52 research outputs found
Retinal Remodeling: Concerns, Emerging Remedies, and Future Prospects
No full textDeafferentation results not only in sensory loss, but also in a variety of alterations in the postsynaptic circuitry. These alterations may have detrimental impact on potential treatment strategies. Progressive loss of photoreceptors in retinal degenerative diseases, such as retinitis pigmentosa and age-related macular degeneration, leads to several changes in the remnant retinal circuitry. Müller glial cells undergo hypertrophy and form a glial seal. The second- and third-order retinal neurons undergo morphological, biochemical and physiological alterations. A result of these alterations is that retinal ganglion cells (RGCs), the output neurons of the retina, become hyperactive and exhibit spontaneous, oscillatory bursts of spikes. This aberrant electrical activity degrades the signal-to-noise ratio in RGC responses, and thus the quality of information they transmit to the brain. These changes in the remnant retina, collectively termed retinal remodeling, pose challenges for genetic, cellular and bionic approaches to restore vision. It is therefore crucial to understand the nature of retinal remodeling, how it affects the ability of remnant retina to respond to novel therapeutic strategies, and how to ameliorate its effects. In this article, we discuss these topics, and suggest that the pathological state of the retinal output following photoreceptor loss is reversible, and therefore, amenable to restorative strategies
Multiple intra cardiac rhabdomyomas in neonate
No full textAn 18 day old neonate presented with tachypnea. Congenital heart disease was suspected and referred for Pediatric Cardiology opinion. 2D Echocardiography revealed multiple, intra cardiac, highly echogenic, well circumscribed, intramural and intra cavitary rhabdomyomas. There were no systemic manifestations of associated tuberous sclerosis. At present, surgical excision of rhabdomyoma was not indicated and hence child was advised regular follow up with echocardiography evaluation
Hammock mitral valve: A rare case report
No full textCongenital mitral stenosis is a relatively rare disorder comprising 0.2% of all congenital heart defects. Hammock mitral valve producing severe mitral stenosis is a rare variant of congenital mitral stenosis. We report a 2-year-old boy who had hammock mitral valve producing severe mitral stenosis with severe pulmonary artery hypertension. He underwent successful surgical repair. Post-surgery, the mitral valve opening was adequate without residual stenosis or regurgitation. Pulmonary artery pressure had normalized. Follow-up data showed he had significant clinical and echocardiography improvement. This is the first reported case of successful surgical repair done for hammock mitral valve from our institute
The MANVI product: MODIS (MAIAC) nadir-solar adjusted vegetation indices (EVI and NDVI) for South America
No full text<p><strong>Title: </strong>The MANVI product: MODIS (MAIAC) nadir-solar adjusted vegetation indices (EVI and NDVI) for South America.</p>
<p><strong>Authors:</strong> Dalagnol, Ricardo; Wagner, Fabien Hubert; Galvão, Lênio Soares; Aragão, Luiz Eduardo Oliveira e Cruz.</p>
<p><strong>Contact:</strong> Ricardo Dalagnol ([email protected])</p>
<p> </p>
<p><strong>Data:</strong> MODIS (MAIAC) EVI and NDVI indices</p>
<p><strong>Scale factor</strong>: 10000</p>
<p><strong>Coverage:</strong> South America land</p>
<p><strong>Time period:</strong> 2000 to 2018 (starting in 2000, Julian day 64) - <em>Note: 2018 might have a bias due to processing - I advise to use 2000-2017</em></p>
<p><strong>Spatial resolution:</strong> 1 km</p>
<p><strong>Temporal resolution:</strong> 16 days</p>
<p><strong>Coordinate reference system:</strong> geographic projection, datum WGS-84</p>
<p><strong>Processing details:</strong></p>
<ul>
<li>The original MODIS (MAIAC) data were described by Lyasputin et al. 2011 (<a href="https://doi.org/10.1029/2010JD014986">https://doi.org/10.1029/2010JD014986</a>). The daily MODIS (MAIAC) surface reflectance data from collection 6, acquired from Terra and Aqua satellites, are available from the MCD19A1 product (<a href="https://ladsweb.modaps.eosdis.nasa.gov/archive/allData/6/MCD19A1">https://ladsweb.modaps.eosdis.nasa.gov/archive/allData/6/MCD19A1</a>). The Bidirectional Reflectance Distribution Function (BRDF) model parameters are available from MCD19A3 product (<a href="https://ladsweb.modaps.eosdis.nasa.gov/archive/allData/6/MCD19A3">https://ladsweb.modaps.eosdis.nasa.gov/archive/allData/6/MCD19A3</a>)</li>
