11 research outputs found
An Intersection of Computational Biology and Functional Genomics to identify Transcriptional Gene Enhancers and Their Role in Cancer
No full textDespite the critical role of gene regulation in cell development and differentiation, the major challenge remains to identify the cis-regulatory modules (CRMs). Mainly, these CRMs include enhancers, promoters and insulators that governs the spatiotemporal gene regulation. The gene regulatory networks are highly dependent on their CRMs and mostly consist of DNA motifs and epigenetic landmarks. The recent advancements in high-throughput sequencing techniques and comparative genomics analysis accelerate the discovery of enhancers, however the major obstacles are to identify the genome-wide location of these CRMs, their dynamic nature of interactions, and cis/trans location which could be hundred to thousands base pairs away from the target gene location. The goal of this literature review is to provide an insight into the CRMs specifically enhancers, how they modulate gene expression, mutations that converts normal cell into a disease-state such as cancer. Also, this embedded review article is focused on the use of computational strategies coupled with the biochemical assays to predict functional gene enhancers. The computational strategies such as window clustering, probabilistic modeling, phylogenetic footprinting and discriminative modeling are briefly discussed to scan and locate the putative gene enhancers. Besides theses, biochemical techniques such as ChIP-seq, DNA footprinting, and deletion mapping are briefly reviewed in Drosophila to predict functional gene enhancers and dissecting gene regulatory networks. In addition, this review article may help bench scientists to incorporate bioinformatics tools with biochemical techniques to scan, locate and verify gene enhancer regions within a cell. With best of our knowledge, this is a first-time effort to combine insilico, in vitro and in vivo techniques to explore the connections between CRMs and gene regulation
The Ursinus Weekly, October 24, 1949
No full textFive coed Greek organizations get set for annual hectic fall rushing season • Grid machine seeks win over Seahawks to avenge \u2748 loss • Poem reveals hope for beaten athletes • Pep rally precedes senior class dance • Soccer team drops second contest 2-0 at New Brunswick • Garnet drops Bears 20-6 with quick aerial attack • Curtis keeps lead; McMillan triumphs in golfing contest • Court squad opens practice workouts for coming season • Hockey team takes season opener 4-3 against Bryn Mawr • Traveller comes to roost at Ursinus • British lecturer and author to appear at Ursinus rostrum next Tuesday night • Rusty Reed heads paint-brush squad in campus publicity • Sky becomes limit in full-dress battle of annual banquet • Editorial: Sororities and fraternities • Varsity Club selects Farina band • Initial \u2753 officers take over duties following introduction at frosh banquet • Men choose three for MSGA positions • Music clubs offer two merit awards • Hungarian to talk at vesper service • Stassen views theories shaping world cultures • Sophs offer variety in coming week-end • Allen and Aiken cop leading portrayals in December play • Fulbright act gives full financial aid for foreign study • Kitchen adds new refrigerator, other equipment during summerhttps://digitalcommons.ursinus.edu/weekly/1574/thumbnail.jp
Two cultures, one room: investigating language and gender in Kuwait
No full textPhDKuwait is a gender-segregated country. Its conservative cultural ideology is evident in all
areas of social life, including the way people communicate. Men and women have to
make conscious language choices during everyday interaction. Certain aspects of Kuwaiti
conversational registers are exclusive to either men or women, which reflects not only
men’s and women’s separate socialization as children but also separate lifestyles as
adults. Kuwait’s gendered context is therefore bound to be unique and of particular
sociolinguistic interest, especially since mainstream language and gender literature has
more often focused on English-speaking cultures. Thus, there is little knowledge of Arab
gender-segregated cultures and this could possibly be due to complications that the
researcher inevitably encounters when examining a sensitive issue such as gender within
these constraints. The present research study investigates mixed interaction between
Kuwaiti men and women in online chat rooms. In this particular online context, chat
room users employ interactional strategies to negotiate the norms of heterosexual
interaction which are often non-existent in offline Kuwaiti society. A combined
framework of sociolinguistic, ethnographic methods is adopted to examine chat room
interactional choices that enable men and women to construct gendered chat room
identities as well as create a virtual online community of practice without undermining offline gender norms
Literary and theological responses to the Holocaust
No full textSIGLEAvailable from British Library Document Supply Centre- DSC:DX86116 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Beyond the pink: (post) youth iconography in cinema
No full textBeyond the Pink: (Post) Youth Iconography in Cinema is a project in cultural time travel. It cuts up linear cinematic narratives to develop a hop-scotched history of youth, Generation X and (post) youth culture. I focus upon the pleasures, pedagogies and (un)popular politics of a filmic genre that continues to be dismissed as unworthy of intellectual debate. Accelerated culture and the discourse of celebrity have blurred the crisp divisions between fine art and crude commodity, the meaningful and meaningless, and real and fictive, unsettling the binary logic that assigns importance to certain texts and not others. This research project prises open that awkward space between representation and experience.
