Neurofibromatosis type 1 (NF1), or von Recklinghausen’s disease, is an autosomal dominant condition with an incidence of 1:3000
and a prevalence of 1:4000 to 1:5000. It is caused by mutations
in the NF1 tumor suppressor gene, located on chromosome 17
(17q11.2), which encodes neurofibromin, a protein able to down regulate the Ras-Raf/MAPK signaling pathway that activates cell
proliferatio
No full text
