1,721,018 research outputs found
Management of locally advanced basal cell carcinoma treated with sonidegib: The experience of an Italian reference hospital
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Rate of growth - a novel surrogate marker for high-risk cutaneous squamous cell carcinoma? A case report and review of the literature
Full text linkCutaneous squamous cell carcinoma (cSCC) is one of the most common nonmelanoma skin cancer worldwilde, with a more invasive growth pattern and higher potential to metastatize than basal cell carcinoma. Although several risk factors have been linked to a high metastatic potential of cSCC, no widely accepted classification system for this common subtype of cancer exists. Herein we report an emblematic case of rapidly growing and metastatic cSCC and discuss the rate of growth of the tumour (ROG) as novel prognostic high risk surrogate marke
Doxycycline, a widely used antibiotic in dermatology with a possible anti-inflammatory action against IL-6 in COVID-19 outbreak
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Topical dermocosmetics and acne vulgaris
No full textAcne is a highly common skin disease especially among teenagers. Modern acne treatments are based also on the use of moisturizers, cleansers and sunscreens. In choosing the right cleanser, it is important to consider some aspects: the interaction between skin type and the cleanser, the optimal time and method of cleaning and the cosmetic perception of the patient. The aim of our review is to highlight the importance of choosing the most suitable topical dermocosmetics for the different skin types, as well as the most effective timing and method to combine dermocosmetics with the standard acne treatment. A search in literature for selected key words was performed using PubMed. Additional papers were identified based on author expertise. Treatment of acne patients should include education for proper daily skin hygiene, including protection from environmental damage. However, given the low number of clinical studies on cleansers, it is difficult to make reliable recommendations. The correct choice and use of topical dermocosmetics are fundamental in the management of acne patients. Daily use of moisturizers, cleansers and sunscreens can reduce both inflammatory and non-inflammatory acne lesion counts and may be helpful for acne treatment if combined with specific drugs
A case of disfiguring primary cutaneous squamous cell carcinoma of the nasal tip
No full textWe describe a 63‐year‐old Caucasian man who presented to our skin cancer unit because of a rapidly growing, ulcerated plaque on his nose, which he had first noticed 3 months previously. The ulcerated plaque involved the whole tip of the nose, which resulted in a significant disfigurement (Fig. 1). His personal and family medical history was unremarkable. He denied any type of trauma, chronic inflammation or infection at this site. On a physical examination, the lesion appeared as an indurated, infiltrating, well‐defined protruding ulcer with elevated borders, measuring 3.0 × 3.0 cm. A punch biopsy was taken and histopathology was interpreted as a well‐differentiated squamous cell carcinoma (SCC). Three weeks later, the tumour was surgically excised with a 6‐mm safety margin. Based on the histopathological examination of the whole tumour, the initial diagnosis of a well‐differentiated SCC was reversed into that of a poorly differentiated subtype without neural invasion or infiltration into the sub‐cutis. All resection margins were tumour‐free. There were no clinical signs of node involvement and further imaging, including a computed tomography of the head and neck and ultrasound of the cervical lymph nodes as well as a radiography of the chest showed no evidence of metastasis. The surgical defect was finally closed by rhinoplasty with an aesthetically and functionally good outcome. At the latest follow up of 3 years after the initial diagnosis the patient had no recurrence or metastases
Management of patients with melanoma and non-melanoma skin cancers in the coronavirus disease 2019 era
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A portable hybrid hydrogen fuel cell-battery power unit for wireless sensor network
No full textHydrogen fuel cells are considered one of the most promising alternatives to batteries, because of their higher energy density and they are not affected by issues related to self-discharge. Fuel cells are very attractive for devices with long lifetime requirements. Unfortunately, fuel cells suffer from slow dynamic response to load changes and require active gas flow control. These issues have not been previously addressed for portable systems and small scale fuel-cells. This work presents a hybrid hydrogen micro fuel cell/ Li-Ion battery power unit for embedded systems and wireless sensor networks which tackles these issues. The power system is microcontroller-based and it provides a driver circuits to control the hydrogen flow closing and opening an electro-valve certified for hydrogen gas. We first describe the fuel cell implementation we characterize its power delivery capability. Next, we present the architecture of the developed prototype for the power unit and the fuel flow control system. Finally an evaluation of the performance during Li-Ion battery recharges is presented. The behaviour of hybrid system is examined and tested and the experimental results show the high efficiency (around 85%) of the proposed solution. A 1000mAh Li-Ion battery is re-charged with 11liters of hydrogen in around 2 hours
Clinical and dermoscopic characterization of pediatric Spitz nevi of the ear
No full textSpitz nevi of special sites, such as the ear, appear rarely and pose a challenge with worrisome clinical, dermoscopic, or histopathological features. Our aim was to evaluate the morphological findings of a series of Spitz nevi of the ear in order to obtain more knowledge about their clinical-dermoscopic patterns. Of a total of six cases, three main dermoscopic structures were found: pseudonetwork, structureless areas, and cobblestone pattern. Our preliminary findings suggest that dermoscopy may be helpful in improving the diagnostic accuracy of Spitz nevus of the ear and minimize surgery in a sensitive location
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