887 research outputs found
Management of care transition and hospital discharge
No full textCurrent demographic and epidemiological trends highlight a growing task in surgical departments by elderly patients, characterized by high prevalence of comorbidity, complexity, and functional disability. Of consequence, discharge of an elderly patient must be considered in a new cultural perspective and should be imagined as a well-structured process starting from admission to surgical department and finishing with the patient discharge in a setting able to support her/him in the best possible way. The lack of a suitable discharge planning and of a proper transition program in the elderly subjects increases the risk of quick re-admission and may negatively affect the functional and the status quality of life of patients and caregivers. To reduce the risk of negative outcome it is essential a hospital organization dedicated to the discharge of frail older patients considering: (1) adequate attention to assess the comprehensive clinical/social/care conditions; (2) respect of the expectations of the patient and her/his relatives; (3) formalization of institutional roles or teams designated to the planning and coordination of discharge; (4) good knowledge of management programs of transitional care, and (5) strong communication/information ability in patients transition between hospital, home care and community settings
Frontier on Alzheimer’s Disease
No full textAlthough substantial progress has been made in the last two decades, there are still important unfilled gaps in the understanding of the pathomechanism of Alzheimer’s disease (AD) [...
Recent developments in the knowledge of inherietd forms of hypercholesterolemia. The familial recessive hypercholesterolemia
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A high frequency of length polymorphisms in repeated sequences adjacent to Alu sequences
No full textWe describe a new class of DNA length polymorphism that is due to a variation in the number of tandem repeats associated with Alu sequences (Alu sequence-related polymorphisms). The polymerase chain reaction was used to selectively amplify a (TTA)(n) repeat identified in the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase gene from genomic DNA of 41 human subjects, and the size of the amplified products was determined by gel electrophoresis. Seven alleles were found that differed in size by integrals of three nucleotides. The allele frequencies ranged from 1.5% to 52%, and the overall heterozygosity index was 62%. The polymorphic TTA repeat was located adjacent to a repetitive sequence of the Alu family. A homology search of human genomic DNA sequences for the trinucleotide TTA (at least five members in length) revealed tandem repeats in six other genes. Three of the six (TTA)(n) repeats were located adjacent to Alu sequences, and two of the three (in the genes for β-tubulin and interleukin-1α) were found to be polymorphic in length. Tandemly repetitive sequences found in association with Alu sequence may be frequent sites of length polymorphism that can be used as genetic markers for gene mapping or linkage analysis
TETRANUCLEOTIDE LENGTH POLYMORPHISM 5' OF THE ALPHA(2)-MACROGLOBULIN RECEPTOR (A2MR)/LDL RECEPTOR-RELATED PROTEIN (LRP) GENE
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Re-appraisal of cardiovascular risk prediction in healthy older people: Have you ever considered the added value of patient-perception of health status?
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