170,457 research outputs found
Endocrine changes and follicular development in patients during ovulation induction using Goserelin and different gonadotropin treatments.
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Endocrine changes and follicular development in patients during ovulation induction using Goserelin and different gonadotropin treatments
No full textMaximum reduction of patient monitoring and fixed programming: a simplified protocol for intrauterine insemination cycles
No full textBeing a rheumatologist and a patient with a rheumatic disease today: A perspective at the time of COVID-19
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Il supporto della fase luteale nei cicli di riproduzione assistita: risultati comparativi
No full textCombined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells
No full textGerli and Moyle and colleagues show that treatment with molecules involved in developmental specification of pericytes (DLL4 and PDGF-BB) alters satellite cell fate and provides them with features potentially relevant for novel cell therapy protocols.</p
Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population-based multicentre cohort study.
No full textCardiovascular disease risk burden in primary Sjögren's syndrome: results of a population-based multicentre cohort study.
Bartoloni E1, Baldini C, Schillaci G, Quartuccio L, Priori R, Carubbi F, Bini V, Alunno A, Bombardieri S, De Vita S, Valesini G, Giacomelli R, Gerli R.
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Abstract
OBJECTIVE:
Systemic autoimmune diseases, in particular systemic lupus erythematosus and rheumatoid arthritis, are characterized by a high risk of premature cardiovascular (CV) events. Disease-related characteristics and traditional CV disease risk factors may contribute to atherosclerotic damage. However, there are limited data on the risk of overt CV events in primary Sjögren's syndrome (pSS).
METHODS:
We retrospectively analysed a cohort of patients with 1343 pSS. Disease-related clinical and laboratory data, traditional CV disease risk factors and overt CV events were recorded. Prevalence of traditional CV disease risk factors and of major CV events was compared between a subgroup of 788 female patients with pSS aged from 35 to 74 years and 4774 age-matched healthy women.
RESULTS:
Hypertension and hypercholesterolaemia were more prevalent, whereas smoking, obesity and diabetes mellitus were less prevalent, in women with pSS than in control subjects. Cerebrovascular events (2.5% vs. 1.4%, P = 0.005) and myocardial infarction (MI) (1.0% vs. 0.4%, P = 0.002) were more common in patients with pSS. In the whole population, central nervous system involvement (odds ratio (OR) 5.6, 95% confidence interval (CI) 1.35-23.7, P = 0.02) and use of immunosuppressive therapy (OR 1.9, 95% CI 1.04-3.70, P = 0.04) were associated with a higher risk of CV events. Patients with leucopenia had a higher risk of angina (P = 0.01).
CONCLUSIONS:
pSS is associated with an increased risk of cerebrovascular events and MI. Disease-related clinical and immunological markers may have a role in promoting CV events.
© 2015 The Association for the Publication of the Journal of Internal Medicine.
KEYWORDS:
Sjögren's syndrome; atherosclerosis; autoimmune disease; cardiovascular disease risk factor
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