3,220 research outputs found
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No full textHere is a curious book. Its title-page declares "The Artist's Book of Fables" but its pre-title-page has "Fables, Original and Selected, with a Memoir of the Author." After that title-page, it is identical with "Fables, Original and Selected" as in our copy printed by John Murray in 1833. There is again an AI at the front and an index of engravings and engravers at the back. I found that copy twenty years ago. I had found an inferior copy twenty-two years before that. At that time, I noted Aesopic fables here including "Stone Broth" and "The Mouse and the Oyster."This is a hardbound book (hard cover)James Northcote, R.A
Total fluid and specific beverage intake and mortality due to IHD and stroke in the Netherlands Cohort Study
No full textEen twee-dimensionaal clutterfilter voor havenradarsystemen
No full textKustnavigatiesystemen zijn van onbetwistbaar nut voor de hedendaagse scheepvaart. Reeds gedurende enkele decennia maakt de scheepvaart dankbaar gebruik van geavanceerde navigatiesystemen, die bijdragen tot een vlot en veilig manoeuvreren in drukke havens en hun aanlooproutes. Van meet af aan waren walradarsystemen geïntegreerd, met als voornaamste doel bijstand te verlenen tijdens mist en slecht zicht omstandigheden. Toename van de verkeersdichtheid alsmede de grootte en snelheid van de schepen, maakte een intensievere begeleiding noodzakelijk. In de loop der jaren is de walradar uitgegroeid van een hulpmiddel bij navigatie tot de principiële sensor van een uitgebreid scheepsbegeleidingssysteem. Gedurende het gehele etmaal, zowel bij goed als slecht weer, heeft het systeem een consulterende, assisterende en controlerende taak…Applied SciencesElectrotechniekLaboratorium voor Transmissie van Informati
Toenails: An easily accessible and long-term stable source of DNA for genetic analyses in large-scale epidemiological studies [8]
No full textPG - 1168-70 AD - Department of Health Risk Analysis and Toxicology and. FAU - van Breda, Simone G AU - van Breda SG FAU - Hogervorst, Janneke G AU - Hogervorst JG FAU - Schouten, Leo J AU - Schouten LJ FAU - Knaapen, Ad M AU - Knaapen AM FAU - van Delft, Joost H AU - van Delft JH FAU - Goldbohm, R Alexandra AU - Goldbohm RA FAU - van Schooten, Frederik J AU - van Schooten FJ FAU - van den Brandt, Piet A AU - van den Brandt PA LA - eng PT - Journal Article PL - United States TA - Clin Chem JT - Clinical chemistry JID - 9421549 SB - I
Energy restriction in childhood and adolescence and risk of prostate cancer: results from the Netherlands Cohort Study.
No full textAm J Epidemiol 2001 Sep 15;154(6):530-7 Related Articles, Books, LinkOut Energy restriction in childhood and adolescence and risk of prostate cancer: results from the Netherlands Cohort Study. Dirx MJ, van den Brandt PA, Goldbohm RA, Lumey LH. Department of Epidemiology, Faculty of Health Sciences, Maastricht University, Maastricht, the Netherlands. [email protected] This study investigated the association between prostate cancer risk and energy restriction during childhood. The authors examined the hypothesis among 58,279 men aged 55-69 years enrolled in the Netherlands Cohort Study on Diet and Cancer. Information on diet and risk factors was collected by questionnaire in 1986. Additional information was collected on residence during the Dutch Hunger Winter (1944-1945) and the World War II years (1940-1944) and father's employment status during the economic depression of 1932-1940, used as indicators of exposure. A case-cohort approach was used. After 7.3 years of follow-up (through December 1993), 903 prostate cancer cases were available for analysis. Analyses were carried out for all prostate cancer cases. The prostate cancer rate ratio for men who had lived in a western Netherlands city in 1944-1945 was 1.15 (95% confidence interval (CI): 0.80, 1.31), and the rate ratio for men who had lived in a western rural area in 1944-1945 was 1.30 (95% CI: 0.97, 1.73). Residence during the war years (1940-1944) and father's employment in 1932-1940 showed no relation to prostate cancer risk. In subgroup analyses in which exposure before, during, and after the adolescent growth spurt was evaluated, the same pattern as that of the overall data was shown. The authors found no evidence for the hypothesis that energy restriction early in life decreases prostate cancer risk later in life
A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer
No full textBACKGROUND: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. METHODS: The Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline (1986), a random subcohort of 2,589 women was selected using a case cohort analysis approach for analysis. The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Subgroup analyses were done for never-smokers to eliminate the influence of smoking; an important source of acrylamide. RESULTS: After 11.3 years of follow-up, 327, 300, and 1,835 cases of endometrial, ovarian, and breast cancer, respectively, were documented. Compared with the lowest quintile of acrylamide intake (mean intake, 8.9 mug/day), multivariable-adjusted hazard rate ratios (HR) for endometrial, ovarian, and breast cancer in the highest quintile (mean intake, 40.2 mug/day) were 1.29 [95% confidence interval (95% CI), 0.81-2.07; P(trend) = 0.18], 1.78 (95% CI, 1.10-2.88; P(trend) = 0.02), and 0.93 (95% CI, 0.73-1.19; P(trend) = 0.79), respectively. For never-smokers, the corresponding HRs were 1.99 (95% CI, 1.12-3.52; P(trend) = 0.03), 2.22 (95% CI, 1.20-4.08; P(trend) = 0.01), and 1.10 (95% CI, 0.80-1.52; P(trend) = 0.55). CONCLUSIONS: We observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Risk of breast cancer was not associated with acrylamide intake. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2304-13). AD - Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands. [email protected]. FAU - Hogervorst, Janneke G AU - Hogervorst JG FAU - Schouten, Leo J AU - Schouten LJ FAU - Konings, Erik J AU - Konings EJ FAU - Goldbohm, R Alexandra AU - Goldbohm RA FAU - van den Brandt, Piet A AU - van den Brandt PA LA - eng PT - Journal Article PL - United States TA - Cancer Epidemiol Biomarkers Prev JT - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncolog
Turbulent entrainment in a shearless mixing layer at the edge of a cloud
No full textThree-dimensional direct numerical simulations which combine the Eulerian description of temperature, vapor content and velocity with a Lagrangian ensemble of cloud water droplets are used to study the turbulent entrainment and subsequent mixing of clear air with a cloudy air filament. The study is conducted in a shearless mixing layer setup which is adjusted to realistic conditions at a cumulus cloud boundary. The magnitude of turbulent velocity fluctuations in- and outside the cloud can be varied independently. We find that the evolution of the cloud water droplet ensemble depends slightly only on the contrast of turbulent velocity fluctuations in- and outside the cloud filament. The buoyancy feedback on the flow via the evaporating droplets causes a transient amplification of all fluctuations before the turbulence eventually decays. We study the evolution of the probability density functions of droplet size as well as of supersaturation, temperature and vorticity at the droplet positions
Flyleaf of The Village Politicians, signed by author and publisher R.A. Parsons, and printed by Guardian Ltd.
