1,720,964 research outputs found
Effect of total sleep deprivation on the dimensional complexity of the waking EEG
No full textStudy Objectives: Sleep deprivation can affect the waking EEG that may reflect information processing of the brain. We examined the effect of total sleep deprivation (TSD) on nonlinear dynamics of the waking EEG. Design: Paired-group design Setting: A sleep disorders laboratory in a hospital. Participants: Twenty healthy male volunteers Interventions: Waking EEG data were recorded from subjects with eyes dosed after (a) an 8-hour night's sleep and (b) TSD for 24 hours. The dimensional complexity (D2), as a nonlinear measure of complexity, of the EEG after a full night sleep were compared with those of the EEG after TSD. Measurements and Results: The sleep-deprived states had lower D2 values at three channels (P4, O2, and C3) than normal states. Conclusions: TSD results in the decrease of complexity in the brain, which may imply sub-optimal information processing of the cerebral cortex:We suggest that the investigation of the relation between nonlinear dynamics of the waking EEG induced by TSD and cognitive performance may offer fruitful clues for understanding the role of sleep and the effects of sleep deprivation on brain function.This research was supported by the G7-project from the
Ministry of Science and Technology and KOSEF basic science
project
The relationship Between Nonlinear Measures of EEG and Positive and Negative Symptoms in Schizophrenia
No full text
Effects of alcohol hangover on cytokine production in healthy subjects
No full textA hangover is the syndrome of physical and mental symptoms that occurs 8 to 16 h after alcohol consumption with a zero level of alcohol. The aim of the current study was to investigate the effects of the alcohol hangover on cytokine production in healthy subjects. The hangover state was defined as 13 h after drinking 1.5 g/kg of alcohol (blood alcohol level = 0). A venous blood sample was taken from 20 healthy adult men before consumption of alcohol and during the hangover state. Peripheral blood mononuclear cells were separated and stimulated with phytohemagglutinin. An enzyme-linked immunosorbent assay was used to measure the production of the following cytokines: interleukin (IL)-1beta, IL-4, IL-6, IL-10, IL-12, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha). We found that the concentrations of IL-10, IL-12, and IFN-gamma were significantly increased during the hangover state compared with the concentrations in normal conditions. These results support the suggestion that the dysregulated cytokine pathway (IL-10, IL-12, and IFN-gamma) is associated with the symptoms of hangovers. (C) 2003 Elsevier Inc. All rights reserved
Analysis of the spatiotemporal EEG pattern in Alzheimers disease
No full textWe present an analysis of the spatio-temporal EEG pattern in Alzheimer's disease. The method of analysis, called the Karhunen-Loeve method, was applied to 10 patients who were diagnosed as having Alzheimer's disease. The time-varying principal pattern of all 16 channels of the EEG pattern was observed. Compared with the controls the patients with Alzheimer's disease had significantly different noticeable primary patterns and average values of the eigenvector component in 5 channels. i.e., Fp1, T3, C3, O1, and P3. These results can be considered to be due to a change in the relative diffusive activity change of the brain corresponding to the Alzheimer's disease's pathologic variation in the brain and coincide with the results of previous studies
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