198 research outputs found
Are there new relevant therapeutic endpoints in the modern era of the BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia?
No full textALTO-ADRIATICO VASES FROM ISSA
No full textU ovom prilogu obrađuju se slikane vaze tipa"Alto-Adriatico" otkrivene na nekropolama antičke Isse, a koje pripadaju kraju 4. i početku 3. st. stare ere. Autor se osvrće i na ostale nalaze ovih vaza na sjevernom i srednjem Jadranu te donosi sva relevantna mišljenja o ovoj produkciji. Posebno se bavi datacijom ovih vaza te zastupa mišljenje da se one nisu tako dugo proizvodile kako se smatra u dosadašnjoj literaturi.Na kraju je dan katalog vaza.In this paper 10 oinohoai of the Alto-Adriatico style from Issa are published. A short history and bibliography of the study of these vases is presented at the beginning of the paper. A distribution map of these vases which are found on 10 sites is given (fig. 1) and also a quantitative figure (fig. 2) of shapes and number of vases found on sites. All together15 shapes and 373 vases of Alto-Adriatico style are known. From this it is evident that the production and distribution is restricted to the north and central Adriatic and that the concentration is in Spina (180) and Adria (11O). All the known vases are found in graves what strongly suggests their funerary function.The vases from Issa could be dated in the late 4th cent. B. C. and probably in the very early 3rd cent. B.C. In Issa they are found on 3 cemeteries but all the vases are similar in shape, decoration and fabric. It could be that these vases came from Spina or from Adria (?) together with grain or ores which the Isseians needed. The fact that the number of Alto-Adriatico vases is very small and that not many painters (hands) can be distinguished made the author think that the production did not lastlong, i.e. from the mid 4th cent. B. C. to the early 3rd. cent. B. C.Although the vases belong to the Hellenistic period they are not Hellenistic but an late provincial offspring of redfigured vases of the classical period.At the end of the paper a detailed catalogue of the published vases is given
Polyphony and the anxiety of influence in the fiction of Henry James
No full textJames's fiction, especially in the Middle Phase, centres
on the figure of the artist and is characterized by, the two
interrelated aspects which previous criticism has largely
overlooked: the Bakhtinian 'polyphonic' -creation of
'author-thinkers'; and the conflict between ephebes and
precursors, for which Harold-Bloom's concept of 'the-anxiety of
influence' is the most illuminating model. Polyphony is the
narrative mode, and influence is the intra-artistic, theme.
These, as the Introduction to the thesis makes clear, are
rehearsed in James's inaugural novel, Roderick Hudson. Rowland
Mallet is an author-thinker, and his failure is caused by
authorial limitations. His monologism -is impaired by his
mistaking empathy for the authorial sympathy. Likewise,
Hudson's failure does not arise from a mercurial temperament,
but from a polyphonic shortcoming: not possessing the power of
fiction to contain the fiction of power in, his mentor. And the
relationships among the three artists - Gloriani, Hudson and
Singleton - perfectly exemplify the Bloomian-theme. It is these
two concepts, polyphony and influence, which are the major
preoccupation in the Middle Phase; as, the works chosen
demonstrate. These are a novella, a novel, and a number of
short stories all of which have been unjustifiably neglected.
Chapter One, on The Aspern Papers, argues that Tina Bordereau,
far from being, the artless victim seen by many critics,
actually challenges and defeats the narrator by the very form
of her narrative. Her 'realist' discourse undermines his
language of 'romance', and shows up its internal unstability.
Chapter Two is an extensive study of the critical reception of
The Tragic Muse. The most common areas of critical attention
have been its contemporary topicality, its relation to previous
novels on similar themes, and the possible genealogy of Gabriel
Nash. Those have all missed the core of the work. - Chapter Three
demonstrates how polyphony and the anxiety of influence make
the novel what it really is. Influence arises from the
juxtaposition of, and the wrestling between, artistic ephebes
and their precursors (Nick and Nash,, Miriam and Madame Carre).