<li>The daily MCD19A1 data at 1 km spatial resolution were normalized using the BRDF parameters and Ross-Thick Li-Sparse (RTLS) model considering a fixed nadir view and a 45 deg. solar zenith angle using the parameters from the MCD19A3 product</li>
<li>The daily data were aggregated into 16-day composites by the pixel’s median. The 16-day composites always start from Day Of Year (DOY) 016 and end with DOY 352. Therefore, the remaining days from 352 to 365/366 were not used. This procedure was used to facilitate inter-annual comparisons</li>
<li>The tiles that cover the South America were mosaicked and re-projected from sinusoidal to geographic projection</li>
<li>The Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI) were calculated using standard formulas. The EVI parameters were: C1 = 6, C2 = 7.5, L = 1, G = 2.5</li>
</ul>
<p><strong>File(s) format:</strong></p>
<ul>
<li>Zip files for EVI and NDVI - one per year:
<ul>
<li>Inside them there are raster files with ".tif" format, one per 16-day window. The filename syntax is "maiac_southamerica_DATA_YYYYDOY.tif", where YYYY is the year (from 2000 to 2018), and the DOY is the Julian day of the last day of the composite window, i.e. YYYYDOY for January 2005 for DOY from 001 to 016 is 2005016, from DOY 017 to 032 is 2005032, etc.</li>
</ul>
</li>
<li>Csv files with the YYYYDOY and "real" dates for the time period</li>
</ul>
<p><strong>Code:</strong> <a href="https://github.com/ricds/maiac_processing">https://github.com/ricds/maiac_processing</a></p>
<p><strong>Acknowledgements:</strong> This work was funded by São Paulo Research Foundation – FAPESP, Brazil, grant 2015/22987-7. We thank NASA, and especially Yujie Wang and Alexei Lyapustin, for providing the freely available MODIS (MAIAC) data.</p>
<p> </p>
<p><strong>Dataset usage</strong>: This dataset is a product of the first author's PhD work and lots of hours of coding and patience. It is free to use, but if you use this dataset in your work, please make sure to properly cite the repository. We also welcome users to invite us for collaboration.</p>
<p> </p>
<p><strong>For use of this dataset please cite:</strong></p>
<p>Dalagnol, Ricardo; Wagner, Fabien Hubert; Galvão, Lênio Soares; Aragão, Luiz Eduardo Oliveira e Cruz. (2019). "The MANVI product: MODIS (MAIAC) nadir-solar adjusted vegetation indices (EVI and NDVI) for South America". (Version v1) [Data set]. Zenodo. <a href="https://doi.org/10.5281/zenodo.3159488">https://doi.org/10.5281/zenodo.3159488</a></p>
<p> </p>
<p><strong>More information: </strong>contact Ricardo Dalagnol ([email protected]). We also have the MODIS (MAIAC) BRDF-corrected bands 1-8, EVI, NDVI at 1 km with 16-day and monthly aggregation composites.</p>
Abraham Maslow’s Notion of Self- Actualization in Philip Roth’s American Pastoral
No full textThis article makes the argument more specifically on the humanistic psychology; a vibrant movement of the late 1950s; emphasizing the qualities, growth, need, creativity, and motivation of an individual. Philip Roth’s American Pastoral was an American classic, a novel of
American culture. It is not only a biography, but an intensive interpretation of the fall of American dream. The author demonstrates the American Pastoral from the humanistic point of view. This paper attempts to analyse the humanistic attitudes and values in the novel American Pastoral. The process from the basic to the being needs in the novel is being critically expressed within the framework of the humanistic psychology
Link stability estimation based on link connectivity changes in mobile ad-hoc networks
No full textDear Wang,
Re: Link Stability Estimation Based on Link Connectivity Changes in Mobile Ad-hoc Networks
I have not been able to assess if this is an author version peer-reviewed or is it an author version non peer reviewed. Could you please clarify this so I can proceed to add your paper to Spiral. Spiral digital repository only accept peer-reviewed papers.