Analysts require methods and structures through which to manage historical change and textual movement. Through cinema, macro-politics of identity emerge from the micro-politics of the narrative. Prom politics and mallrat musings become imbued with social significance that speak in the literacies available to youth. It grants the ephemerality and liminality of an experience a tactile trace. I select moments of experience for Generation X youth and specific icons - Happy Harry Hardon, Molly Ringwald, the Spice Girls, the Bitch, the invisible raver, teen time travellers Marty McFly and Donnie Darko, and the slacker - to reveal the archetypes and ideologies that punctuate the cinematic landscape. The tracked figures do not configure a smooth historical arc. It is in the rifts and conflicts of diverse narratives and subjectivities where attention is focused.
This research imperative necessitates the presentation of a series of essays arranged in a tripartite framework. The first section proposes theoretical paradigms for a tethered analysis of filmic texts and Generation X. The second segment explores sites of struggle in public spaces and time. The final section leaves the landscape of post-Generation X to forge the relationship between history, power and youth identity. I particularly focus on the iconography, ideologies and imaginings of young women to lead the discussion of the shifts in the experience and representations of youth. By reinserting women into studies of film, it is imperative to stress that this is not a dissertation in, and of, women's cinema. Rather, it serves as an historical corrective to the filmic database.
The existing literature on youth cinema is disappointing and narrow in its trajectories. Timothy Shary's Generation Multiplex: The Image of Youth in Contemporary American Cinema and Jon Lewis' The Road to Romance and Ruin: Teen Films and Youth Culture exemplify the difficulties of capturing the complexities of individual films when they are collated in artificial and stifling categories. At one end of the analytical spectrum is the critique that comes with the caveat of 'it's just another teen movie'. Jonathon Bernstein's monograph Pretty in Pink: The Golden Age of Teenage Movies is one such example which derails into acerbic diatribes and intellectual dismissal. The Cinema of Generation X: A Critical Study by Peter Hanson is a more successful project that is interested in the influences that inform a community of filmmakers than arriving at a catalogue of generic themes and narratives. There is an emphasis on the synergy between text, producer and readership.
I continue this relationship explored by Hanson, but further accent the politics of film. The original contribution to knowledge offered by this doctoral thesis is a detailed study of (post) youth popular culture, building into a model for Generation X cinema, activating the interdisciplinary perspectives from film and cultural studies. With its adaptability into diverse media forms, cultural studies paradigms allow navigation through the expansive landscape of popular culture. It traverses beyond simple textual analyses to consider a text's cultural currency. As an important carrier of meaning and sensory memories, cinema allows for alternative accounts that are denied in authorised history. As a unique form with its own visual literacy, screen theory is needed to refine observations. This unique melding of screen and cultural studies underscores the convergent relationship between text, readership, production and politics.
This doctoral thesis activates concepts and methods of generationalism, nationalism, social history and cultural practice. There is a dialogue between the chapters that crosses over text and time. The 1980s of Molly Ringwald shadows the dystopia of Donnie Darko. The celebrity status of the Spice Girls clashes with the frustrated invisibility of the female raver. Douglas Coupland's vision of Generation X in 1991 has evolved into Richard Linklater's documentation of post-youth in the new millenium. Leaping between decades through time travel in cinema, I argue that the nostalgic past and projections for the future evoke the preoccupations and anxieties of the present
The television work of Alfred Hitchcock
No full textThe thesis uses close textual analysis to study and evaluate the television work of Alfred Hitchcock. The corpus consists of the twenty shows personally directed by Hitchcock, including his appearances before and after those shows. In response to most previous writing, which tends to compare the programmes with Hitchcock’s films (often unfairly) the thesis emphasises them as products of television. Programmes are evaluated on the basis of their perceived success as television- if they harness conditions related to television production and integrate them with narrative themes or to create meaning. Hitchcock is considered to be the major creative force in each programme.
Chapter One provides a variety of important contexts including a brief history of US television of the 1950s, key literature on Hitchcock and analyses of contemporaneous programmes not directed by Hitchcock. The textual analysis chapters (2-8) consider aesthetic or thematic programme aspects. Chapter Two studies the various roles played by Hitchcock’s appearances as series host. Chapter Three considers the impact of censorship on programmes frequently dealing with murder, violence and insanity. Chapter Four analyses Hitchcock’s implementation of varieties of voice-over narration, a common device in short dramatic forms. Chapter Five studies Hitchcock’s use of point-of-view shots, particularly in relation to their role in the delivery of the narrative twist. Chapter Six considers the key Hitchcock theme of detachment from the world. Chapter Seven looks at moments from the programmes which demonstrate how aesthetic is influenced by television production conditions.
