael Gonzalez and Esperanza Rodriguez. B.R. Gonzalez was the Notary Public
Marriage record of Gonzalez, Rafael and Blanco, Mercedes
No full textMarriage license for Rafael Gonzalez and Mercedes Blanco. Louis Milian was the Notary Public
Marriage record of Daubar, Rafael and Gonzalez, Lucrecia
No full textMarriage license for Rafael Daubar and Lucrecia Gonzalez. Pedro Duarte was the officiant
[Dolores Gonzalez and Rafael Arzáte, marriage certificate]
No full textMarriage certificate for Pedro J. Gonzalez's half-sister Dolores Gonzalez and Rafael Arzáte. On the front of the page, an illustration of an eagle biting a snake has been printed between the title "Estado de Xhihuahua" and a wide text column. The back of the page contains a text column printed above a circular seal and a signature
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[Dolores Gonzalez and Rafael Arzáte, marriage certificate]
No full textMarriage certificate for Pedro J. Gonzalez's half-sister Dolores Gonzalez and Rafael Arzáte. On the front of the page, an illustration of an eagle biting a snake has been printed between the title "Estado de Xhihuahua" and a wide text column. The back of the page contains a text column printed above a circular seal and a signature
Estudio de la estabilidad de diferentes configuraciones de plasma y fluídos
No full textFil: Gonzalez, Rafael. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Los Baños (Philippines), Gonzalez, Copeland, Curran, university President Rafael V. Palma (center) and Fischer
No full textFarewell to President Palma [Rafael V. Palma]. Campus. Dec. 15 '33. Gonzalez, Copeland, Curran, Palma [Rafael V. Palma], Fischer.GrayscalePendleton nitrate negative, Box 79 of 38
Marriage record of y Gonzalez, Rafael Blanco and Reyes, Fannie Augusta
No full textMarriage license for Rafael Blanco y Gonzalez and Fannie Augusta Reyes. Cayetano Valdes was the officiant
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