No full textNewIntroduction. Flyleaf of the The Village Politicans by R.A. Parsons and printed by Guardian Ltd.DA vol. 15 no.
Non-Linear Time Series Analysis of Deep Groundwater Levels: An application to the Veluwe
No full textThe objective of this study is to improve the simulation of deep groundwater levels by time se- ries models with pre-defined impulse response functions. This is attempted by adding a conceptual non-linear root zone model to simulate the recharge series to the model and by testing the use of a separate response function for the percolation zone. Three root zone models are developed based on two different recharge mechanisms: preferential flow, percolation, and a combination of the two. The performance of these models is compared to a linear model that is commonly used in time se- ries models to simulate the recharge. The approach is applied to groundwater level measurements in the Veluwe, a largely forested area in the Netherlands characterized by thick unsaturated zones. The effect of groundwater extractions and land reclamations is added to the model to further im- prove the simulation of the groundwater levels. The models are tested on three observations wells with increasing thickness of the unsaturated zone, varying from 7 m to 29 m to 49 m. The results show that model performance is improved by the implementation of a non-linear root zone model, particularly in simulating the peaks and lows in the groundwater levels. The recharge fluxes simulated by the non-linear models show different patterns that are physically more realistic than those simulated by the linear model. It is shown that different recharge series result in simulated groundwater levels that are very similar. This is a clear example of equifinality and it is recommended to introduce new sources of information to validate the modelled processes (e.g., water content measurements of the percolation zone or actual evaporation data). For the shallow well, the models with a single response function are selected as the best. The largest improvements for the deeper groundwater levels are obtained by the addition of a separate response for the percolation zone. For example, the average deviation from the observed ground- water levels decreased 0.18 m to 0.08 m for the deepest observation well by applying the separate response function. The models with an additional response function were better at simulating the estimated time to peak, the time it takes a recharge pulse to cause a peak in the groundwater levels. The time to peak is introduced in this research as a qualitative indicator to validate the modelled processes. The simulated responses indicate that the groundwater levels respond very quickly to water that leaves the root zone, even though the percolation zone is tens of metres thick. For each of the observations wells it is investigated if adding the effect of groundwater extrac- tions or land reclamations of Flevoland to the models improves the simulation of the groundwater levels. For the shallow well it is concluded that either the effect of land reclamations or groundwater extractions needs to be taken into account. Since these two stresses are correlated, it is concluded that only one of these should be taken into account when no further information is available to con- strain the models. For the medium deep well, the additional stresses did not significantly improve model performance and it is concluded that they do not have to be taken into account for this well. For the deep well, model performance is improved by both stresses. The largest improvements are observed when the effect of groundwater extractions is considered in the model. For implemen- tation of these stresses, the entire simulation period should be used for calibration, or constraints have to be implemented to obtain realistic results.Water ResourcesWater ManagementCivil Engineering and Geoscience
Agreement between interview data and a self-administered questionnaire on dietary supplement use
No full textAgreement between interview data and a self-administered questionnaire on dietary supplement use. Dorant E, van den Brandt PA, Goldbohm RA, Hermus RJ, Sturmans F. Department of Epidemiology, University of Limburg, Maastricht. OBJECTIVE: To study the relative validity of an open-ended question on the consumption of dietary supplements in the preceding five-year period, incorporated in a self-administered questionnaire used in the NLCS, The Netherlands Cohort Study on diet and cancer (120,852 men and women aged 55-69 years). DESIGN: Questionnaire data were compared with reference information from three personal interviews carried out within a period of 10 months. SETTING AND SUBJECTS: A randomly selected subgroup (59 men and 50 women) of the cohort living in 12 municipalities in the eastern and western regions of The Netherlands. RESULTS AND CONCLUSIONS: The overall sensitivity of the questionnaire concerning the use of any dietary supplement was 65.9%, the specificity was 98.5%; kappa as measure of agreement was estimated at 0.69. A high percentage recall was observed among women, users of at least three types of dietary supplements, long-term supplement users and those in the oldest age group. Recall of intake of specific supplements ranged from 77.8% for garlic preparations to 11.8% for 'other' supplements. Estimates of consumption of specific supplements (garlic and vitamin preparations) may provide enough precision to correctly classify individuals as users or non-users of those supplement
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