The dialogic quality defined by Bakhtin is crucial to the
proper, and even-handed, characterization of all, the conflicts
in the novel. And since most of James's tales in the eighties
and nineties -are about 'masters - and acolytes, the anxiety of
influence remains central. Chapter Four is a study of 'The
Author of Beltraffiol' and 'The Lesson of the Master'. Again the
characters' manipulations are a crucial focus in a way that
G6rard Genette's terminology helps to illuminate. The fact that
the ephebe is the author-thinker emphasizes the inextricability
of the Bakhtinian and the Bloomian in James. Just as
polyphony offers a different focus for explicating the poetics
of James's fiction; so the ephebal conflict provides the basis
for a fresh perception of James's own artistic struggle
Menin inhibition with revumenib for KMT2A-rearranged relapsed or refractory acute leukemia (AUGMENT-101)
No full textPURPOSE: Revumenib, an oral, small molecule inhibitor of the menin-lysine methyltransferase 2A (KMT2A) interaction, showed promising efficacy and safety in a phase I study of heavily pretreated patients with
METHODS: AUGMENT-101 is a phase I/II, open-label, dose-escalation and expansion study of revumenib conducted across 22 clinical sites in five countries (ClinicalTrials.gov identifier: NCT04065399). We report results from the phase II, registration-enabling portion. Individuals age ≥30 days with R/R
RESULTS: From October 1, 2021, to July 24, 2023, N = 94 patients (median [range] age, 37 [1.3-75] years) were treated. Grade ≥3 adverse events included febrile neutropenia (37.2%), differentiation syndrome (16.0%), and QTc prolongation (13.8%). In the efficacy-evaluable patients (n = 57), the CR + CRh rate was 22.8% (95% CI, 12.7 to 35.8), exceeding the null hypothesis of 10% (
CONCLUSION: Revumenib led to high remission rates with a predictable safety profile in R/
Securities clearance and settlement systems - a guide to best practices
No full textAs an essential part of a nation's financial sector infrastructure, securities clearance, and settlement systems must be closely integrated with national payment systems, so that safety, soundness, certainty, and efficiency can be achieved at a cost acceptable to all participants. Central banks have paid considerable attention to payment systems, but securities clearance, and settlement systems have only recently been subjected to rigorous assessment. The Western Hemisphere Payments and Securities Clearance and Settlement Initiative (WHI), led by the World Bank, and in cooperation with the Centro de Estudios Monetarios Latinoamericanos (CEMLA), gave the authors a unique opportunity to observe how various countries in Latin America, and the Caribbean undertake securities clearance, and settlement. To do so, the authors developed a practical, and implementable assessment methodology, covering key issues that affect the quality of such systems. In this paper they discuss the objectives, scope, and content of a typical securities system, identify the elements that influence the system's quality, and show how their assessment methodology works. They focus on the development of core principles, and minimum standards for integrated systems of payments, and securities clearance and settlement. Their paper fills a gap by providing an evaluation tool for assessors of such systems, especially those who must assess evolving systems in developing, and transition economies. Essentially, an assessment involves a structured analysis to answer four related questions: 1) What are the objective, and scope of a securities clearance and settlement system? 2) Who are the participants, what roles do they play, and what expectations do they have? 3) What procedures are required to satisfy the participants'needs? 4) What inherent risks are involved, and how can they be mitigated at an acceptable cost?Environmental Economics&Policies,Payment Systems&Infrastructure,Financial Intermediation,International Terrorism&Counterterrorism,Securities Markets Policy&Regulation,Financial Intermediation,Environmental Economics&Policies,Settlement of Investment Disputes,Payment Systems&Infrastructure,Insurance&Risk Mitigation
Czech Social Reform/Non-reform: Routes, Actors and Problems
No full textIn this contribution, the author first considers the characteristics of the Czechoslovak communist welfare state and its theoretical alternatives. Throughout the reform process, dependency on both corporatist and socialist regimes won out, while residualist efforts were promoted in the beginning, but were later held back. The author then considers the possible actors involved in social reforms. In this respect, when proceeding from a general to a more concrete level, thought should first be devoted to the social classes and their ideologies, and second to political parties and their leaders. The author goes on to summarise the particular problems and traps in individual sections of the Czech social system. While no objection to decent standards of social protection and health care could be raised, the poor efficiency of their achievement should evoke concern. The author concludes by reflecting on the possible specificities of Czech social reform in comparison with the other countries undergoing reform and the EU. The current lethargy of the Czech welfare system corresponds to a “frozen edifice”, just as in most Western countries. However, such stagnation is apparently acceptable to both the politicians (who mask it in reformist rhetoric) and the population (which learned to master taking advantage of the generous welfare state) and thus is basically sustainable in the long run.social policy, social reforms, Czech Republic