30/11/12 author has confirmed peer reviewe
Comparative study of vitamin D3 levels in polycystic ovarian syndrome vs non-polycystic ovarian females
No full textBackground: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and has a strong genetic component with a prevalence of 6–10% in the general population. Metabolic disturbances are common in women suffering from PCOS: 30–40% have impaired glucose tolerance and IR with compensatory hyperinsulinemia, and as many as 10% will have type 2 diabetes mellitus by their fourth decade. Recently, vitamin D deficiency has been proposed as the possible missing link between IR and PCOS. Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. This study aims to estimate vitamin D3 levels in patients of polycystic ovarian disease and compare it with non PCOS females and to study correlation between Vitamin D3 levels and polycystic ovarian syndrome.
Methods: The present patient population case control study was carried out in Department of Obstetrics and Gynaecology of Jaipur Golden Hospital diagnosed involving cases of PCOS and controls of non PCOS (48 each) by random sampling method from September 2019 to June 2021. History, general examination, systemic examination and Vitamin D levels was taken for each patient.
Results: Mean vitamin D value of cases was 14.57±6.86 ng/ml and that in controls was 29.31±6.53 ng/ml. When we compared the mean vitamin D value of both the groups, there was statistically significant difference found between the two groups. . We found significant negative correlation found between vitamin D value with age and BMI.
Conclusions: Hypovitaminosis D is very common in PCOS patients and exacerbates the metabolic abnormalities. It is essential to screen all the PCOS patients for 25OHD deficiency and institute appropriate replacement therapy to prevent the adverse consequences
Detecting Traffic Conditions Model Based On Clustering Nodes Situations In VANET
No full textIn the last decade, cooperative vehicular network has been one of the most studied areas for developing the intelligent transportation systems (ITS). It is considered as an important approach to share the periodic traffic situations over vehicular ad hoc networks (VANETs) to improve efficiency and safety over the road. However, there are a number of issues in exchanging traffic data over high mobility of VANET, such as broadcast storms, hidden nodes and network instability.
This paper proposes a new model to detect the traffic conditions using clustering traffic situations that are gathered from the nodes (vehicles) in VANET. The model designs new principles of multi-level clustering to detect the traffic condition for road users. Our model (a) divides the situations of vehicles into clusters, (b) designs a set of metrics to get the correlations among vehicles and (c) detects the traffic condition in certain areas. These metrics are simulated using the network simulator environment (NS-3) to study the effectiveness of the model
Yeast 2 hybrid analysis shows 5 proteins interacting with Cpne4 vWAdomain.
No full text(A)A Gal4 based yeast two hybrid analysis on the adult mouse retina cDNA library with Cpne4 vWA domain as bait protein showed five positive interactions (blue colonies). (B) Gel image of colony PCR performed on the positive clones from the yeast two hybrid shows the corresponding interacting DNA sequences. The identity of these DNA sequences as confirmed by the Sanger sequencing followed by BLAST analysis are shown as labels on the lanes. (C-E) Sequence maps of the interacting peptides as identified by Sanger sequencing followed by BLAST analysis are shown for- Morn2 (C), Tox3 (D) and HCFC1 (E). The relative positions of the actual interacting region (light blue) are indicated on the respective protein (dark green) and the corresponding mRNA (red) or prey Gal4 DBD- cDNA (maroon) sequences, and the exons (gray) are also indicated on the respective maps.The black ruler with tick marks indicates 100 amino acids (upward ticks) or 100 base pairs (downward ticks).The various domains and regions are as labeled on the maps. E: Exon; MD: Morn domain; MCS: Multi cloning site; K: Kelch domain; FN III: Fibronectin type III domain; H: Cleavage site, Gal4 DBD: Gal4 DNA binding domain derived from prey library.</p
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