100,538 research outputs found
STRESS LAID THE WEAK SIGHTED ONES
No full textV diplomski nalogi so obravnavane otrokove pravice in pravice otrok s posebnimi potrebami, predvsem slepih in slabovidnih otrok.
Dana problematika je razdeljena na tri dele. V prvem delu se avtorica ukvarja z otrokovimi pravicami na splošno, pri čemer se osredotoči predvsem na mednarodnopravno ureditev otrokovih pravic.
V drugem delu se avtorica posveti otrokom s posebnimi potrebami. V prvi vrsti natančno razloži pojem »otrok s posebnimi potrebami« v različnih nacionalnih predpisih, navede pa tudi mednarodnopravne akte, ki to problematiko zadevajo. Posebej poudari pravice, ki izvirajo iz različnih nacionalnih predpisov.
Najobširneje so v zadnjem delu obravnavani slepi in slabovidni otroci. Podana je definicija slepote, zgodovinski razvoj slepih in razvoj vida pri otroku. Navedene so najpogostejše okvare vida pri otrocih, avtorica pa predstavi tudi različne pristope k obravnavi slepega in slabovidnega otroka. Predstavljeno je tudi eno izmed najpomembnejših vprašanj glede razvoja slepega oz. slabovidnega otroka, to je zgodnja celovita obravnava. Avtorica se na koncu dotakne tudi pravic slepih in slabovidnih študentov, nenazadnje pa opravi tudi intervju s slepim študentom in slabovidno študentko teologije ter ju priloži diplomski nalogi.This thesis discusses children´s rights and the rights of the children with special needs, in particular the blind and visually impaired children.
The issue in question is divided into three parts. In the first part, the author debates upon children´s rights in general, focusing mainly on the international legal regulation of children´s rights.
In the second part, the author deals with the children with special needs. Firstly, according to various national provisions she defines the term ´child with special needs´ in great detail. In addition, the author states international legal acts addressing this issue, and puts a special emphasis on the rights originating from different national provisions.
In the last part, the main focus of the author is on the blind and visually impaired children. She states the definition of blindness, a historical development of the blind and the development of a child´s sight. The most frequent children´s sight impairments are stated and the author also presents different approaches to deal with the blind and visually impaired child. The most important question according to the development of the blind or visually impaired children, i.e. the early overall treatment, is investigated as well. At the end, the author refers to the rights of the blind and visually impaired students by carrying out two interviews, added to this thesisone with a blind student and the second one with a visually impaired student of theology
The history of primary education in Kidričevo
No full textV okviru diplomske naloge z naslovom »Šolstvo v Kidričevem skozi čas« sem v uvodnem delu predstavila kraj Kidričevo kot občino in geografsko območje. Na kratko sem tudi opisala zgodovinski razvoj šolstva in zakonodaje na Slovenskem s poudarkom na vplivu cerkve v šolstvu in prvi slovenski knjigi.
Iz šolske kronike sem razbrala, da je bila leta 1950 ustanovljena prva osnovna šola v Strnišču. Na začetku so bili samo trije razredi, zato so poučevali tudi trije učitelji. V prvotnih načrtih je bila šola mišljena samo za prvi in drugi razred, ker pa je bilo toliko učencev, sta se odprla še dva dodatna oddelka tretjega in četrtega razreda. Zaradi pomanjkanja prostora je postajalo vedno bolj jasno, da bo šolo potrebno dograditi, kar se je leta 1963 tudi zgodilo. V letu 1991 je Ustava Republike Slovenije določila, da se šola financira z javnimi sredstvi in tako postane javni zavod. Zato je bilo to leto prelomno v življenju in ustvarjanju osnovnih šol nove države Slovenije. Eden izmed pomembnih dogodkov v Osnovni šoli Kidričevo in podružnični šoli Lovrenc je bila uvedba devetletke. Obe šoli sta s poskusnim uvajanjem devetletke začeli leta 2003.
