8 research outputs found
A tell tale handshake
No full textAbstractMyotonic dystrophy is a group of inherited disorders called muscular dystrophies. Clinical presentation of this disease is characterised by progressive muscle weakness with myotonia, cataracts, infertility (in males) and cardiac conduction defects. We present a case of a 35 year old male with lung abscess, later diagnosed to be a case of myotonic dystrophy. Lung abscess is an uncommon presentation of this disease and has never been reported before
Author response image 1. Commercial Pgap2 antibody does not detect overexpressed or endogenous PGAP2.
No full textDesign of Bistable Arch-Profiles by Using Bilateral Relationship and Shape Optimization
No full textThe design of bistable arches is challenging due to their inherent nonlinear behaviour.It is known that the arch profiles of bistable arches in their two force-free equilibrium states are related to each other through a bilateral relationship.The closed-form analytical form of the bilateral relationship helps in designing the as-fabricated profile of the bistable arches when their toggled shape is completely specified.However, in certain cases, the arch profiles cannot be designed solely using the bilateral relationship.In this paper, we address such cases and present a design method to obtain arch-profiles using shape optimization in conjunction with the bilateral relationship.Such cases include: (1) arch-profiles that are partially specified in the first or/and second states; (2) arch-profiles that extremise the travel have a prescribed change in slope and have a specific ratio of travel between stable and unstable states.Towards this, the arch-profiles are represented using a set of finite variables corresponding to the mode weights of the basis set in which their shape is described.We formulate the optimization problem for each design case with the constraint to restrict the solutions in design space where the arches are bistable.After describing the procedure for numerically solving the optimization problem, design of arch-profiles using this method is illustrated through examples. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd
Intakes of nutrients and food categories in Canadian children and adolescents across levels of sugars intake: Cross-sectional analyses of the Canadian Community Health Survey 2015 Public Use Microdata File
Get PDFDietary recommendations to reduce sugars consumption may influence choices of sugars-containing foods and affect the intake of key micronutrients. We compared intakes of nutrients and food sources stratified by quintiles of total sugars in Canadian children (2-8y) and adolescents (9-13y, 14-18y) using 24-hour dietary recalls from the 2015 Canadian Community Health Survey-Nutrition. Energy intakes did not differ across quintiles of sugars intake. Those with lower sugars intakes (Q1/Q3) generally had higher protein, fat, sodium, niacin, folate and zinc and lower vitamin C compared to those with the highest sugars intakes (Q5). Q1 also had lower potassium but higher saturated fat compared to Q5. Further, Q1 generally had higher protein, fats and niacin compared to Q3, while children in Q3 had higher potassium and riboflavin and older adolescents had higher calcium and fibre. Q5 had highest intakes of multiple sugar-containing food categories (e.g. fruit, confectionary, milks, cakes/pies/pastries), with higher sugars-sweetened beverages in adolescents. Q3 had higher fruit, milks and fruit juice compared to Q1 and lower sugars/syrups/preserves, confectionary, and fruit juices compared to Q5. Certain nutrient-dense food sources of sugars (fruit, milks) may help increase key nutrients (potassium, calcium, fibre) in older adolescents with low sugars intakes. However, in those with the highest sugars intakes, nutrient-poor foods may displace nutrient-dense foods.
Novelty:
• Canadian children and adolescents with lower sugars intake have better intakes of some nutrients
• Energy intakes did not differ across sugars intake
• Older adolescents with mean intakes of total sugars had better intakes of some key nutrients (potassium, calcium, fibre)The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
The Second International Symposium on Tilapia in Aquaculture
Get PDFProceedings of the symposium held in 1987 in Bangkok, Thailand, by tilapia scientists to discuss strategies for future research and development in the tilapia industry worldwide. Contains 82 full papers, 17 poster abstracts and author and species indexes. The full papers were presented under 7 sessions: culture systems, management and production; pathology; genetics and reproduction; nutrition, physiology; biology and ecology; and economics and socioeconomics.Tilapia culture, Conferences
Sox17 and ß-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network
Get PDF© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Mukherjee, S., Chaturvedi, P., Rankin, S. A., Fish, M. B., Wlizla, M., Paraiso, K. D., MacDonald, M., Chen, X., Weirauch, M. T., Blitz, I. L., Cho, K. W. Y., & Zorn, A. M. Sox17 and ß-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network. Elife, 9, (2020): e58029, doi:10.7554/eLife.58029.Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive endoderm development, and yet, its genomic targets remain largely uncharacterized. Here, using genomic approaches and epistasis experiments, we define the Sox17-governed endoderm GRN in Xenopus gastrulae. We show that Sox17 functionally interacts with the canonical Wnt pathway to specify and pattern the endoderm while repressing alternative mesectoderm fates. Sox17 and β-catenin co-occupy hundreds of key enhancers. In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. Our findings establish Sox17 as a tissue-specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. Given the ubiquitous nature of Sox TFs and Wnt signaling, this mechanism has important implications across a diverse range of developmental and disease contexts.Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD073179)
Ken WY Cho
Aaron M Zorn
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK078392)
Aaron M Zorn
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD093363)
Aaron M Zor
The association between physical activity and neck and low back pain: a systematic review
Get PDFThe effect of physical activity on neck and low back pain is still controversial. No systematic review has been conducted on the association between daily physical activity and neck and low back pain. The objective of this study was to evaluate the association between physical activity and the incidence/prevalence of neck and low back pain. Publications were systematically searched from 1980 to June 2009 in several databases. The following key words were used: neck pain, back pain, physical activity, leisure time activity, daily activity, everyday activity, lifestyle activity, sedentary, and physical inactivity. A hand search of relevant journals was also carried out. Relevant studies were retrieved and assessed for methodological quality by two independent reviewers. The strength of the evidence was based on methodological quality and consistency of the results. Seventeen studies were included in this review, of which 13 were rated as high-quality studies. Of high-quality studies, there was limited evidence for no association between physical activity and neck pain in workers and strong evidence for no association in school children. Conflicting evidence was found for the association between physical activity and low back pain in both general population and school children. Literature with respect to the effect of physical activity on neck and low back pain was too heterogeneous and more research is needed before any final conclusion can be reached. © 2010 The Author(s)
