120 research outputs found
The Renaissance and the universal surgeon: Giovanni Andrea Della Croce, a master of traumatology.
No full textAll the medical knowledge of all time in one book, the universal and perfect manual for the Renaissance surgeon, and the man who wrote it. This paper depicts the life and works of Giovanni Andrea della Croce, a 16th Century physician and surgeon, who, endowed with true spirit of Renaissance humanism, wanted to teach and share all his medical knowledge through his opus magnum, titled "Universal Surgery Complete with All the Relevant Parts for the Optimum Surgeon". An extraordinary book which truly represents a defining moment and a founding stone for traumatology, written by a lesser known historical personality, but nonetheless the Renaissance Master of Traumatology
Do different physicians' panels reach similar conclusions? A case study on practice guidelines for limited surgery in breast cancer
No full textDo different physicians' panels reach similar conclusions? A case study on practice guidelines for limited surgery in breast cancer
No full textUtilization of Impedance Spectroscopy to investigate the self-assembly behavior of amphiphiles soluble in supercritical carbon dioxide: preliminary results
No full textA mixture of CO2, water, methyl orange (MO) and Dynol 604 surfactant was analyzed at 309K and 20MPa simultaneously by impedance and
UV–vis spectroscopy. A plot of the static dielectric constant as a function of the surfactant concentration was obtained using a suitable equivalent
circuit to elaborate impedance data. Experimental points can be fitted by two different straight lines whose intersection occurs at about 0.13%
(w/w) concentration of Dynol. When the surfactant concentration crossed the aforementioned value, a peak was detectable in the UV–vis spectrum
at a wavelength range corresponding to the absorption of MO; absorbance of the peak increased with the surfactant concentration. As it has been
already shown that Dynol 604 stabilizes microemulsions of water in CO2, these preliminary results suggest that measurements of dielectric constant
can be used to detect micellization of amphiphiles soluble in supercritical CO2
Art in Science: Giovanni Paolo Mascagni and the Art of Anatomy
No full textFor centuries, the human body was considered an inviolable treasure chest, as religious authorities largely restricted anatomical dissections. The first scientists to attempt these kinds of studies often were forced to perform their research in secret, far from the
eyes of the clergy. It was only at the beginning of the 13th century that we find the first traces of public anatomical dissection performed by Mondino de’ Liuzzi, professor of anatomy at the University of Bologna [2]. From that moment on, radical new ideas (both religious and scientific) were proposed. Dissections became a common method to teach human anatomy throughout Europe
Impact of calcific mitral stenosis on survival in patients with aortic stenosis treated with TAVR
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GSK3 beta: a key regulator of oxidative stress in 3D-cultures of osteoarthritic chondrocytes
No full textCommentary on : New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft by El-chami et.al
No full textAssessment of the Severity of Paravalvular Regurgitation and its Role on Survival After Transcatheter Aortic Valve Replacement
No full textBackground: To evaluate the impact of various measurements of paravalvular regurgitation (PVR) on survival after transcatheter aortic valve replacement (TAVR). PVR can be difficult to grade and both its incidence and impact on survival may be decreasing as TAVR evolves. Methods: This retrospective study included 911 patients undergoing TAVR in two institutions. PVR was graded according to the 3-grade scheme proposed by the guidelines (PVR grade), and subsequently grade 2 and 3, and grade 0 and 1 were lumped together. PVR was also graded as a composite score (PVR score), based on 6 commonly used metrics. PVR grade, PVR score and its six individual components were tested against the risk of both 1-year and longer term mortality after TAVR. Results: Patients with moderate/severe PVR had a higher Society of Thoracic Sugeons (STS) score, higher levels of serum creatinine and larger left atria compared to patients with none/mild PVR. Moderate/severe PVR was more frequent with self-expandable and larger valves. After adjusting for American College of Cardiology (ACC) TAVR risk score, neither PVR grade, PVR score nor its six components were associated with an increased risk of mortality at 1-year (severe PVR adjusted HR: 0.75, 95% Confidence Interval [CI]: 0.19, 3.01, p = 0.50). However, intervention for clinically severe PVR increased the risk of mortality by more than 7-fold (adjusted hazard ratio [HR]: 7.6, 95% CI: 2.4, 23.5, p Conclusions: In the contemporary era, moderate-severe PVR is uncommon. However, re-intervention for PVR portends a poor prognosis. This highlights the crucial importance of clinical judgment over imaging alone.</p
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