620 research outputs found
Pulmonary nodules and mini-invasive lung resection: do we have the right “tool” for their intraoperative localization?
No full textDSC study of crystallinity changes of naproxen in ground mixtures with linear maltooligomers
No full textDifferential scanning calorimetry has been applied to the analysis of cogrinding-induced crystallinity changes of naproxen in binary mixtures with linear maltooligomers. Factors which play a role in the amorphization process were the mixture composition, the duration of mechanical treatment and the degree of polymerization of the carrier. Maltopentaose was about as active as amorphous hydroxypropyl alpha- and beta-cyclodextrin MS 0.6, while maltotetraose displayed practically the same amorphizing capacity as native alpha- and beta-cyclodextrin. The melting peak temperature of naproxen was substantially unaltered by cogrinding with maltooligomers, while it considerably dropped in coground mixtures with cyclodextrin derivatives. This might be due to formation of a true inclusion complex in the solid state
Large-ring cyclodextrins: physical chemical characterization and potential use in drug delivery
No full textInvestigation of physico-chemical properties of delta-, epsilon- and iota-cyclodextrins by means of thermal analysis (DSC and TG) supported by X-Ray powder diffraction has been done. Studies on dehydration-rehydration behaviour demonstrated that dehydrated delta-cyclodextrin may transform under controlled humidity conditions to a heptahydrate and dehydrated epsilon-cyclodextrin to an amorphous form, while the dehydrated iota-cyclodextrin reverted to the starting nonhydrate crystal form
Thermoanalytical characterization of pseudopolymorphs of sulphadimidine and sulphadimidine-trimethoprim molecular complexes
No full textIn recrystallization experiments of sulphadimidine from water, dioxane and their mixtures aimed at preparing the unstable
hydrate, a non-stoichiometric solvate with dioxane and a pseudopolymorph with similar X-ray powder diffraction and infrared absorption properties but different thermal behaviour (DSC, TG) were isolated. In co-crystallization experiments of trimethoprim and sulphadimidine, a monohydrate of the respective 1 : 2 molecular complex and a methanol solvate of the equimolecular complex were obtained from aqueous ethanol and anhydrous methanol, respectively. The thermal stability of both pseudopolymorphic complexes is re ̄ected by the high DSC and TG onset temperatures of solvent escape from the crystal lattice (Te=163 °C and Te = 144 °C, respectively, for water and methanol) and is consistent with the important role of water in the hydrated crystal packing and the very strong hydrogen-bonding interaction of methanol with a sulphonamido oxygen atom in the methanol solvate crystal
Correction to: Pediatric elbow arthroscopy: clinical outcomes and complications after long-term follow-up (Journal of Orthopaedics and Traumatology, (2021), 22, 1, (55), 10.1186/s10195-021-00619-2)
No full textFollowing publication of the original article [1], the authors identified an error in the author names. The given name and family name were erroneously transposed. The incorrect author names: Micheloni Gian Mario, Tarallo Luigi, Negri Alberto, Giorgini Andrea, Merolla Giovanni and Porcellini Giuseppe. The correct author names: Gian Mario Micheloni, Luigi Tarallo, Alberto Negri, Andrea Giorgini, Giovanni Merolla, Giuseppe Porcellini. The author group has been updated above and the original article [1] has been corrected
Isolated tension pneumoperitoneum following endobronchial ultrasound-guided transbronchial needle aspiration complicated by cardiac peri-arrest: A case report
No full textTransbronchial needle aspiration under endobronchial ultrasound guidance (EBUS-TBNA) is recommended for the diagnosis and staging of lung cancer. Major complications following EBUS-TBNA are uncommon. We report a case of isolated tension pneumoperitoneum following EBUS-TBNA under deep sedation in an 80-year-old male patient affected by a right hilar mass suspicious for lung cancer. At the end of the procedure, the patient suddenly manifested desaturation, severe bradycardia and hypotension, and abdominal distension. After resuscitation, in the suspect of intraperitoneal free air, needle decompression led to respiratory and hemodynamic improvement. A total body CT-scan showed isolated pneumoperitoneum without signs of gastrointestinal perforation, confirmed by a subsequent upper digestive contrast study. The patient recovered well without the need of surgical exploration. Isolated tension pneumoperitoneum can be an exceptional complication of EBUS-TBNA; a conservative treatment can avoid unnecessary surgery in the absence of peritonism
Thermal behaviour and phase transitions of cyclomaltodecaose (epsilon cyclodextrin)
No full textThe thermal behaviour of large-ring cyclodextrins (water loss followed by melting with decomposition at temperatures higher 250 °C) resembles that of alfa-, beta- and gamma-cyclodextrins. The shape of DSC dehydration endotherm makes it possible to descriminate betweena epsilon cyclodextrin .19 H2O and delta cyclodextrin . 13,75 H2O
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