923 research outputs found
Visual Abstract - Supplemental material for Preclinical Comparison of Distal Off-Pump Anastomotic Remodeling: Hand-Sewn Versus ELANA Heart Bypass
No full textSupplemental material, sj-pptx-1-inv-10.1177_15569845221079606 for Preclinical Comparison of Distal Off-Pump Anastomotic Remodeling: Hand-Sewn Versus ELANA Heart Bypass by David Stecher, Marieke Hoogewerf, Bart P. van Putte,
Shadan Osman, Pieter A. Doevendans, Cornelis Tulleken, Lex van Herwerden, Gerard Pasterkamp and Marc P. Buijsrogge in Innovations</p
Scientists on the Spot: Re-defining atherosclerosis through biobanks
No full textIn this Onlife interview, Professor Pasterkamp talks about current challenges in the atherosclerotic field and the best ways to translate basic science into clinical practice
Supplemental Material, 20171119_Supl_fig_2 - Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography
No full textSupplemental Material, 20171119_Supl_fig_2 for Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography by Crystel M. Gijsberts, Hester M. den Ruijter, Dominique P. V. de Kleijn, Albert Huisman, Maarten ten Berg, Mark de Groot, Richard H. A. van Wijk, Folkert W. Asselbergs, Michiel Voskuil, Gerard Pasterkamp, Wouter W. van Solinge, and Imo E. Hoefer in Angiology</p
Supplementary_Material - Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography
No full textSupplementary_Material for Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography by Crystel M. Gijsberts, Hester M. den Ruijter, Dominique P. V. de Kleijn, Albert Huisman, Maarten ten Berg, Mark de Groot, Richard H. A. van Wijk, Folkert W. Asselbergs, Michiel Voskuil, Gerard Pasterkamp, Wouter W. van Solinge, and Imo E. Hoefer in Angiology</p
Supplemental Material, 20171119_Supl_fig_3 - Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography
No full textSupplemental Material, 20171119_Supl_fig_3 for Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography by Crystel M. Gijsberts, Hester M. den Ruijter, Dominique P. V. de Kleijn, Albert Huisman, Maarten ten Berg, Mark de Groot, Richard H. A. van Wijk, Folkert W. Asselbergs, Michiel Voskuil, Gerard Pasterkamp, Wouter W. van Solinge, and Imo E. Hoefer in Angiology</p
Supplemental Material, 20171119_Supl_fig_1 - Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography
No full textSupplemental Material, 20171119_Supl_fig_1 for Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography by Crystel M. Gijsberts, Hester M. den Ruijter, Dominique P. V. de Kleijn, Albert Huisman, Maarten ten Berg, Mark de Groot, Richard H. A. van Wijk, Folkert W. Asselbergs, Michiel Voskuil, Gerard Pasterkamp, Wouter W. van Solinge, and Imo E. Hoefer in Angiology</p
PlaqOmics Leducq Fondation Trans-Atlantic Network: Defining the Roles of Smooth Muscle Cells and Other Extracellular Matrix-Producing Cells in Late-Stage Atherosclerotic Plaque Pathogenesis
No full textThromboembolic events secondary to rupture or erosion of advanced atherosclerotic plaques represent the leading cause of death worldwide. However, the mechanisms that regulate plaque stability are poorly understood. Human pathology studies show that lesions containing a high ratio of ACTA2+ (SM alpha-actin) to CD68+ (cluster of differentiation 68) cells and a thicker ECM (extracellular matrix)-rich fibrous cap are more stable, but there are major ambiguities regarding the origins and functions of ACTA2+ cells within lesions, as well as the mechanisms that regulate their investment and retention in the protective fibrous cap. The overall hypothesis of our Leducq Fondation PlaqOmics Transatlantic Network is that detrimental reprogramming of smooth muscle cells (SMCs) and other ACTA2+ fibrous cap cells destabilizes atherosclerotic plaques and that there are critical genetic determinants of coronary artery disease (CAD) risk that act, in part, by impacting phenotypic transitions of fibrous cap cells. Our ultimate goals are to (1) define distinct SMC phenotypes within human lesions and how these change as a function of lesion severity and vulnerability for rupture or erosion and (2) to use complementary human and mouse studies to determine mechanisms by which these cells impact lesion pathogenesis and to identify novel therapeutic targets that promote beneficial (plaque stabilizing) changes in the phenotype of SMC and other ECM-producing lesion cells
Exploring the causal inference of shear stress associated DNA methylation in carotid plaque on cardiovascular risk
No full textBACKGROUND AND AIMS: Atherosclerosis is a lipid-driven inflammatory disease presumably initiated by endothelial activation. Low vascular shear stress is known for its ability to activate endothelial cells. Differential DNA methylation (DNAm) is a relatively unexplored player in atherosclerotic disease development and endothelial dysfunction. Previous studies showed that the expression of 11 genes was associated with differential DNAm due to low shear stress in murine endothelial cells. We hypothesized a causal relationship between DNAm of shear stress associated genes in human carotid plaque and increased risk of cardiovascular disease. METHODS: Using Mendelian randomisation (MR) analysis, we explored the potential causal role of DNAm of shear stress associated genes on cardiovascular disease risk. We used data from the Athero-Expression Biobank Study for the discovery of methylation quantitative trait loci (mQTLs) in 442 advanced carotid plaques. Next, we performed MR analysis using these mQTLs and publicly available GWAS summary statistics of coronary artery disease (CAD) and ischemic stroke (IS). RESULTS: We discovered 9 mQTLs in plaque in the promoters of shear stress associated genes. We found no significant effect of shear stress gene promoter methylation and increased risk of CAD and IS. CONCLUSIONS: Differential methylation of shear stress associated genes in advanced atherosclerotic plaques in unlikely to increase cardiovascular risk in human
StructuralComponents 6: An early-stage design tool for flexible topologies of mid-rise concrete buildings
No full textThis paper discusses the project StructuralComponents 6, a continuation of the ongoing project StructuralComponents which focuses on the development of computational tools for conceptual building design beginning with Breider [1]. The goal of StructuralComponents 6 is to develop a tool for the conceptual design of mid-rise concrete buildings laterally supported by shear walls. The tool allows a user to digitally construct a prismatic, rectangular building design with a custom number and arrangement of shear walls and performs structural validation of any given design in terms of stiffness, strength and stability. The project in split into two main phases. 1) A calculation method is developed that can be applied to a flexible number and arrangement of shear walls, assuming the shear walls are connected by infinitely rigid floors. 2) The tool is implemented using Python and Grasshopper. A case study is performed to determine the applicability of the tool to real-life building design. It is concluded that the rigid-floor calculation method is adequate for the design of buildings with minimal out-of-plane floor effects (i.e. buildings with pre-cast floors) and minimal torsional effects. Through the case study, it is shown that the tool can be successfully applied to a building with a complex arrangement of shear walls.Applied Mechanic
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