Pomembno vlogo v kraju in šolanju pa je imela tudi Osnovna šola Lovrenc na Dravskem polju. O začetkih šole lahko govorimo že leta 1790. Prva kronika šole se začne šele leta 1962. Leta 1965 je šola zaradi priključitve dobila tudi nov naziv: Osnovna šola Kidričevo – Podružnična šola Lovrenc na Dravskem polju. Osnovna šola Kidričevo je postala centralna, šola v Lovrencu pa je izgubila še dva razreda. Učenci so tako lahko zaključili le štiri razrede in se nato pridružili učencem na Kidričevem.The introductory part of this diploma thesis entitled »The history of primary education in Kidričevo« comprises a presentation of Kidričevo as a municipality and a geographical area. This is followed by a short description of the history of education and legislation in Slovenia with an emphasis on the influence of the Church in education as well as in the first Slovenian book. Based on the information obtained from the school chronicles, I have established that the first elementary school in this area was built in 1950 in Strnišče. At the beginning, there were only three grades and therefore only three teachers. The school was originally planned for two gradeshowever, given the number of pupils, they opened two additional departments – the third and the fourth grade. Due to lack of space, the school had to be reconstructed, which was done in 1963. In 1991, the Constitution of the Republic of Slovenia stipulated that schools should be state-funded, hence becoming a public institute. This was a milestone in the history of primary education in the independent Republic of Slovenia. One of the most important events for the Kidričevo Primary School and its branch school Lovrenc was the 9-year programme, which was experimentally introduced in 2003. The Lovrenc na Dravskem polju Primary School also had a significant impact on the surrounding area and its local education. The foundation of this school can be dated back to 1790however, the first chronicles were written in 1962. In 1965, the school was renamed due to the annexation and is now called the Kidričevo Primary School – Lovrenc na Dravskem polju Branch School. The Kidričevo Primary School therefore became the central school, whereas the school in Lovrenc lost two more grades, meaning that the pupils could attend only first four grades and would later have to join the other pupils in Kidričevo
Large genomic deletion in bacteria Streptomyces rimosus using CRISPR-Cas9
No full textRazvoj celičnih tovarn na osnovi bakterij iz rodu Streptomyces je ključen za proizvodnjo novih in že poznanih biološko aktivnih učinkovin. S postopno delecijo večjih delov genoma lahko razvijemo učinkovito platformo za heterologno izražanje sekundarnih metabolitov. Klasične metode za manipulacije genoma v streptomicetah so zahtevne in časovno potratne. V tem delu, smo z uporabo CRISPR-Cas9 sistema izvedli delecijo genoma bakterije Streptomyces rimosus v velikosti 145 kb. Z bioinformacijsko analizo smo izbrali tarčno regijo genoma, ustrezne homologne regije in vodilne RNA. Z metodama PCR s prekrivanjem in SLiCE kloniranje smo sestavili plazmidni konstrukt za delecijo s CRISPR-Cas9. Konstrukt smo s konjugacijo vnesli v S. rimosus in testirali delecijo v pozitivnih klonih z metodo PCR in sekvenciranjem. Identificirali smo številne seve s pravilno delecijo izbranega fragmenta DNK v velikosti 145 kb.Developing a Streptomyces-based cell factory is key for the production of new or known biologically active compounds. With gradual deletion of large genomic regions one can develop an efficient platform for the heterologous expression of secondary metabolites. Gene manipulations of Streptomyces using classical approaches are demanding and time-consuming. In this work we used CRISPR-Cas9 to achieve a 145 kb genomic deletion in Streptomyces rimosus. With the use of bioinformatics we chose a target region with accompaning homologies and guide RNAs. We then used overlap PCR and SLiCE cloning to construct a plazmid for CRISPR-Cas9 driven deletion. The plasmid was introduced into S. rimosus with conjugation, then positive clones were tested for the deletion using PCR and sequencing. We have identified several isolates with correctly deleted DNA fragment of 145 kb in size
DIGITAL MEDIA AND BEAUTY IDEALS
No full textDiplomska naloga predstavlja tehnološke perspektive množičnih medijev in njihove zmožnosti reprezentacije idealne lepote. Vsebuje tudi razlago podob telesa in človeške identitete v potrošniški družbi glede na oglaševalske prakse. V analizi so predstavljene naslovnice revije Vogue, ki prikažejo, kako se je odnos človeka do teles spreminjal glede na razvoj množičnih medijev, reprezentacijskih tehnologij in potrošništva.The thesis describes technological perspectives of mass media and its abilities to present ideals in beauty. It contains explanations of body image and human identity in consumer society, considering the practices used in advertising. An analysis presents covers of Vogue magazine that show how human attitude towards the human body changed according to mass media development, representation technologies and consumerism
