1,711 research outputs found
“Transferrins, nitric oxide and cytokines: complex responses to Marek’s Disease Virus reinfection in a chicken lymphoblastoid cell line.”
“Ovotransferrin protects Chicken Embryo Fibroblasts from Marek Disease Virus infection”.
“Ossido di azoto, transferrine e citochine: una risposta articolata all’infezione da virus della malattia di marek“.
“Attività antivirale della ovotransferrina contro l’alphaherpesvirus aviario responsabile della Malattia di Marek”.
“Attività antivirale di transferrine e studi preliminari sul loro ruolo proapototico in cellule infettate dall’alphaherpesvirus aviario responsabile della Malattia di Marek (MDV)”.
“Nitrossido e transferrine nell’infezione da parte del Virus della Malattia di Marek (MDV)”
Antiviral activity of ovotransferrin derived peptides
Ovotransferrin and lactoferrin are iron-binding proteins with antiviral and antibacterial activities related to natural immunity,
showing marked sequence and structural homologies. The antiviral activity of two hen ovotransferrin fragments DQKDEYELL
(hOtrf219–227) and KDLLFK (hOtrf269–301 and hOtrf633–638) towards Mareks disease virus infection of chicken embryo fibroblasts
is reported here. These fragments have sequence homology with two bovine lactoferrin fragments with antiviral activity towards
herpes simplex virus, suggesting that these fragments could have a role for the exploitation of the antiviral activity of the intact proteins
towards herpes viruses. NMR analysis showed that these peptides, chemically synthetized, did not possess any favourite conformation
in solution, indicating that both the aminoacid sequence and the conformation they display in the intact protein are
essential for the antiviral activity
“Apoptosis in cocoltures of tumor cell lines and NK cells from chicken peripheral blood”.
Cytogenetic stability of chicken T-cell line transformed with Marek's disease virus: atomic force microscope, a new tool for investigation
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