Hitchcock created a number of television masterpieces. His achievements in television are in many ways comparable in quality and consistency to his theatrical films. Even when considered in the context of other 1950s US anthology dramas, the Hitchcock-directed programmes are superior on many levels. Elements of his film style were highly suited to television production. Many of his greatest achievements embrace and harness television production conditions in their presentation strategies to create an integration of style and meaning
The Christian ministry : case studies of preachers of the Churches of Christ in Bicol, Philippines
No full textThis thesis examines the challenges faced by the ministers of religion in Churches of Christ (Restoration Movement) in Bicol, Philippines. The goal is to do theology from below, not from above, as pastoral ministry must come from the experience of those who practice it, not from textbooks. The pastoral perspectives of the dilemmas that the ministers raise are heard, observed, documented, and then reflected upon. To do this, case studies of four preachers are used and the mga problema that they present are explored with them.
As a result, first, I introduce some of those challenges which are perplexing on the ground level and which appear to be under-researched in serious theological circles, especially in an Asian context. Second, I hope that these case studies can be used to stimulate reflection in ministerial and spiritual formation. Third, I document some of the theology and methodology of the Churches of Christ, particularly as practiced in the Philippines.
Chapter 1 explores the dichotomy between the perceived satisfaction in the pastoral ministry with the crisis of role and identity. In particular, issues such as forced exits and stress are presented while baptism and preaching are scrutinized. Chapter 2 centres on the conundrums experienced in planting a new church and being the lone planter. Chapter 3 examines three challenges–the task of ministering in a home congregation, the issue of accreditation in ministerial training, and how the minister can be a success and grow the church. Never far from the thoughts and actions of any of the Bicolano ministers is the problema of poverty, so Chapter 4 considers some of the Filipino, personal, and spiritual complexities of poverty, delineates a number of factors that need to be taken into consideration in any effort to overcome this malady and concludes with a particular reference to ministry
Theology of culture in a Japanese context: a believers' church perspective
No full textThis thesis explores an appropriate relationship between Christian faith and culture. We investigate the hallmarks of authentic theology in the West, which offer us criteria to evaluate Christianity in Japan. Because Christian faith has been concretely formed and expressed in history, an analysis and evaluation of culture is incumbent on theology. The testing ground for our research is Japan, one of the most unsuccessful Christian mission fields. Thus this is a theology of culture in a Japanese context. Through a dialogue with H. Richard Niebuhr, John Howard Yoder, and Stanley Hauerwas, we embrace a believers' church perspective as our basic vision. The believers' church critically evaluates culture and seeks to transform it by standing on the boundary between the Kingdom of God and the world, and voluntarily participates in the redemptive suffering of God with the creature. It strives to be faithful to God and to imitate Jesus Christ, instead of seeking to control the world. It trusts in God; for it is He, and not we, who is in charge of history. Examination of Japanese Christian history is conducted in the light of the criteria above, in order to consider how Japan responded to Christianity. The criteria help us see the problem of nationalism both in superficial Christianity in Japan and in Constantinian Christianity in the West. We discuss three major Japanese theologians: Kazoh Kitamori, Yasuo Furuya, and Hideo Ohki. They help us refine our criteria for suffering, for theological assessment of Japan, and for the nature of believers' church as covenant community. We find in our investigation that although Christianity has always been in a minority in Japan, the church in Japan - like the church in the West - inclines to be co-opted by political powers, which is a core problem
Peat slides : morphology, mechanisms and recovery
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
A critical edition of Derek Walcott's Omeros
No full textThe thesis is a Critical Edition of Derek Walcott’s Omeros, consisting of a Critical
Introduction and Annotations. The Critical Introduction analyses:
- Narrative
- Settings
- Metaphor and Paronomasia
- Symbolism
- Historiography
- Intertexts
- Dualism
- Autobiography
- Dialects
- Prosody.
The Annotations comment on more than 1000 references that may be obscure and on
specifics of narrative, language and prosody.
This study presents new conclusions about some aspects of Omeros:
- It challenges the prevailing view that the work is written substantially in a
variation of terza rima and shows that regular quatrains predominate.
- It demonstrates ways in which the metrics follow the sense of the narrative and
takes a more balanced position on the use of Caribbean as opposed to classical
metrics than that put forward previously.
- It identifies a paragraphic structure to the verse.
- It proposes a new prosodic structure for the significant Chapter XXX/iii.
- It extends Walcott’s recognised use of numerology into word counting the
names of characters.
- It develops the idea of Walcott’s dualism and his use of pairing and
contradiction as a dialectical method.
- It defines his wide use of paronomasia and shows that many of the puns have a
metaphorical aspect beyond mere word-play.
- It analyses some of Walcott’s symbolism.
- It identifies intertextual links to his earlier works and to some thirty other
writers, and suggests homage to Hemingway and possibly Heaney.
- It provides the first complete analysis of Walcott’s rhyme types in Omeros.
In its analysis of Omeros and in the Annotations it has included commentary from
across the critical literature, to provide some sense of other views on Walcott’s
writing, and has included as many as possible of Walcott’s own comments on Omeros
and on the writer’s task, as a background to understanding the poem
