14 research outputs found
Reusing the abandoned Industrial Heritage for new functions: chance for a social and cultural valorization
No full textThe reusing of the abandoned Industrial Heritage is a great chance to realise a sustainable development for the district and the town that host it.
In this age, in which “urban regeneration” and “sustainable development” are some of the most important topic, the intervention to re-qualify and to reuse the abandoned industrial areas, inserting new functions able to satisfy the contemporary society’s needs, represents a chance to save ground from new buildings and, at the same time to produce new opportunities for the local social, economic and cultural development.
This paper illustrates the project to reuse and re-qualify the Taller de Herreria of the Maestranza Central di San Bernardo in Chile as public library, developed as final project of the Master in Building Engineering – Architecture of the University of Pavia, designed with the collaboration of the Universidad Central de Chile.
The project is the result of a relevant analysis and a deep synthesis about both the topic of the valorisation of the abandoned industrial heritage and the meaning of the libraries in the contemporary society; it is designed a solution that valorises the existing building, its great volumetric dimension and the rhythm of the structural arcade.
The soul of the project is the “cultural path” that leads to discover the contents (the library, the studying areas and the reading areas) and the building (Taller de Herreria and its volume); the visitors move in a volume that offers new perspective and partial view till a big underground space, where new functions are located in spaces that do not damage the majestic original image
Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells.
Get PDFBackgroundMesenchymal and amoeboid movements are two important mechanisms adopted by cancer cells to invade the surrounding environment. Mesenchymal movement depends on extracellular matrix protease activity, amoeboid movement on the RhoA-dependent kinase ROCK. Cancer cells can switch from one mechanism to the other in response to different stimuli, limiting the efficacy of antimetastatic therapies.Methodology and principal findingsWe investigated the acquisition and molecular regulation of the invasion capacity of neoplastically transformed human fibroblasts, which were able to induce sarcomas and metastases when injected into immunocompromised mice. We found that neoplastic transformation was associated with a change in cell morphology (from fibroblastic to polygonal), a reorganization of the actin cytoskeleton, a decrease in the expression of several matrix metalloproteases and increases in cell motility and invasiveness. In a three-dimensional environment, sarcomagenic cells showed a spherical morphology with cortical actin rings, suggesting a switch from mesenchymal to amoeboid movement. Accordingly, cell invasion decreased after treatment with the ROCK inhibitor Y27632, but not with the matrix protease inhibitor Ro 28-2653. The increased invasiveness of tumorigenic cells was associated with reduced expression of Rnd3 (also known as RhoE), a cellular inhibitor of ROCK. Indeed, ectopic Rnd3 expression reduced their invasive ability in vitro and their metastatic potential in vivo.ConclusionsThese results indicate that, during neoplastic transformation, cells of mesenchymal origin can switch from a mesenchymal mode of movement to an amoeboid one. In addition, they point to Rnd3 as a possible regulator of mesenchymal tumor cell invasion and to ROCK as a potential therapeutic target for sarcomas
2D Poisson sigma models with gauged vectorial supersymmetry
Get PDFIndexación: ScopusAbstract: In this note, we gauge the rigid vectorial supersymmetry of the two-dimensional Poisson sigma model presented in arXiv:1503.05625. We show that the consistency of the construction does not impose any further constraints on the differential Poisson algebra geometry than those required for the ungauged model. We conclude by proposing that the gauged model provides a first-quantized framework for higher spin gravity. © 2015, The Author(s).https://link-springer-com.recursosbiblioteca.unab.cl/article/10.1007/JHEP08(2015)04
Amitriptyline–perphenazine therapy for persistent idiopathic facial pain: translational perspectives from a retrospective study