GoDec: Randomized low-rank & sparse matrix decomposition in noisy case
No full textLow-rank and sparse structures have been profoundly studied in matrix completion and compressed sensing. In this paper, we develop "Go Decomposition" (GoDec) to efficiently and robustly estimate the low-rank part L and the sparse part 5 of a matrix X = L + S + G with noise G. GoDec alternatively assigns the low-rank approximation of X - S to L and the sparse approximation of X - L to S. The algorithm can be significantly accelerated by bilateral random projections (BRP). We also propose GoDec for matrix completion as an important variant. We prove that the objective value ∥X - L - S∥F2 converges to a local minimum, while L and S linearly converge to local optimums. Theoretically, we analyze the influence of L, S and G to the asymptotic/convergence speeds in order to discover the robustness of GoDec. Empirical studies suggest the efficiency, robustness and effectiveness of GoDec comparing with representative matrix decomposition and completion tools, e.g., Robust PCA and OptSpace. Copyright 2011 by the author(s)/owner(s)
Promotion of fermented foods as part of public nutrition in slovenian kindergardens
No full textPrehrana in način življenja pomembno vplivata na naše zdravje in počutje. Zdrava prehrana je še posebej pomembna za otroke in mladostnike, saj je odraščanje obdobje intenzivnega fiziološkega, psihosocialnega in kognitivnega razvoja posameznika. Fermentirana živila v prvi vrsti ohranjajo in zagotavljajo raznolikost prehrane, hkrati pa tudi blagodejno učinkujejo na zdravje, pospešujejo prebavni trakt, izboljšujejo imunski sistem in zmanjšujejo simptome intolerance na laktozo. Metode: Raziskava temelji na kvantitativni metodologiji, in sicer na analizi zbranih prosto dostopnih jedilnikov v javnih vrtcih podravske in primorske regije. Uporabili smo namensko vzorčenje. Rezultati: Obstajajo statistično pomembne razlike zastopanosti posameznih fermentiranih živil v jedilnikih glede na regije, in sicer pri jogurtu t = - 4,596 (p < 0,001), skuti t = 3,618 (p < 0,001), kefirju t = - 3,451 (p = 0,001) in kislem zelju t = 2,798 (p = 0,005). Obstajajo pa tudi statistično pomembne razlike med pojavnostjo posameznih fermentiranih živil glede na letni čas pri kislem zelju t = - 3,677 (p < 0,001) in kisli repi t = - 2,081 (p = 0,038). Razprava in sklep: Ugotovili smo, da so fermentirana živila zastopana v jedilnikih javnih vrtcev v regijah, kljub temu da ne obstajajo jasna navodila oziroma smernice NIJZ. Potrebno jih je uvrstiti v prehranske piramide, ter okrepiti promocijo le teh pri otrocih in mladostnikih.Diet and lifestyle have a significant impact on our health and well-being. A healthy diet is especially important for children and adolescents, as growing up is a period of intense physiological, psychosocial and cognitive development of the individual. In addition to maintaining and providing a varied diet, fermented foods have a beneficial effect on health, speed up the digestive tract, improve the immune system and reduce the symptoms of lactose intolerance.Methods: The research is based on a quantitative methodology, namely the analysis of collected freely available menus in public kindergartens in the Podravska and Primorska regions. Dedicated sampling was used.Results: There are statistically significant differences in the representation of individual fermented foods in the menus according to regions, namely yogurt t = - 4,596 (p < 0.001), cottage cheese t = 3.618 (p < 0.001), kefir t = - 3.451 (p = 0.001) and sourcrout t = 2,798 (p = 0.005). However, there are also statistically significant differences between the incidence of individual fermented foods according to the season in sourcrout t = - 3.677 (p < 0.001) and sourturnipt t = - 2.081 (p = 0.038).Discussion: Fermented foods are represented in the menus of public kindergartens in the regions, despite the fact that there are no clear instructions or guidelines of the NIJZ.Conclusion: It is necessary to include fermented foods in the food pyramids and guidelines for healthy eating, and to strengthen their promotion in children and adolescents
Occupational exposure to MRI, risk assessment and protection measures
No full textUvod: Zaposleni, ki delajo v območju naprav za MR slikanje so izpostavljeni različnim oblikam elektromagnetnih polj (EMP), ki se razlikujejo glede na frekvenco in trajanje izpostavljenosti. Za omejitev poklicne izpostavljenosti in varstvo pred zdravstvenimi tveganji zaradi EMP so mednarodne organizacije in odbori izdali različna varnostna priporočila in smernice. Direktiva 2013/35/EU določa specifične mejne vrednosti izpostavljenosti in opozorilne vrednosti za preprečitev posrednih in neposrednih biofizikalnih učinkov na zdravje zaposlenih. Namen: Namen raziskave je bil ugotoviti izpostavljenost zaposlenih, ki opravljajo delo v območju naprav za MR slikanje ter rezultate meritev primerjati z mejnimi in opozorilnimi vrednostmi, ki jih določa direktiva 2013/35/EU. Metode dela: Meritve Bo polja smo izvedli z uporabo merilne naprave