198,765 research outputs found
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No full textThe aim of the research is to enhance the mechanical properties of 9%Ni steel LNG tank welded joints and significantly impact toughness. The experiment started by using 10- and 14-mm plates of 9%Ni steel .welding was done using E NiCrFe4 with a diameter of 3.2 mm for two groups of specimens ( 3 specimens of 10 mmm and 3 specimen of 14mm). In the same way, using E NiCrMo3 . the welding is done by using two WPS one for each electrode. all welding is done in a vertical uphill position. measuring the ampere and volt using a clamp ampere. Travel speed is measured by a stopwatch for time and distance by a ruler. All specimens were inspected using LPT and gamma-ray. the mechanical tests were micro Vickers hardness and impact toughness. Plus the macrograph and microstructure by using an optical microscope
シリア・ラッカ県，Tell Ghanem al-Ali 周辺に発達する河成段丘
No full textRiver terraces around Tell Ghanem al-Ali, Raqqa, Syria, were studied to clarify geological and environmental settings of the tell. Five levels of terraces are recognizable on the basis of available topographic maps and field observation: terraces I (250 m a.s.l.), II (242–245 m), III (237–240 m), IV (233–234 m) and V (ca. 230 m) in descending order. Tell Ghanem al-Ali is located on the terrace V (lowermost terrace), which is 1–2 m higher than the flood plain of Euphrates. Sediments around the tell are divided into five units: channel and flood plain deposits of modern Euphrates, sediments of the lowermost terrace and Units 1–3. Stratigraphic relationship among them suggests that Unit 1, Unit 2 and sediment of the lowermost terrace were deposited in the depositional phase of this area, and that terraces I–IV were formed in the erosional phase. Stratigraphy of the Tell Ghanem al-Ali and the lowermost terrace, and available 14C dating data indicate that settlement of the tell began during the formation of the lowermost terrace at ca. 3000 cal y BC
シリア・ラッカ県，Tell Ghanem al-Ali 周辺に発達する河成段丘
No full text2010-12-25River terraces around Tell Ghanem al-Ali, Raqqa, Syria, were studied to clarify geological and environmental settings of the tell. Five levels of terraces are recognizable on the basis of available topographic maps and field observation: terraces I (250 m a.s.l.), II (242–245 m), III (237–240 m), IV (233–234 m) and V (ca. 230 m) in descending order. Tell Ghanem al-Ali is located on the terrace V (lowermost terrace), which is 1–2 m higher than the flood plain of Euphrates. Sediments around the tell are divided into five units: channel and flood plain deposits of modern Euphrates, sediments of the lowermost terrace and Units 1–3. Stratigraphic relationship among them suggests that Unit 1, Unit 2 and sediment of the lowermost terrace were deposited in the depositional phase of this area, and that terraces I–IV were formed in the erosional phase. Stratigraphy of the Tell Ghanem al-Ali and the lowermost terrace, and available 14C dating data indicate that settlement of the tell began during the formation of the lowermost terrace at ca. 3000 cal y BC.departmental bulletin pape
Electrochemical deposition of macroporous platinum, palladium and cobalt films using polystyrene latex sphere templates
No full textHighly ordered macroporous films of platinum, palladium and cobalt with regular arrays of spherical pores with diameters of 0.40, 0.70 or 1 mu m are prepared by electrochemical deposition into the interstitial spaces of a template formed by polystyrene latex spheres self-assembled on gold electrodes; after deposition of platinum, palladium or cobalt, the polystyrene spheres are fully removed by washing in toluene to leave a highly periodic, hexagonal close packed, interconnected network of monodisperse spherical pores within the metal film, the size of which is determined by the diameter of the polystyrene latex particles used to prepare the template
Advances in nad-lowering agents for cancer treatment
No full textNicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and gene expression. Since such processes are fundamental to support cancer cell survival and proliferation, sustained NAD production is a hallmark of many types of neoplasms. Depleting intratumor NAD levels, mainly through interference with the NAD-biosynthetic machinery, has emerged as a promis-ing anti-cancer strategy. NAD can be generated from tryptophan or nicotinic acid. In addition, the “salvage pathway” of NAD production, which uses nicotinamide, a byproduct of NAD degradation, as a substrate, is also widely active in mammalian cells and appears to be highly exploited by a subset of human cancers. In fact, research has mainly focused on inhibiting the key enzyme of the latter NAD production route, nicotinamide phosphoribosyltransferase (NAMPT), leading to the identification of numerous inhibitors, including FK866 and CHS-828. Unfortunately, the clinical activity of these agents proved limited, suggesting that the approaches for targeting NAD production in tumors need to be refined. In this contribution, we highlight the recent advancements in this field, including an overview of the NAD-lowering compounds that have been reported so far and the related in vitro and in vivo studies. We also describe the key NAD-producing pathways and their regulation in cancer cells. Finally, we summarize the approaches that have been explored to optimize the therapeutic response to NAMPT inhibitors in cancer
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