3,348 research outputs found
Agenten en de strijd tegen de concurrentie: buitenlandse maatschappijen op de Nederlandse markt (ca. 1850 tot ca. 1900)
No full textVerlossing, brand, hagel en glas: de ontwikkeling van de schadeverzekeringsmarkt (medio 17e eeuw- eind 19e eeuw)
No full textLaissez-faire en regulering: verzekeren in tijden van wereldoorlogen en crisis (c. 1900-1945)
No full textVan Antwerpen via Amsterdam tot Rotterdam: de opkomst en ontwikkeling van de verzekeringsmarkt in Nederland (ca. 1550-c. 1800)
No full textBeurtlijsten, zekere winsten en varende doodskisten: de invloed van de Nederlandsche Handel-Maatschappij op het Nederlandse verzekeringswezen (1824 tot ca. 1870)
No full textNatural Variation of the Circadian Clock in Neurospora
No full textMost living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.Advances in Genetics, Vol. 99
Corrigendum to “A generic multi-level framework for microscopic traffic simulation with automated vehicles in mixed traffic” [Transport. Res. Part C: Emerg. Technol. 110 (2020) 291–311] (Transportation Research Part C (2020) 110 (291–311), (S0968090X19304322), (10.1016/j.trc.2019.11.019))
No full textThe authors regret that a contributing author was missing from the list of authors. The complete list of authors should be: “S.C. Calvert, B. van Arem, & J. W. C. van Lint”. All are with Delft University of Technology, Department of Transport & Planning, The Netherlands updated as above. The authors would like to apologise for any inconvenience caused.Transport and Plannin
Towards the Holy Grail: combining system dynamics and discrete-event simulation in healthcare
No full textThe idea of combining discrete-event simulation and system dynamics has been a topic of debate in theoperations research community for over a decade. Many authors have considered the potential benefits ofsuch an approach from a methodological or practical standpoint. However, despite numerous examples ofmodels with both discrete and continuous parameters in the computer science and engineering literature,nobody in the OR field has yet succeeded in developing a genuinely hybrid approach which truly integratesthe philosophical approach and technical merits of both DES and SD in a single model. In this paperwe consider some of the reasons for this and describe two practical healthcare examples of combinedDES/SD models, which nevertheless fall short of the “holy grail” which has been so widely discussed inthe literature over the past decade
The Amsterdam Chamber of Insurance and Average: A New Phase in Formal Contract Enforcement (Late Sixteenth and Seventeenth Centuries)
No full textThere is an on-going debate among scholars from various disciplines about economic institutions and their impact on economic development. The case of the Amsterdam Chamber of Insurance is relevant to this discussion and in particular to the part that focuses on the nature and development of contract enforcement mechanisms. Marine insurance was introduced in Amsterdam in the mid-sixteenth century and soon the insurance industry developed into a prospering business. Its development was of great importance to the expansion of long-distance trade as it reduced the financial consequences of risks inherent to maritime trade. However, the new industry with its complex contracts was prone to misunderstandings, fraud and deception, creating the need for an independent, specialised court. The Chamber of Insurance was established as a generalised court, rather than a particularised court as was the case in cities that preceded Amsterdam's trade dominance. Why did the Amsterdam municipality choose to set up this court and what were the implications? A recently discovered Statute Book of the Chamber gives insight into why the Chamber was established, how it functioned within the setting of Europe's dominant trade centre and how it has affected the development of similar courts in the Netherlands. © 2013 The Author
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
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