Metrolab THM 1176. Za meritve impulznih visokofrekvenčnih polj smo uporabili dva merilna postopka. Z merilno napravo SRM-3006 smo izvedli točkovne meritve impulznih VF EMP v času izvedbe kliničnega protokola. Istočasno smo izvajali še meritve z napravo Narda NBM-550 na fiksnem merilnem mestu. Meritve nizkofrekvenčnega gradientnega magnetnega polja smo izvedli z uporabo merilne naprave ELT 400, ki je bila preko analognega vmesnika priključena na osciloskop. Rezultati: Najvišja vrednost Bo polja v območju izven prostora z MR napravo je bila izmerjena na merilnem mestu št. 2 in je znašala 0,61 mT. Najvišja vrednost Bo polja znotraj območja z MR napravo je bila izmerjena na merilnem mestu št. 10, ki označuje vhod v odprtino naprave in je znašala 1000 mT. Analiza meritev je pokazala, da so bile izpeljane opozorilne vrednosti za dB/dt presežene pri meritvah, ki so bile izvedene v prostoru z MR napravo na merilnih mestih 29 (4,03 T/s) in Y (7,08 T/s). Najvišja vrednost električne poljske jakosti je znašala 22,92 V/m, kar predstavlja 37,57 % opozorilne vrednosti Direktive 2013/35/EU za frekvenčno območje 10-400 MHz. Razprava in zaključek: Na podlagi rezultatov meritev in naših ugotovitev lahko potrdimo, da je poklicna izpostavljenost med rutinskimi postopki na MR oddelku Onkološkega inštituta Ljubljana skladna z mejnimi in opozorilnimi vrednostmi Direktive 2013/35/EU.Introduction: Medical personnel working in the MRI environment are exposed to various forms of electromagnetic fields (EMF) that vary in frequency and duration of exposure. Many international organizations and committees have developed various safety guidelines to limit occupational exposure and provide protection against known adverse health effects of EMF. Directive 2013/35/EU defines specific exposure limit values and the action levels to prevent all known indirect and direct biophysical health effects caused by EMF. Purpose: The purpose of this paper was to assess the occupational exposure to EMF in MRI clinical environment and to verify its compliance with exposure limit values and action levels set by Directive 2013/35/EU. Methods: The measurements of the static magnetic field have been performed using Metrolab THM 1176 measuring device. Two exposure recording systems were used to assess exposure to high frequency RF fields. Spot measurements were performed using SRM-3006. Simultaneously we measured electric field strength of high frequency RF fields on a fixed grid using Narda NBM 550. Exposure to low frequency gradient magnetic fields involved a measuring system of a Narda ELT 400 that was connected to the oscilloscope via analogue output of the probe. Results: The peak value of the Bo fringe field in the area outside the room with the MRI scanner was measured at the measuring spot 2 (0,61 mT). The peak value of the Bo field inside the room with the MRI scanner reached 1000 mT and was measured at the measuring spot 10. The analysis of low frequency gradient magnetic field measurements showed that the derived action levels for dB/dt were exceeded in the proximity of the MRI device during ongoing clinical protocol at two measuring spots. Peak values of dB/dt measured at this two measuring spots reached 4,03 T/s (measuring spot 29) and 7,08 T/s (measuring spot Y). The peak incident electric field strength was measured at 22,92 V/m, which represents 37,57 % of the action value for the frequency range 10-400 MHz. Discussion and conclusion: Based on the results of the measurements and our findings, we can confirm that the occupational exposure during routine clinical procedures at the MRI department of the Oncology Institute of Ljubljana complies with the exposure limit values and action levels set by Directive 2013/35/EU
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Biomolecular condensation of the microtubule-associated protein tau.
No full textCells contain multiple compartments dedicated to the regulation and control of biochemical reactions. Cellular compartments that are not surrounded by membranes can rapidly form and dissolve in response to changes in the cellular environment. The physicochemical processes that underlie the formation of non-membrane-bound compartments in vivo are connected to liquid-liquid phase separation of proteins and nucleic acids in vitro. Recent evidence suggests that the protein tau, which plays an important role in Alzheimer's disease and other neurodegenerative disorders, phase separates in solution, forms tau phases with microtubules, and associates with phase-separated RNA-binding protein granules in cells. Here we review the experimental evidence that supports the ability of tau to phase separate in solution and form biomolecular condensates in cells. As for other disease-relevant proteins, the physiological and pathological functions of tau are tightly connected - through loss of normal function or gain of toxic function - and we therefore discuss how tau phase separation plays a role for both, and with respect to different cellular functions of tau
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