6 research outputs found
Solution-phase combinatorial chemistry--the activated core approach ; II. Porphyrin-based small molecule receptors
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.Includes bibliographical references.by Gerald W. Shipps, Jr.Ph.D
ChemInform Abstract: Direct Synthesis of Cbz-Protected (2-Amino)-6-(2-aminoethyl)pyridines.
No full text
Synthesis and screening of small molecule libraries active in binding to DNA
No full textFive synthetic combinatorial libraries of 2,080 components each were screened as mixtures for inhibition of DNA binding to two transcription factors. Rapid, solution-phase synthesis coupled to a gel-shift assay led to the identification of two compounds active at a 5- to 10-μM concentration level. The likely mode of inhibition is intercalation between DNA base pairs. The efficient deconvolution through sublibrary synthesis augurs well for the use of large mixtures of small, nonpeptide molecules in biological screens
'Beyond, both the Old World, and the New': Authority and Knowledge in the works of Francis Bacon, with special reference to the New Atlantis
No full textPhDThis study investigates the role of authority in the works of Francis Bacon,
arguing that the issue of authority provides not only an interpretation of New
Atlantis, but an important structural component of his body of works. From
the first manifestation of his philosophical project to his last works of natural
history, authority is an all-pervasive issue - the authority of nature, of
scripture, of the named author, and how authority functions in the
dissemination of natural knowledge. Chapter one argues that the publication
of New Atlantis alongside Sylva sylvarum in 1626/7 was more the result of
William Rawley's need to assert his own authority as the protector and
disseminator of Bacon's textual legacy than an appreciation of the work's own
qualities. Chapter two considers Bacon's views of history and time,
suggesting that Bacon not only conceived of a new, progressive mode of
historical time which would allow for the assertion of a textual authority based
on the records of a civilisation unbroken by the vicissitudes of time, but that
he figured these theories in New Atlantis. Chapter three argues that Bacon
used theology both as defence and imperative to his intellectual programme,
while his attempt to move beyond the deterministic, Calvinist world-view to
allow for multiple possible futures, or `chance': Bacon could then present
experiment as the way of eliminating chance, in order to accelerate the rate of
new discovery. Chapter four investigates Bacon's manipulations of textual
authority, from the early rehearsals of the Instauratio magna to the
performance of reliability in print in Sylva sylvarum. Finally, the afterword
seeks to suggest that the New Atlantis hinges on the issues of authority with
which Bacon engaged throughout his career and writings: in the issue of
authority, Francis Bacon found the beginning and the end of his philosophy