No full textAbstract Background Persistent idiopathic facial pain (PIFP) can be challenging, both in its diagnosis, which appears to be purely exclusionary, and in its treatment, which currently lacks a gold standard. Amitriptyline is considered a first-line therapy, although not always effective. Recent insights into the role of dopamine in facial pain suggest that a novel therapeutic approach could target the dopamine system. Methods This study aimed to retrospectively evaluate the efficacy of treatment with amitriptyline–perphenazine association in patients with severe PIFP. Thirty-one patients were given a regimen dose of amitriptyline–perphenazine at dosages ranging between 10/2 and 20/4 mg and were then retrospectively analyzed. We evaluated the following outcomes, referred to the last week prior to follow-up visits: NRS score for pain intensity (minimum, maximum, and average), the number of attacks, and SF-36 questionnaire for quality of life. Comparisons were made between pre- and post-treatment. Results Thirty-one patients over 35 were screened. At baseline, average NRS was 5 ± 0.93 (CI 95%: 4.6–5.3), and the median number of breakthrough episodes over last week was 5 ± 1.57 (CI 95%: 4–6) with a maximum NRS = 9 ± 0.89 (CI 95%: 8–9). After treatment, average NRS was 4.1 ± 0.93 (CI 95%: 3.8–4.5; p < 0.001), maximum NRS was 6.1 ± 1.60 (CI 95%: 5.5–6.6), and the median number of attacks was 4 ± 0.99 (IC 95%: 3–4) (p < 0.001). Regarding SF-36 questionnaire, the most improved parameters were quality of life related to pain (25.89 ± 12.48 vs 31.19 ± 13.44; p < 0.001) and physical function (69.56 ± 17.84 vs 84.17 ± 20.99; p < 0.001). Conclusion Despite limitations, the pain scores, the frequency of the attacks, and quality of life were found to be significantly improved after treatment. Although results are not broad based given the small sample size, the combination of amitriptyline and perphenazine may be an effective and well-tolerated treatment in patients with PIFP. It is abundantly clear that dopaminergic pathways play a key role in pain modulation, yet the underlying mechanisms have not been fully understood, requiring further investigation
Vascular Disrupting Activity of Tubulin-Binding 1,5-Diaryl-1<i>H</i>-imidazoles
No full textHighly cytotoxic 1,5-diaryl-1H-imidazoles were studied to clarify the relationship between cytotoxicity and activity as vascular disrupting agents (VDA). All the compounds disorganized the tubulin cytoskeleton, affected endothelial cell morphology and capillary formation in vitro, and caused vessel shutdown and tumor necrosis in vivo, thus confirming their vascular disrupting properties. Nonetheless, the substitution patterns on the imidazole ring, responsible for greater interaction energy with tubulin and higher cytotoxicity, were not associated to greater vascular disrupting activity
Feasibility of Therapeutic Music Listening in Fibromyalgia: A Randomised Controlled Pilot Study
No full textBackground: Fibromyalgia patients can benefit from music approaches as complementary treatments. In the literature, it was shown that these interventions managed pain conditions as well as reduced complaints, increased relaxation, and improved moods. Objective: This study aimed at evaluating music therapy, in the form of therapeutic music listening, specifically for patients with fibromyalgia, to treat chronic pain by reducing pain perception, increasing well-being, and improving quality of life. Methods: Twenty-four patients with fibromyalgia were recruited to take part in this feasibility pilot study that adopted a between-subject and within-subject design. Participants were randomised into three groups: (1) standard care, (2) standard care plus preferred music listening, (3) standard care plus Melomics-Health music listening, composed by an algorithm. Participants in experimental groups listened to 30 min of music at home, twice a day for a month. Patients’ perceptions of changes following the listening, the intensity of pain and its interference in their lives, physical and mental well-being, and reported attitudes towards listening to music were evaluated respectively through the patients’ global impression of change, the brief pain inventory, the Short Form Healthy Survey-12, and the cognitive behavioural assessment-outcome evaluation. Results: The study showed that music listening can significantly affect mental well-being compared to no music. Moreover, the effects in the Melomics-Health group are maintained at follow-up. No significant effect on pain perception was noted. Conclusions: The study provides information supporting a possible role of music listening in improving well-being of patients with fibromyalgia. (PsycInfo Database Record (c) 2023 APA, all rights reserved
Abstract 3289: PTX-008, a dual inhibitor of angiogenesis and tumor cell proliferation, potentiates the antineoplastic activity of targeted therapies in human tumor models
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