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia
No full textTargeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue functio
Corrigendum to “Exploring the potential of BBNCo glasses: Physical, optical, and radiation shielding analysis” [Opt. Mater. 142 (2023) 113976] (Optical Materials (2023) 142, (S0925346723005487), (10.1016/j.optmat.2023.113976))
No full textThe authors regret M.A.M. Uosifa, Shams A.M. Issab, c, A.S. Abouhaswad,e, A.M.A. Mostafaa, Ali Attaa, Hesham M.H. Zakalyc,f,g,*** > aPhysics Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia bDepartment of Physics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia cPhysics Department, Faculty of Science, Al-Azhar University, Assiut, 71452, Egypt dPhysics Department, Faculty of Science, Menoufia University, Shebin El-Koom, Menoufia, Egypt eInstitute of Natural Science and Mathematics, Ural Federal University, Ekaterinburg 620002, Russian Federation fIstinye University, Faculty of Engineering and Natural Sciences, Computer Engineering Department, Istanbul, 34396, Turkey gInstitute of Physics and Technology, Ural Federal University, 19 Mira St., 620002, Yekaterinburg, Russia *Corresponding author. Physics Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia. **Corresponding author. Department of Physics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia. *** Corresponding author. Physics Department, Faculty of Science, Al-Azhar University, Assiut, 71452, Egypt. E-mail addresses: [email protected] (M.A.M. Uosif), [email protected] (S.A.M. Issa), [email protected] (H.M.H. Zakaly) The authors would like to apologise for any inconvenience caused. © 2023 Elsevier B.V
An analytical study of the theatre of the Syrian playwright Saadallah Wannous, with particular emphasis on the plays written after the 1967 war
No full textThis study is an examination of the life and work of
the Syrian dramatist Saadallah Wannous (1941-1997). Wannous's name is virtually unknown in the West; only two academic studies of any significance have appeared in English on this eminent and challenging writer, who was honoured by UNESCO at the end of his life. Even in the Arab world his standing rests largely upon his celebrity as a cultural icon, since professional performances of his plays are rare due to the decline of the theatre in the region, and little attention has been devoted to theatre studies by Arab academics. The two studies in English do not attempt to be comprehensive but focus on particular stages of Wannous's career. This study is, therefore, the first to encompass the full range of Wannous's work. To do so it combines an account of his life which seeks to comprehend the various forces that shaped his thinking with an analysis of his dramatic works. The study concentrates on the plays written in the years following the trauma inflicted on the Arab world by the catastrophe of their
defeat in the Arab-Israeli war of June, 1967. Wannous's career can be divided into three phases: the immature plays of his young manhood which are influenced by European models and generally focus on the social condition of the individual; his middle period - the `theatre of politicisation', when his Marxist politics were the main
factor shaping his drama; and his late works, which are characterised by an extraordinary freedom of thought and expression. The introduction places Wannous in his historical and sociocultural context and provides a brief background explaining the literary and theatrical traditions of the Arab world that influenced his activity as a dramatist. Each phase is then examined in turn and the plays are analysed in accordance with the focus of the study. This means that emphasis is given to the middle period,
but no significant work is neglected. The study aims to trace the trajectory of Wannous's development using a
variety of sources: the plays themselves, Wannous's own journalism and critical writings, interviews with his widow, his friends and colleagues, and numerous
journals, books and articles, some of which contain
important interviews with Wannous that shed light on his thought and ways of working. Use is also made of the
two studies mentioned above. The study shows that Wannous's theatre was influenced by the key political, social and cultural developments of his time, and that he
constantly sought to find forms that would express those transformations in dramatic terms
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